As much as college football often proves “any given Saturday” can yield any given result, the Wisconsin Badgers upsetting the Indiana Hoosiers this weekend is a bit beyond fathoming.
Instead, my Wisconsin vs. Indiana predictions expect the Hoosiers to rub in the pain, though for no personal reason aimed at the Badgers.
Kickoff comes at 12 p.m. ET on Saturday, November 15, so let's get right to our college football picks.
Want to make sure Covers shows up often in your Google search results and Discover feed?
Simply click here and add Covers as one of your "source preferences".
Wisconsin vs Indiana prediction
Wisconsin vs Indiana best bet: Fernando Mendoza Over 237.5 passing yards (-114)
Indiana Hoosiers quarterback Fernando Mendoza has cleared this prop just once in his last six games, largely the result of the Hoosiers winning so decisively.
But the time has come to run up the score.
The Heisman race likely will come down to the Big Ten Championship Game, with the winner between Mendoza and Ohio State quarterback Julian Sayin likely also winning that conference title. But it would serve both Indiana and Mendoza well to tighten that race beforehand, given some narratives already arguing in favor of Sayin no matter the result.
Wisconsin will allow for Indiana and Mendoza to post some gaudy stats. The Badgers not only have the No. 112 success rate against the pass, per CFB-graphs.com, but they are also thrown against at the third-highest relative rate in the country.
More simply, opponents not only know Wisconsin is bad against the pass, but they attack it as often as possible.
In fact, just a few weeks ago, Sayin threw 42 times in a 34-0 win at Wisconsin, completing 36 of those passes for 393 yards and four touchdowns. This is a defense begging a Heisman-caliber quarterback to put up a Heisman-worthy stat line.
Wisconsin vs Indiana same-game parlay
Mendoza rushing for a touchdown in three straight games is less a product of his Heisman campaign and more simply a reflection of how thoroughly Indiana can dominate its opponents. Then again, it can be both.
As much as the Hoosiers struggled at Penn State last week, they have gone 3-1 against the spread as four-score favorites this season.
Wisconsin vs Indiana SGP
- Fernando Mendoza Over 237.5 passing yards
- Fernando Mendoza anytime touchdown
- Indiana -29.5
Our deep-ball SGP: Our favorite Indy act
Indiana is primarily a national title contender because of its defense. The Hoosiers had a top-tier offense a year ago but lacked a defense to pair with it. This year’s rendition may be a Top-3 defense in the country, and it should outright shut down a Bottom 20 offense.
Adding an Elijah Sarrat touchdown is largely a nod to the best Indiana receiver missing last week’s action.
Wisconsin vs Indiana SGP
- Fernando Mendoza Over 237.5 passing yards
- Fernando Mendoza anytime touchdown
- Indiana -29.5
- Wisconsin team total Under 6.5
- Elijah Sarrat anytime touchdown
Wisconsin vs Indiana odds
- Spread: Wisconsin +29.5 | Indiana -29.5
- Moneyline: Wisconsin +2500 | Indiana -10000
- Over/Under: Over 43.5 | Under 43.5
Wisconsin vs Indiana trend to know
Wisconsin has cashed five Unders in its six Big Ten games this season, the exception being a mere push against Iowa, when the Hawkeyes won 37-0 in a game with a total of 37. Find more college football betting trends for Wisconsin vs Indiana.
How to watch Wisconsin vs Indiana
| Location | Memorial Stadium, Bloomington, IN |
| Date | Saturday, November 15, 2025 |
| Kickoff | 12:00 p.m. ET |
| TV | BTN |
Wisconsin vs Indiana latest injuries
Wisconsin vs Indiana weather
Monitor gametime conditions with our College football weather info.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
