The defending champion Ohio State Buckeyes will be looking to continue their 12-game winning streak dating back to last season when they travel to take on the Purdue Boilermakers, losers of 15 straight Big Ten games.
The Buckeyes are 7-0-1 against the spread this season, but the Boilermakers have been very competitive in recent weeks.
Find out who I like in my Ohio State vs. Purdue predictions and college football picks for Saturday, November 8.
Want to make sure Covers shows up often in your Google search results and Discover feed?
Simply click here and add Covers as one of your "source preferences".
Ohio State vs Purdue prediction
Ohio State vs Purdue best bet: Julian Sayin Under 2.5 passing touchdowns (+132)
Julian Sayin is having an incredible debut season as the Ohio State Buckeyes quarterback and is now the favorite to win the Heisman trophy. He now has 23 passing touchdowns on the season to only three interceptions.
However, as bad as the Purdue Boilermakers have been with 15 straight losses in conference play, they've been surprisingly good at keeping opposing passes out of the endzone. Not a single opposing quarterback has thrown for more than two touchdown passes in a game this season.
As good as Sayin has been this season, he does have three games with two or fewer passing touchdowns. This game is also likely to be a blowout, and if Sayin doesn’t get his passing touchdowns early, there will be no reason for him to throw late.
The Boilermakers have given up most of their points through the ground game and turnovers. I believe this game script will lead to fewer passing opportunities for Sayin, and we're getting very good odds on him to do something the Boilermakers have forced in every game this season.
Ohio State vs Purdue same-game parlay
To add to my best bet, I'm going to add both Buckeyes running backs to make plays; Bo Jackson to get the yards, and CJ Donaldson to find paydirt.
Ohio State vs Purdue SGP
- Julian Sayin Under 2.5 passing touchdowns
- Bo Jackson Over 70.5 rushing yards
- CJ Donaldson anytime touchdown
Our deep-ball SGP: Bang for your Buckeye!
Jeremiah Smith has been racking up the catches and yards this season, and he'll do so again this weekend against Purdue.
Ohio State vs Purdue SGP
- Julian Sayin Under 2.5 passing touchdowns
- Bo Jackson Over 70.5 rushing yards
- CJ Donaldson anytime touchdown
- Jeremiah Smith Over 85.5 receiving yards
Ohio State vs Purdue odds
- Spread: Ohio State -29.5 | Purdue +29.5
- Moneyline: Ohio State -10000 | Purdue +2500
- Over/Under: Over 48.5 | Under 48.5
Ohio State vs Purdue trend to know
Purdue has cashed the Under in nine of its last 13 games. Find more college football betting trends for Ohio State vs Purdue.
How to watch Ohio State vs Purdue
| Location | Ross-Ade Stadium, West Lafayette, IN |
| Date | Saturday, November 8, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | BTN |
Ohio State vs Purdue latest injuries
Ohio State vs Purdue weather
Monitor gametime conditions with our College football weather info.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
