College Football Picks Against the Spread for Week 11

Our Week 11 college football picks against the spread expect big wins from Texas Tech, Notre Dame, Ohio State, and more.

Chris Gregory - Betting Analyst at Covers.com
Chris Gregory • Betting Analyst
Nov 4, 2025 • 13:24 ET • 4 min read
Jacob Rodriguez Texas Tech Red Raiders Big 12 college football
Photo By - Imagn Images. Texas Tech linebacker Jacob Rodriguez walks off the field.

It's a quiet week in the way of big-time ranked matchups, but with teams jockeying for CFP positioning, every game matters for the programs with real aspirations.

That includes Alabama, which plays host to a Brian Kelly-less LSU squad looking to play spoiler. I pick a side for that game and more in my Week 11 ATS college football picks below.

College football picks against the spread for Week 11

Matchup Pick
Indiana Indiana vs Penn State Penn State Indiana (-14.5)
BYU BYU vs Texas Tech Texas Tech Texas Tech (-10.5)
Georgia Georgia vs Mississippi State Mississippi State Mississippi State (+8.5)
Ohio State Ohio State vs Purdue Purdue Ohio State (-29.5)
Texas A&M Texas A&M vs Missouri Missouri Missouri (+7.5)
Oregon Oregon vs Iowa Iowa Iowa (+6.5)
LSU LSU vs Alabama Alabama LSU (+9.5)
Navy Navy vs Notre Dame Notre Dame Notre Dame (-26.5)

Lines courtesy of FanDuel as of 11-4.

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Expert Week 11 CFB ATS picks

Indiana (-14.5) vs Penn State: Indiana Indiana -14.5

I'm not sure what Penn State has left in the tank after throwing its biggest punch against Ohio State and still coming up way short. The Indiana train rolls on.

BYU vs Texas Tech (-10.5): Texas Tech Texas Tech -10.5

BYU has been playing with fire far too often, falling behind in games and needing heroics to stay undefeated to this point. That simply won't work against Texas Tech.

Georgia (-8.5) vs Mississippi State: Mississippi State Mississippi State +8.5

For as tested as Georgia may be, the Bulldogs haven't shown they can dominate teams away from home. And whatever you may think of Texas, Mississippi State had the Longhorns down 17 late in the game before that collapsing late. 

Ohio State (-29.5) vs Purdue: Ohio State Ohio State -29.5

Only two teams have reached 10 points against this Ohio State defense, a stat that's helped the Buckeyes cover in seven of eight games to start the season. I don't imagine Purdue being a third.

Texas A&M (-7.5) vs Missouri: Missouri Missouri +7.5

While Texas A&M is a deserving touchdown favorite, Mizzou's only home loss came to Alabama by three points. This is not a surefire win for the Aggies.

Oregon (-6.5) vs Iowa: Iowa Iowa +6.5

For every dominant Oregon performance, there's a confounding one (such as being up 7-0 at halftime against 2-6 Wisconsin). Iowa is quietly 6-2, and this is not an easy place to play; just ask Indiana. 

LSU vs Alabama (-9.5): LSU LSU +9.5

This line has widened because of the losses ultimately culminating in Brian Kelly's firing, but with the pressure off, this could be the spot to let loose and make Alabama earn it at home. Let's not forget: the Tide looked incredibly beatable against South Carolina two weekends ago.

Navy vs Notre Dame (-26.5): Notre Dame Notre Dame -26.5

Navy's defense has given up 30+ points in four straight games to North Texas, FAU, Temple, and Air Force. What might we think Notre Dame will do in this game?


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Chris Gregory Covers.com
Betting Analyst

In his four years on the Covers editorial team, Chris Gregory has helped bolster the site’s golf and college football coverage. He brings a journalism and marketing background to his work as a Publishing Editor and can be found across our site covering the Masters, college football futures, and more.

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