Iowa vs Rutgers Prediction, Picks & Odds for September 19 — College Football Week 4

Caley's prediction: Iowa's defense makes a statement against undefeated Rutgers.

Andrew Caley - Senior Betting Analyst at Covers.com
Andrew Caley • Senior Betting Analyst
Sep 18, 2025 • 11:06 ET • 4 min read

NCAAF

Match starts: 26 hrs
RUTG
48 %
IOWA
52 %
Read Analysis
Mark Gronowski Iowa Hawkeyes NCAAF
Photo By - Imagn Images. Iowa Hawkeyes quarterback Mark Gronowski (11) looks to pass the ball.

The Rutgers Scarlett Knights have made a habit of getting their seasons off to good starts under Greg Schiano. Then Big Ten play starts, and things get a little harder, and the losses pile up.

The Knights will try to buck that trend when they open conference play against the Iowa Hawkeyes under the lights on Friday night.

Unfortunately for football fans in New Jersey, my Iowa vs. Rutgers predictions like the Hawkeyes to do what they do best in this matchup.

Check out my college football picks for this Big Ten throwdown on Friday, Sept. 19.

Iowa vs Rutgers prediction

Iowa vs Rutgers best bet: Iowa -2.5 (-118)

This is a really captivating matchup to kick off Big Ten play on Friday night.

Rutgers begins the season 3-0 for the third-straight year, but has finished each of the past two years 7-6. Which means the Scarlet Knights have played pretty soft non-con schedules. This year was similar, with the only tough matchup coming against the Ohio Bobcats from the MAC.

The Scarlet Knights won that game 34-31as 15.5-point favorites, but the Bobcats scampered for over 200 yards, including giving up 93 to QB Parker Navarro, and the Hawkeyes need to get their own QB going.

It’s been more of what we’ve come to expect from Iowa this season. An excellent defense that gets no support from an underwhelming offense.

That was supposed to change with transfer QB Mark Gronowski. The former South Dakota State Jackrabbits star, who won two national championships at the FCS level, has looked a little overwhelmed in his first three games with an FBS team, throwing for just 306 yards and averaging 2.7 yards per carry.

This is a guy who averaged 8.7 yards per attempt and rushed for over 1,700 yards over four seasons with the Jackrabbits. I expect the Hawkeyes to really try and get Gronowski going in this one, particularly on the ground.

But the strength of this Hawkeyes team will once again be its defense. The Hawkeyes rank 30th in defensive success rate and are fourth in opponent yards per play. 

Rutgers has been hucking it on offense, but it has yet to face a defense at the level of Iowa. At less than a field goal, I’ll back that defense to be the difference here.

Iowa vs Rutgers same-game parlay

Iowa has never really been known for its offensive output with Kirk Ferentz as the head coach, but I think they have an opportunity to at the very least be effective with Gronoswki. Particularly, if he can start running the ball against a Rutgers defense that has given up 5.6 yards per carry this season.

Gronowksi is a guy who rushed for at least 380 yards in each of his four seasons at South Dakota State, averaging 4.7 yards per carry in the process. And if Gronowski can get going on the ground, it will open up the passing game, and in turn help the Hawkeyes cover the 2.5-point chalk.

And even despite his struggles, he's still gone Over this number twice in three games this season.

Now, we do have to note Rutgers’ passing attack. QB Athan Kaliakmanis has been impressive and has spread the ball around to his receivers well. If the Scarlet Knights find the end zone through the air, I like KJ Duff to be on the receiving end.

Duff is a big-bodied receiver sitting at 6-foot-6 and could use his size to his advantage in the redzone against Iowa. Duff has 17 catches on 23 targets for 244 yards and two touchdowns. 

Iowa vs Rutgers SGP

  • Iowa -2.5
  • Mark Gronowski Over 26.5 rushing yards
  • KJ Duff touchdown

Our deep-ball SGP: Gronowski Having His Way

Iowa finally started to open things up with Gronowski last week. He went 16-for-24 for 173 yards.

Rutgers ranks 113th in defensive success rate on dropbacks.

Iowa vs Rutgers SGP

  • Iowa -2.5
  • Mark Gronowski Over 26.5 rushing yards
  • Mark Gronowski Over 127.5 passing yards
  • KJ Duff touchdown

Iowa vs Rutgers odds

  • Spread: Iowa -2.5 | Rutgers +2.5
  • Moneyline: Iowa -146 | Rutgers +122
  • Over/Under: Over 46.5 | Under 46.5

Iowa vs Rutgers trend to know

Iowa has hit the 1Q Under in 7 of their last 11 games for +3.65 Units and a 27% ROI. Find more college football betting trends for Iowa vs Rutgers.

How to watch Iowa vs Rutgers

Location SHI Stadium, Piscataway, NJ
Date Friday, September 19, 2025
Kickoff 8:00 p.m. ET
TV FOX

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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Andrew Caley
Senior Betting Analyst

When his dreams of becoming the next Steve Nash died, all Andrew "Taco" Caley wanted to do was write about sports, something he's been doing at Covers for more than a decade. A Journalism School grad from Holland College in Charlottetown, PEI, Andrew previously worked at The Chronicle Herald and Star Metro, but knew in his heart that his future lay in sports. He began at Covers as a news editor and has now done everything under the sun when it comes to content. His work has been seen on TSN, Sportsnet, VSiN, and CBS. These days Andrew's betting expertise is focused on his favorite teams; the Toronto Blue Jays and Toronto Raptors. He's also an avid college football fan and bettor. He can't be friends with you if you don't appreciate a Service Academy Under. The sportsbook where he does the bulk of his betting is bet365 thanks to its numerous prop betting options and competitive odds. His best advice? Find the balance between the numbers and what you see on the playing field. Then find the best price using multiple books. And don’t ask him where the nickname Taco comes from. It's not an interesting story. Seriously.

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