NFL Week 6 odds kick off in Denver as the Broncos host the Seattle Seahawks on Thursday Night Football, followed by a blockbuster Sunday Night Football clash between the Cowboys and Packers.
The week wraps up in Santa Clara, where the 49ers take on the Washington Commanders on Monday Night Football.
We’re tracking the latest NFL odds, spreads, moneylines, and game totals across the entire Week 6 slate as another action-packed week brings down the curtain.
NFL odds Week 6
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 Seahawksvs  Broncos |
-1.5 42% +1.5 58% |
56% 46% |
o42.5 52% u42.5 54% |
 Texansvs  Jaguars |
+2.5 25% -2.5 75% |
40% 62% |
o42.5 53% u42.5 53% |
 Bearsvs  Falcons |
-1.5 52% +1.5 48% |
55% 47% |
o47.5 53% u47.5 53% |
 Ravensvs  Browns |
-2.5 57% +2.5 43% |
57% 45% |
o40.5 53% u40.5 53% |
 Titansvs  Colts |
+6.5 26% -6.5 74% |
27% 75% |
o43.5 53% u43.5 56% |
 Jetsvs  Patriots |
+6.5 60% -6.5 40% |
27% 75% |
o43.5 52% u43.5 55% |
 Saintsvs  Giants |
-1.5 47% +1.5 53% |
53% 49% |
o44.5 55% u44.5 52% |
 Panthersvs  Eagles |
+2.5 55% -2.5 45% |
50% 56% |
o42.5 53% u42.5 53% |
 Steelersvs  Buccaneers |
-2.5 54% +2.5 46% |
59% 45% |
o38.5 53% u38.5 57% |
 Cardinalsvs  Rams |
+10.5 63% -10.5 37% |
16% 87% |
o50.5 53% u50.5 53% |
 Chargersvs  Chiefs |
+7.5 22% -7.5 78% |
23% 83% |
o45.5 53% u45.5 53% |
 Billsvs  Raiders |
-4.5 55% +4.5 45% |
69% 34% |
o51.5 53% u51.5 53% |
 Cowboysvs  Packers |
-2.5 61% +2.5 39% |
57% 45% |
o50.5 55% u50.5 52% |
 Commandersvs  49ers |
+7.5 17% -7.5 83% |
20% 80% |
o49.5 44% u49.5 56% |
Lines as of 10-7.
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Thursday Night Football: Seahawks vs Broncos odds (8:15 p.m. ET, Prime)
Opening line
- Seahawks -1.5
- Over/Under 42.5
- View full Seahawks vs. Broncos odds and matchup
- Read our Seahawks vs. Broncos picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Thursday Night Football odds
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Sunday Night Football: Cowboys vs Packers odds (8:20 P.M. ET, NBC)
Opening line
- Cowboys -2.5
- Over/Under 50.5
- View full Cowboys vs. Packers odds and matchup
- Read our Cowboys vs. Packers picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Sunday Night Football odds
Monday Night Football: Commanders vs 49ers odds (8:15 p.m. ET, ESPN)
Opening line
- 49ers -7.5
- Over/Under 49.5
- View full Commanders vs. 49ers odds and matchup
- Read our Commanders vs. 49ers picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Monday Night Football odds
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Best NFL bets this week
Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!
Odds are correct at the time of publishing and are subject to change.
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