USC vs Nebraska Prediction, Picks & Odds for November 1 — College Football Week 10

Our college football betting picks see Trojans RB King Miller having a huge day on the ground vs. the Cornhuskers.

Jason Ence - Contributor at Covers.com
Jason Ence • Betting Analyst
Nov 1, 2025 • 09:09 ET • 4 min read

NCAAF

Match starts: 6 hrs
NEB
48 %
USC
52 %
Read Analysis
USC King Miller NCAAF
Photo By - Imagn Images. USC running back King Miller (30) with the ball.

Get ready for a "blackout" at Memorial Stadium as the Nebraska Cornhuskers welcome the USC Trojans on Saturday night.

The Trojans still have a shot at reaching the Big 10 title game, but need to find a way to get a win on the road. The Huskers know Matt Rhule won’t be taking that Penn State job after his extension this week, and the absence of that distraction might spur them to an upset win.

I explain why King Miller will have a big game in my USC vs. Nebraska predictions and college football picks for Saturday, November 1. 

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USC vs Nebraska prediction

USC vs Nebraska best bet: King Miller Over 94.5 rushing yards (-114)

The Michigan Wolverines rank 32nd in success rate against the run, and 45th in EPA/rush this season. And Notre Dame ranks 41st and 35th, respectively, in those two metrics.

King Miller had successful outings against both of those defenses. 

The USC Trojans running back has done well in the absence of Waymond Jordan and Eli Sanders, the two leading backs for the team over the first half of the season. But with both injured, he carried the ball 18 times against both the Wolverines and Fighting Irish. 

If he gets that volume against the Nebraska Cornhuskers, he’s going to have a field day. He ran for 158 against Michigan and 70 in the loss to Notre Dame, and the Cornhuskers have nowhere near the success against the run those two programs have.

The Cornhuskers have already allowed 24 runs of 10+ yards in their five Big 10 games. And no team in the conference has allowed more jaunts of 40+ yards on the ground (four). 

Nebraska ranks 108th in rushing success and 105th in EPA/rush. And given how well the defense has done against the pass this season, it makes sense for Lincoln Riley to utilize Miller early and often to open things up for Jayden Maiava.

Northwestern, Minnesota, and Michigan each had backs go for between 124 and 149 rushing yards. The Cornhuskers won’t be able to load the box due to Maiava’s arm, and that will allow Miller to become the fourth conference opponent to hit the century mark on the ground this season against them.  

USC vs Nebraska same-game parlay

The success on the ground, combined with the cold temps in Lincoln on Saturday night, should play a role in Maiava having a quieter night than usual. This Nebraska secondary will be the best he has faced this season, ranked Top 20 in passing success and 23rd in EPA/pass. 

It will be a "blackout" in Lincoln, with the Cornhuskers rocking the all-black unis. The atmosphere should be electric, and I expect both teams to come out running the ball early with how each struggles at times to defend it. That will lend itself to a very competitive first quarter, with Nebraska tied or leading after 15 minutes. 

USC vs Nebraska 3-leg SGP

  • King Miller Over 94.5 rushing yards
  • Jayden Maiava Under 266.5 passing yards
  • Nebraska +1.5 1Q

Our deep-ball SGP: USC wins low-scoring bout

USC has often underperformed on the road under Riley, but Matt Rhule also can’t seem to win the big one at Nebraska. The Trojans rank 10th defensively in points allowed per quality drive, and the Huskers have had issues finishing drives. 

USC vs Nebraska 5-leg SGP

  • King Miller Over 94.5 rushing yards
  • Jayden Maiava Under 266.5 passing yards
  • Nebraska +1.5 1Q
  • Under 58.5
  • USC moneyline

USC vs Nebraska odds

  • Spread: USC -4.5 | Nebraska +4.5
  • Moneyline: USC -196 | Nebraska +164
  • Over/Under: Over 58.5 | Under 58.5

USC vs Nebraska trend to know

USC has hit the 1H Under in six straight away games (+6.00 Units / 90% ROI). Find more college football betting trends for USC vs Nebraska.

How to watch USC vs Nebraska

Location Memorial Stadium, Lincoln, NE
Date Saturday, November 1, 2025
Kickoff 7:30 p.m. ET
TV NBC

USC vs Nebraska latest injuries

USC vs Nebraska weather

Monitor gametime conditions with our College football weather info.

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Jason Ence - Covers
Betting Analyst

Jason has been hooked on football since watching Real Madrid and Manchester United in the 2003 Champions League, and has been betting on the sport for nearly 15 years. He has given soccer gambling and fantasy advice for nearly a decade, writing for sites including Rotowire, SB Nation, and The TwinSpires Edge.

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