The AFC South Champions head out west to take on the Los Angeles Rams in what should be an exciting matchup.
My Texans vs. Rams predictions expect a low-scoring game between two teams with plenty of question marks.
Find out more in my NFL picks below, with the game kicking off at 4:25 p.m. ET at SoFi Stadium and available to watch on CBS.
Texans vs Rams prediction
Texans vs Rams Best bet: Under 43.5 (-115)
Two big factors come into play when considering this 43.5-point total. For the Los Angeles Rams, things look positive: Davante Adams is in town, Kyren Williams is healthy and signed to a new deal, and Matthew Stafford is fit, but just how healthy is he really?
That’s going to be put to the test as they face a Houston Texans defense that could quite comfortably be the best in the NFL. You have the second-best edge rusher in the league in Will Anderson Jr. on one side of the line, and opposite him is Danielle Hunter, who is also an elite, potentially Top-10 defensive end.
There’s going to be a lot of pressure on Stafford, and even if he really is in great health, then they could still be in big trouble.
Then there’s the Texans. We should see C.J. Stroud rebound after his sophomore slump, but this is still a team that’s had huge changes on the offensive line and might need time to gel.
And without Joe Mixon, the running game now lies in the hands of Nick Chubb, and we don’t know if he’s going to be anywhere near the guy he was pre-injuries.
Texans vs Rams same-game parlay
We’re also going to add the Texans to win. This team has a truly elite defense and should be able to limit the Rams to a couple of scores.
To finish off the SGP, we’re backing Nico Collins to score. Collins is one of the league’s best wideouts and scored eight touchdowns last season, despite missing five games due to injury and subsequently working his way back to full health.
Texans vs Rams 3-leg SGP
- Under 43.5
- Texans moneyline
- Nico Collins anytime touchdown
Our big-ticket SGP: Wideouts shine at SoFi Stadium
- Davante Adams gives the team a real X receiver and is now L.A.'s main receiving threat in the red zone.
- C.J. Stroud averaged 223.9 yards per game last year, but with a new OC and a healthy Collins, as well as Christian Kirk and Jayden Higgins in his WR corps, we should see him improve upon his 2024 performances.
Texans vs Rams 5-leg SGP
- Under 43.5
- Texans moneyline
- Nico Collins anytime touchdown
- Davante Adams anytime touchdown
- C.J. Stroud Over 233.5 passing yards
Texans vs Rams game predictions
Texans vs Rams moneyline prediction
Houston's defensive front is truly elite, and with doubts over Matthew Stafford's health, it should be concerning that he'll be under huge pressure every snap.
Texans vs Rams spread prediction
The Rams failed to cover the spread in all three games as home favorites last year and might struggle against this Texans defense.
Texans vs Rams Over/Under prediction
If this Texans defense does as expected, it’ll keep the score down, just as Houston might struggle to put up big numbers with the state of its running game.
Texans vs Rams odds
- Spread: Texans +2.5 | Rams -2.5
- Moneyline: Texans +120 | Rams -140
- Over/Under: Over 44.5 | Under 44.5
More NFL picks and odds from Covers
Texans vs Rams trend to know
The Texans have cashed the Under in 15 of their last 22 games. Find more NFL betting trends for Texans vs. Rams.
How to watch Texans vs Rams
| Location | SoFi Stadium, Los Angeles, CA |
| Date | Sunday, September 7, 2025 |
| Kickoff | 4:25 p.m. ET |
| TV | CBS |
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