NFL Picks Against the Spread for Every Week 8 Game

Chris Vasile breaks down his favorite NFL picks against the spread for Week 8, including the Los Angeles Chargers and Buffalo Bills.

Chris Vasile - Betting Analyst at Covers.com
Chris Vasile • Betting Analyst
Oct 21, 2025 • 14:50 ET • 4 min read
Los Angeles Chargers quarterback Justin Herbert (10) throws the ball.
Photo By - Imagn Images. Los Angeles Chargers quarterback Justin Herbert (10) throws the ball.

Week 7 of the NFL season belonged to the favorites as they dominated both straight up and against the spread. 

This week, I'm looking to bounce back with my selections after going 6-9 overall. 

Here are my best Week 8 NFL picks against the spread, headlined by the Los Angeles Chargers. 

Week 8 NFL picks against the spread

Matchup Pick
Vikings Vikings vs Chargers Chargers Chargers (-3)
Jets Jets vs Bengals Bengals Bengals (-6.5)
Bears Bears vs Ravens Ravens Bears (+6.5)
Dolphins Dolphins vs Falcons Falcons Falcons(-7.5)
Browns Browns vs Patriots Patriots  Patriots (-7)
Giants Giants vs Eagles Eagles Giants (+7)
Bills Bills vs Panthers Panthers Bills (-7.5)
49ers 49ers vs Texans Texans Texans (-1.5)
Buccaneers Buccaneers vs Saints Saints Saints (+4.5)
Cowboys Cowboys vs Broncos Broncos Cowboys (+3.5)
Titans Titans vs Colts Colts Titans (+14.5)
 Packers Packers vs Steelers Steelers Packers (-3.5)
Commanders Commanders vs Chiefs Chiefs Chiefs (-10.5)

Lines courtesy of FanDuel as of 10-21.

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Expert Week 8 NFL ATS picks

Vikings vs. Chargers: Chargers -3

Whether it's J.J. McCarthy or Carson Wentz, there's not a lot to like about this Minnesota Vikings offense right now. I know the Los Angeles Chargers just gave up 38, but they can score points, and I don't see Minnesota keeping pace. 

Jets vs. Bengals: Bengals (-6.5)

I want no part of the New York Jets

Bears vs. Ravens: Bears (+6.5)

Lamar Jackson did not practice with the Baltimore Ravens early in the week, so one can assume he's out. If he is, this is too many points. The Ravens are checked out and at 1-5 would need a miracle to make the playoffs. I'll take the Chicago Bears, who are 4-2 and in the thick of the NFC North title race, to keep this one close.

Dolphins vs. Falcons: Falcons (-7.5)

See Jets vs. Bengals: I want no part of the Miami Dolphins. The Atlanta Falcons return home and, on a fast track, should run away with this game from start to finish. 

Browns vs. Patriots: Patriots (-7)

The New England Patriots have reeled off four straight wins and are in first place in the AFC East. I think it's time we start to take them seriously. They have a Top-5 scoring defense and a Top-10 scoring offense. The Cleveland Browns are 30th across the board in yards, passing yards, and points.

Giants vs. Eagles: Giants (+7)

The Philadelphia Eagles offense broke out in a big way last week, putting up 28 points with DeVonta Smith and AJ Brown doing the heavy lifting. The New York Giants' pass rush should win out and limit the Eagles' passing attack. I'll grab the points here in this divisional matchup. 

Bills vs. Panthers: Bills (-7.5)

The Buffalo Bills are coming off a bye, and everything I've read so far is that they are pissed off with how the last two weeks have gone. I expect a dominant performance vs. a weak Carolina Panthers side. 

49ers vs. Texans: Texans (-1.5)

The San Francisco 49ers are 5-2 and in first place in the NFC West. The Houston Texans are 2-4 and behind the eight ball in the AFC. Yet, they are favorites in this game. I'll play the spread here and take the favorite on home field. 

Buccaneers vs. Saints: Saints (+4.5)

The Tampa Bay Buccaneers are once again battling the injury bug and have some reflecting to do after getting dominated by the Lions. Maybe they aren't as good as people made them out to be? The New Orleans Saints are frisky, and at home, so I'll back them to keep this one close. 


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Cowboys vs. Broncos: Cowboys (+3.5)

The Denver Broncos pulled off a miracle last week, scoring 33 points in the fourth quarter to stun the Giants. That's not happening again. The Dallas Cowboys can score, and the defense looked somewhat respectable last week. I'll play the number here at over a field goal. 

Titans vs. Colts: Titans (+14.5)

Sooner or later, the Indianapolis Colts have to have a slip-up, right? Why not fade them this week, laying more than two touchdowns vs. a Tennessee Titans side that has to find some semblance of pride to play for. 

Packers vs. Steelers: Packers (-3.5)

The Pittsburgh Steelers are frauds, and I believe the Green Bay Packers could very well drop 30. The Packers defense is also miles better, so I'll gladly lay the points with the Cheeseheads. 

Commanders vs. Chiefs: Chiefs (-10.5)

We won't know about Jayden Daniels' status until later in the week, but even if he suits up, a hobbled Washington Commanders QB is no match for the Kansas City Chiefs on the road. He's without his top two receivers, and the offensive line has problems. The Chiefs will dominate on defense, and the offense will continue to rack up the points in an easy win and cover. 

My NFL ATS record is 55-53 this season for -3 units.

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Chris Vasile Covers.com
Betting Analyst

Chris Vasile has been in the betting industry for well over a decade, honing his craft as a writer, editor, and handicapper. Chris has contributed betting and non-betting content for online publications such as ProSportsDaily and The Hockey Writers, in addition to Covers. With a keen interest in soccer, Chris has been featured on Covers' 'Before You Bet', BetMGM Network, and SportsGrid. He also runs his own YouTube channel — Game Day Wagers.

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