Oregon vs Iowa Prediction, Picks & Odds for November 8 — College Football Week 11

Yonke's prediction: Kamari Moulton lets loose against Oregon's soft run defense.

JD Yonke - Betting Analyst at Covers.com
JD Yonke • Betting Analyst
Nov 6, 2025 • 10:37 ET • 4 min read

NCAAF

Match starts: 50 hrs
IOWA
37 %
ORE
63 %
EXPERT PICK - PROP
Kamari Moulton o54.5  Rushing Yards (-114) Kamari Moulton o54.5 Rushing Yards (-114)
Read Analysis
Kamari Moulton Iowa Hawkeyes Big Ten college football
Photo By - Imagn Images. Kamari Moulton runs the ball against Penn State.

One of the marquee matchups in college football for Week 11 sees the No. 9 Oregon Ducks face the No. 20 Iowa Hawkeyes at Kinnick Stadium.

Let’s take a closer look at Iowa running back Kamari Moulton’s rushing yardage prop, as Oregon’s defensive philosophy, combined with the weather, means his prop could hold some value. 

See why my Oregon vs. Iowa predictions and college football picks on Saturday, November 8, are bullish on Moulton.

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Oregon vs Iowa prediction

Oregon vs Iowa best bet: Kamari Moulton Over 54.5 rushing yards (-114)

Dan Lanning is a Kirby Smart disciple, who himself is a member of the Nick Saban coaching tree. Lanning has his Oregon Ducks following the same defensive philosophies of his predecessors, especially in operating the Mint defense. 

Put simply, Oregon recognizes that, in the modern game of college football, games are won and lost through the air — not the ground. The Ducks are content to allow opponents to gain yardage by running the ball, so long as they devote extra bodies to slowing down the pass. 

As it seems to happen every year (ahem, not a coincidence), Oregon’s numbers are much better against the pass (eighth in EPA per pass allowed) than the run (80th). It’s a comical stylistic clash in Week 11 because the Iowa Hawkeyes are generally content to keep the ball on the ground, and they’ll likely take what’s given to them.

Running back Kamari Moulton has seen steady volume (14+ carries in five consecutive games) and has responded with consistent production (68+ rushing yards in all five). His rushing yardage prop of 54.5 does not make sense considering his opponent’s defensive philosophy and his own recent effectiveness.

Oregon vs Iowa same-game parlay

Moulton’s rushing yardage prop doesn’t correlate with either moneyline side, in my opinion, as Oregon has been winning darn near every football game it's played for the last three years, all while having underwhelming rushing defense metrics. 

The Ducks are the superior team, possessing quality on both sides of the ball (second in EPA per play on offense, 15th on defense), whereas the Hawkeyes lag behind offensively because they create the least explosive plays of any team in the country. 

It’ll be a cold (42 to 46 degrees), windy (9 to 11 mph), and rainy (73%) day at Kinnick Stadium, and neither team plays at a fast tempo, so points will be at a premium.

Oregon vs Iowa SGP

  • Kamari Moulton Over 54.5 rushing yards
  • Under 40.5
  • Oregon moneyline

Our deep-ball SGP: Mark my words!

Although Moulton has been the consistent yardage producer on the ground, quarterback Mark Gronowski has been the goal-line vulture. Gronowski has 11 touchdowns to Moulton’s two, and the signal-caller has found the end zone in every game this season.

Oregon vs Iowa SGP

  • Kamari Moulton Over 54.5 rushing yards
  • Mark Gronowski anytime touchdown
  • Under 40.5
  • Oregon moneyline

Oregon vs Iowa odds

  • Spread: Oregon -6.5 | Iowa +6.5
  • Moneyline: Oregon -235 | Iowa +200
  • Over/Under: Over 40.5 | Under 40.5

Oregon vs Iowa trend to know

Kamari Moulton has rushed for more than 54.5 yards in five consecutive games. Find more college football betting trends for Oregon vs Iowa.

How to watch Oregon vs Iowa

Location Kinnick Stadium, Iowa City, IA
Date Saturday, November 8, 2025
Kickoff 3:30 p.m. ET
TV CBS

Oregon vs Iowa latest injuries

Oregon vs Iowa weather

Monitor gametime conditions with our College football weather info.

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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JD Yonke
Betting Analyst

JD is a diehard college football fan with five years of experience writing betting and fantasy content for publications such as SportsGrid, Fantasy Points, Fantrax, and Devy Watch. An avid reader, he uses his inclination to look at things with an exhausting and in-depth, analytic viewpoint combined with a love for statistics and metrics to form a well-rounded handicapping approach.

e's an integral member of the niche (but growing!) college fantasy football community, twice traveling to Canton, OH for the Fantasy Football Expo as a member of the CFF King's Classic drafting squad. His specialization in college football DFS and prop betting taught him that there are exploitable markets to be found and that narrowing your focus is integral to being a profitable bettor.

A lifelong Californian who grew up playing baseball, basketball, football, and lacrosse, he's glad to share a passionate love for sports with this wonderful community.

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