We’ve got a marquee SEC showdown coming up Saturday as the 4-1 Alabama Crimson Tide head to face the undefeated Missouri Tigers.
Missouri’s defense ranks among the nation’s best, but my Alabama vs. Missouri predictions have the Crimson Tide pulling away for a convincing win.
Read on for my college football picks for Saturday, October 11.
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Alabama vs Missouri prediction
Alabama vs Missouri best bet: Alabama -3.5 (-104 at FanDuel)
Week 7’s SEC showdown between the No. 8 Alabama Crimson Tide and No. 14 Missouri Tigers features two excellent teams, but the difference lies in who they’ve faced.
Missouri’s undefeated record is impressive, yet its schedule has been far lighter than Alabama’s, which includes back-to-back wins over ranked SEC opponents, highlighted by a road victory at Georgia.
That battle-tested SEC experience gives the Crimson Tide a crucial edge in Saturday’s high-pressure road environment. Missouri’s offense, led by Ahmad Hardy, the nation’s rushing leader, will challenge an Alabama defense allowing over 150 rushing yards per game.
Kalen DeBoer’s group has tightened things up when they needed to, and Alabama possesses the physicality necessary to contain Hardy and disrupt the Tigers’ offensive rhythm. Quarterback Ty Simpson’s efficient passing attack provides balance and big-play capabilities that Missouri hasn’t faced yet.
Expect Missouri to compete, but Alabama’s experience and depth should carry them to a solid cover on Saturday.
Alabama vs Missouri same-game parlay
Alabama wideout Germie Bernard has scored at least one touchdown in four straight games.
Bernard's scoring will help send this game Over the total for the fourth time in six previous meetings.
Alabama vs Missouri SGP
- Alabama -3.5
- Germie Bernard anytime touchdown
- Over 52.5
Our deep-ball SGP: Bama’s Firepower Overwhelms Mizzou
Simpson has thrown two or more passing touchdowns in five straight games.
Hardy has scored at least one touchdown in five straight games.
Alabama vs Missouri SGP
- Alabama -3.5
- Germie Bernard anytime touchdown
- Over 52.5
- Ty Simpson Over 1.5 touchdown passes
- Ahmad Hardy anytime touchdown
Alabama vs Missouri game predictions
Alabama vs Missouri moneyline prediction
Alabama is coming off consecutive SEC wins over quality opponents. It's that strength of schedule that will help them overcome what appears to be a strong Missouri group.
Alabama vs Missouri spread prediction
I like Alabama to cover the spread for the same reason I expect them to win. Their road win over Georgia demonstrates a battle-tested resilience that Missouri might not possess.
Alabama vs Missouri Over/Under prediction
With two offenses firing on all cylinders, I expect Saturday’s SEC matchup to end Over the total for the fourth time in six meetings.
Alabama vs Missouri odds
- Spread: Alabama -4 (-110) | Missouri +4 (-110)
- Moneyline: Alabama -180 | Missouri +150
- Over/Under: Over 53.5 (-110) | Under 53.5 (-110)
Alabama vs Missouri trend to know
Missouri has hit the Game Total Over in six of their last nine games at home (+2.70 Units / 27% ROI). Find more college football betting trends for Alabama vs Missouri.
How to watch Alabama vs Missouri
| Location | Memorial Stadium Stadium, Columbia, OH |
| Date | Saturday, October 11, 2025 |
| Kickoff | 12:00 p.m. ET |
| TV | ABC |
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Odds are correct at the time of publishing and are subject to change.
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