We have a tremendous SEC matchup on tap for Saturday when the 4-1 Alabama Crimson Tide visits the undefeated Missouri Tigers.
While the Tigers boast one of the best defenses in the land, my Alabama vs. Missouri predictions expect Alabama to win this game by a comfortable margin.
Read on for my college football picks for Saturday, October 11.
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Alabama vs Missouri prediction
Alabama vs Missouri best bet: Alabama -3.5 (-104 at FanDuel)
Week 7’s SEC showdown between the No. 8 Alabama Crimson Tide and No. 14 Missouri Tigers features two excellent teams, but the difference lies in who they’ve faced.
Missouri’s undefeated record is impressive, yet its schedule has been far lighter than Alabama’s, which includes back-to-back wins over ranked SEC opponents, highlighted by a road victory at Georgia.
That battle-tested SEC experience gives the Crimson Tide a crucial edge in Saturday’s high-pressure road environment. Missouri’s offense, led by Ahmad Hardy, the nation’s rushing leader, will challenge an Alabama defense allowing over 150 rushing yards per game.
Kalen DeBoer’s group has tightened things up when they needed to, and Alabama possesses the physicality necessary to contain Hardy and disrupt the Tigers’ offensive rhythm. Quarterback Ty Simpson’s efficient passing attack provides balance and big-play capabilities that Missouri hasn’t faced yet.
Expect Missouri to compete, but Alabama’s experience and depth should carry them to a solid cover on Saturday.
Alabama vs Missouri same-game parlay
Alabama wideout Germie Bernard has scored at least one touchdown in four straight games.
Bernard's scoring will help send this game Over the total for the fourth time in six previous meetings.
Alabama vs Missouri SGP
- Alabama -3.5
- Germie Bernard anytime touchdown
- Over 52.5
Our deep-ball SGP: Bama’s Firepower Overwhelms Mizzou
Simpson has thrown two or more passing touchdowns in five straight games.
Hardy has scored at least one touchdown in five straight games.
Alabama vs Missouri SGP
- Alabama -3.5
- Germie Bernard anytime touchdown
- Over 52.5
- Ty Simpson Over 1.5 touchdown passes
- Ahmad Hardy anytime touchdown
Alabama vs Missouri odds
- Spread: Alabama -4 (-110) | Missouri +4 (-110)
- Moneyline: Alabama -180 | Missouri +150
- Over/Under: Over 53.5 (-110) | Under 53.5 (-110)
Alabama vs Missouri trend to know
Missouri has hit the Game Total Over in six of their last nine games at home (+2.70 Units / 27% ROI). Find more college football betting trends for Alabama vs Missouri.
How to watch Alabama vs Missouri
| Location | Memorial Stadium Stadium, Columbia, OH |
| Date | Saturday, October 11, 2025 |
| Kickoff | 12:00 p.m. ET |
| TV | ABC |
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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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