It's a quiet week in the way of big-time ranked matchups, but with teams jockeying for CFP positioning, every game matters for the programs with real aspirations.
That includes Alabama, which plays host to a Brian Kelly-less LSU squad looking to play spoiler. I pick a side for that game and more in my Week 11 ATS college football picks below.
College football picks against the spread for Week 11
| Matchup | Pick |
|---|---|
 Indiana vs  Penn State |
(-14.5) |
 BYU vs  Texas Tech |
(-10.5) |
 Georgia vs  Mississippi State |
(+8.5) |
 Ohio State vs  Purdue |
(-29.5) |
 Texas A&M vs  Missouri |
(+7.5) |
 Oregon vs  Iowa |
(+6.5) |
 LSU vs  Alabama |
(+9.5) |
 Navy vs  Notre Dame |
(-26.5) |
Lines courtesy of FanDuel.
Expert Week 11 CFB ATS picks
Indiana (-14.5) vs Penn State: Indiana -14.5
I'm not sure what Penn State has left in the tank after throwing its biggest punch against Ohio State and still coming up way short. The Indiana train rolls on.
Read our full Indiana vs. Penn State predictions.
BYU vs Texas Tech (-10.5): Texas Tech -10.5
BYU has been playing with fire far too often, falling behind in games and needing heroics to stay undefeated to this point. That simply won't work against Texas Tech.
Read our full BYU vs. Texas Tech predictions.
Georgia (-8.5) vs Mississippi State: Mississippi State +8.5
For as tested as Georgia may be, the Bulldogs haven't shown they can dominate teams away from home. And whatever you may think of Texas, Mississippi State had the Longhorns down 17 late in the game before that collapsing late.
Read our full Georgia vs. Mississippi predictions.
Ohio State (-29.5) vs Purdue: Ohio State -29.5
Only two teams have reached 10 points against this Ohio State defense, a stat that's helped the Buckeyes cover in seven of eight games to start the season. I don't imagine Purdue being a third.
Read our full Ohio State vs. Purdue predictions.
Texas A&M (-7.5) vs Missouri: Missouri +7.5
While Texas A&M is a deserving touchdown favorite, Mizzou's only home loss came to Alabama by three points. This is not a surefire win for the Aggies.
Read our full Texas A&M vs. Missouri predictions.
Oregon (-6.5) vs Iowa: Iowa +6.5
For every dominant Oregon performance, there's a confounding one (such as being up 7-0 at halftime against 2-6 Wisconsin). Iowa is quietly 6-2, and this is not an easy place to play; just ask Indiana.
Read our full Oregon vs. Iowa predictions.
LSU vs Alabama (-9.5): LSU +9.5
This line has widened because of the losses ultimately culminating in Brian Kelly's firing, but with the pressure off, this could be the spot to let loose and make Alabama earn it at home. Let's not forget: the Tide looked incredibly beatable against South Carolina two weekends ago.
Read our full LSU vs. Alabama predictions.
Navy vs Notre Dame (-26.5): Notre Dame -26.5
Navy's defense has given up 30+ points in four straight games to North Texas, FAU, Temple, and Air Force. What might we think Notre Dame will do in this game?
Read our full Navy vs. Notre Dame predictions.
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