NFL Week 1 Odds and Betting Lines: Eagles Big Faves in Season Opener

Toss on a sweater and pump up the pumpkin spice. Football season is here!

NFL Week 1 odds have been hanging around since the 2025 schedule dropped back in the spring, but most people haven’t looked at those spreads and totals until now.

While you were enjoying your summer vacation, bookmakers were adjusting those openers based on early action, injuries, transactions, and preseason prep.
 
Here’s a glance at the Week 1 NFL odds as we close in on kickoff and how far they’ve come since May.

NFL odds Week 1

Matchup	Spread	Moneyline	Over/Under
Cowboys vs Eagles	Eagles -7.5	Cowboys +290 Eagles -360	47.5
Chiefs vs Chargers	Chargers +3	Chiefs -156 Chargers +132	45.5
Cardinals vs Saints	Saints +5.5	Cardinals -270 Saints +220	42.5
Buccaneers vs Falcons	Falcons +2.5	Buccaneers -136 Falcons +116	46.5
Giants vs Commanders	Commanders -6	Giants +225 Commanders -275	45.5
Raiders vs Patriots	Patriots -3.5	Raiders +126 Patriots -148	44.5
Bengals vs Browns	Browns +5.5	Bengals -220 Browns +184	47.5
Steelers vs Jets	Jets +3	Steelers -148 Jets +126	37.5
Panthers vs Jaguars	Jaguars -3	Panthers +132 Jaguars -156	46.5
Dolphins vs Colts	Colts -1.5	Dolphins +104 Colts -122	46.5
Titans vs Broncos	Broncos -7.5	Titans +315 Broncos -400	41.5
49ers vs Seahawks	Seahawks +2.5	49ers -136 Seahawks +116	44.5
Lions vs Packers	Packers -2.5	Lions +122 Packers -144	47.5
Texans vs Rams	Rams -2.5	Texans +120 Rams -142	44.5
Ravens vs Bills	Bills -1.5	Ravens -104 Bills +112	52.5
Vikings vs Bears	Bears +1.5	Vikings -132 Bears +112	43.5

Lines as of 9-1

Cowboys vs Eagles odds (Thursday, 8:20 p.m. ET, NBC)

Opening line

• Eagles -6.5
• Over/Under 47.5
• View full Cowboys vs. Eagles odds and matchup
• Read our Cowboys vs. Eagles picks and predictions (coming soon)

Books had the Eagles as low as 6.5-point home chalk for the season opener. As the Micah Parsons contract situation got sticky, the market moved to a touchdown. When Dallas traded the star pass rusher the week before the season, the line jumped to Philadelphia -7.5.

Also see: full Thursday Night Football odds

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Chiefs vs Chargers odds (Friday, 8:00 p.m. ET, YouTube)

Opening line

• Chargers +3
• Over/Under 45.5
• View full Chiefs vs. Chargers odds and matchup
• Read our Chiefs vs. Chargers picks and predictions (coming soon)

This neutral-site AFC West war opened with Kansas City as a 3-point favorite in Brazil. The spread made a brief stop at KC -3.5, which drew immediate buyback on the Chargers as underdogs. That erased the hook and has the market sitting at a juiced -3 for the Chiefs. 

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Cardinals vs Saints odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Saints +3.5
• Over/Under 43.5
• View full Cardinals vs. Saints odds and matchup
• Read our Cardinals vs. Saints picks and predictions (coming soon)

The opening line was Arizona -3.5 on the road, but when Derek Carr called it quits, the spread jumped to -5.5. That’s taken action on the Cardinals, pushing the line through the key number of six and to as high as -6.5. The total dipped from 43.5 to 42.5 points.

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Buccaneers vs Falcons odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Falcons +2.5
• Over/Under 46.5
• View full Buccaneers vs. Falcons odds and matchup
• Read our Buccaneers vs. Falcons picks and predictions (coming soon)

Tampa Bay opened -2.5 on the road at Atlanta. There have been bites off that spread during the offseason, slipping this line to Bucs -1.5. But as we get closer to kickoff, money likes the road chalk and we’re seeing Tampa Bay back to -2.5. This total has dropped from as high as 48.5 to 46.5 O/U.

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Giants vs Commanders odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Commanders -7.5
• Over/Under 45.5
• View full Giants vs. Commanders odds and matchup
• Read our Giants vs. Commanders picks and predictions (coming soon)

Washington opened as a 7.5-point home favorite over the Giants in Week 1. New York has received some sharper opinions in the offseason, knocking this spread through key numbers all summer. The Giants are down to -6 at most shops with some showing -5.5 as we head into Week 1.

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Raiders vs Patriots odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Patriots -3.5
• Over/Under 43.5
• View full Raiders vs. Patriots odds and matchup
• Read our Raiders vs. Patriots picks and predictions (coming soon)

New England opened as big as -3.5 for this Week 1 date with Las Vegas. Injuries and offseason moves for the Raiders chipped this spread down to -2.5 at most books. The total has been fluctuating, opening at 43.5 and then sliding to 41.5 before rebounding to 44.5. 

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Bengals vs Browns odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Browns +4.5
• Over/Under 44.5
• View full Bengals vs. Browns odds and matchup
• Read our Bengals vs. Browns picks and predictions (coming soon)

Cincinnati’s slow starts had bookies playing it cool with this Week 1 AFC North game, opening the Bengals as 4.5-point faves. Cleveland’s quarterback situation soured early money, sending this spread as high as -6 before settling in at Cincy -5.5 on the road. The total opened at 44.5 points and has jumped a full FG to 47.5 O/U.

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Steelers vs Jets odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Jets +3
• Over/Under 41.5
• View full Steelers vs. Jets odds and matchup
• Read our Steelers vs. Jets picks and predictions (coming soon)

Pittsburgh opened between -2.5 and -3 at most books in the spring, with the intention Aaron Rodgers would be the QB for Week 1. The veteran passer officially signed on in June, knocking this spread to -3.5. However, since then, the line has slowly crept back down and sits short of a field goal at some shops. The total opened at 41.5 and shriveled to as low as 37.5 this offseason.

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Panthers vs Jaguars odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Jaguars -3.5
• Over/Under 45.5
• View full Panthers vs. Jaguars odds and matchup
• Read our Panthers vs. Jaguars picks and predictions (coming soon)

Jacksonville opened as a 3.5-point favorite hosting Carolina in Week 1. That line slid as low as -2.5 before money on the Jaguars brought it back to -3. The total took a ride too, after opening at 45.5 and jumping to 47.5 before the buyback dropped it to 46.5 O/U.

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Dolphins vs Colts odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Colts -1.5
• Over/Under 45.5
• View full Dolphins vs. Colts odds and matchup
• Read our Dolphins vs. Colts picks and predictions (coming soon)

The Colts opened at -1.5 vs. Miami in Week 1, and the decision to start Daniel Jones over Anthony Richardson actually moved the spread to Indy -2.5. That hasn’t lasted, as money on the Dolphins dropped this line back to -1.5 and as short as -1 at some shops heading into game week.

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Titans vs Broncos odds (Sunday, 4:05 p.m. ET, FOX)

Opening line

• Broncos -7.5
• Over/Under 42.5
• View full Titans vs. Broncos odds and matchup
• Read our Titans vs. Broncos picks and predictions (coming soon)

Denver opened as a 7.5-point home favorite to Tennessee, and that spread has been up and down all summer, soaring to -8.5 before buyback down to the original post. Most books are dealing the Broncos as 8-point chalk, giving rookie QB Cam Ward a “Welcome to the Pros” matchup.

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49ers vs Seahawks odds (Sunday, 4:05 p.m. ET, FOX)

Opening line

• Seahawks +1.5
• Over/Under 45.5
• View full 49ers vs. Seahawks odds and matchup
• Read our 49ers vs. Seahawks picks and predictions (coming soon)

San Francisco left a bad taste in the mouths of bettors in 2024 and opened as a 1.5-point favorite at Seattle in Week 1. That’s climbed to -2.5 with more interest in the Niners than the Seahawks and new QB Sam Darnold. This total opened 45.5 and is now 44.5 O/U.

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Lions vs Packers odds (Sunday, 4:25 p.m. ET, CBS)

Opening line

• Packers -1.5
• Over/Under 47.5
• View full Lions vs. Packers odds and matchup
• Read our Lions vs. Packers picks and predictions (coming soon)

The Packers opened as 1.5-point home favorites to the Lions in Week 1, and that spread jumped to -2.5 when Green Bay traded for star pass rusher Micah Parsons a week before the season. The total opened at 47.5 points, climbed as high as 49.5, but has since settled back at 47.5 O/U. 

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Texans vs Rams odds (Sunday, 4:25 p.m. ET, CBS)

Opening line

• Rams -3.5
• Over/Under 45.5
• View full Texans vs. Rams odds and matchup
• Read our Texans vs. Rams picks and predictions (coming soon)

The Rams opened as 3.5-point favorites in this non-conference clash in Week 1. But with Matthew Stafford’s back giving him fits this summer and lots of love for Houston, this spread went through the field goal and is at L.A. -2.5. 

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Ravens vs Bills odds (Sunday, 8:20 p.m. ET, NBC)

Opening line

• Bills -1.5
• Over/Under 52.5
• View full Ravens vs. Bills odds and matchup
• Read our Ravens vs. Bills picks and predictions (coming soon)

Buffalo opened as a 1.5-point favorite for this massive Sunday nighter and has stayed steady for the most part this offseason. The total opened at 51.5 and reached 52.5 before Under money pushed the number down to 50.5 O/U. 

Also see: full Sunday Night Football odds

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Vikings vs Bears odds (Monday, 8:15 p.m. ET, ABC/ESPN)

Opening line

• Bears +1.5
• Over/Under 45.5
• View full Vikings vs. Bears odds and matchup
• Read our Vikings vs. Bears picks and predictions (coming soon)

Minnesota is a 1.5-point road favorite for the first Monday Night Football game of the season. That spread has hung tough all summer while the total has slimmed two points from an opener of 45.5 to 43.5 O/U. 

Also see: full Monday Night Football odds

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