College Football Week 7 Against the Spread Picks for the Biggest Games

Ohio State and Oregon are both entering Week 7 undefeated, but that's set to change with the two Big Ten beasts facing off in Eugene this weekend. That game highlights our Week 7 ATS picks below.

Chris Gregory - Publishing Editor at Covers.com
Chris Gregory • Publishing Editor
Oct 8, 2024 • 14:32 ET • 4 min read
Quinshon Judkins Ohio State Buckeyes Big Ten college football
Photo By - USA TODAY Sports

After the absolute bloodbath of upsets that came in Week 6, it's time to turn the page to the Week 7 college football odds.

The marquee matchup sees No. 2 Ohio State hitting the highway to take on No. 3 Oregon in Eugene. I pick a winner for that game and much more in my ATS college football picks below.

College football Week 7 picks against the spread

Matchup Pick
NFC South Carolina vs Alabama Alabama NFC +21
Clemson Clemson vs Wake Forest Wake Forest Clemson -20
Texas Texas vs Oklahoma Oklahoma Texas -14.5
Penn State Penn State vs USC USC USC +5
Mississippi State Mississippi State vs Georgia Georgia Mississippi State +33.5
Florida Florida vs Tennessee Tennessee Florida +15
Ohio State Ohio State vs Oregon Oregon Ohio State -3
Mississippi Mississippi vs LSU LSU Mississippi -3.5
Kansas State Kansas State vs Colorado Colorado Kansas State -3.5

Lines courtesy of DraftKings as of 10/8.

CFB Week 7 ATS picks

South Carolina vs Alabama (-21): South Carolina +21

What seems like an obvious bounce-back spot for Bama might not be quite as it seems. Despite South Carolina getting rocked by Mississippi last week, this is still an underrated — and now desperate — team in the SEC.

Clemson (-20) vs Wake Forest: Clemson -20

Clemson has now won four straight games by an average of 28 points and is 3-1 ATS over that span. Wake beating NC State is impressive on paper but much less so when you factor in Grayson McCall's injury.

Texas (-14.5) vs Oklahoma: Texas -14.5

There's simply no reason to stop backing the Longhorns, who failed to cover for the first time in Week 5 and will have Quinn Ewers back under center after a bye in Week 6. Lay the number. 

Penn State (-5) vs USC: USC +5

It would be easy to lean toward the undefeated Nittany Lions, but I'm happy to take the points with the Trojans inside the Coliseum, where they're 3-0 SU and 3-0 ATS this season.

Mississippi State vs Georgia (-33.5): Mississippi State +33.5

This is a massive number for a Georgia team that has just a +12 point differential in three SEC games this season. Mississippi State held No. 1 Texas to 35 points at home in a 22-point loss two weeks ago (albeit without Quinn Ewers). 

Florida vs Tennessee (-15): Florida +15

The sentiment around Tennessee's offense has been flipped on its head over the last two weeks, so much so that covering a three-score spread becomes a much tougher task. For all its flaws, Florida has scored 69 points over its last two wins (vs. UCF, at Miss State).

Ohio State (-3) vs Oregon: Ohio State -3

In by far the game of the week, the Buckeyes are off to Eugene for their first true test. Oregon has shed some of its early-season rust, but this is still a team that's just 1-4 ATS this season. Give me the Buckeyes 31-23. 

Mississippi (-3.5) vs LSU: Mississippi -3.5

With LSU high on my list of untrustworthy teams, this is an easy choice. The Rebels dominated South Carolina to get back in the win column, and I expect another encouraging result here. 

Kansas State (-3.5) vs Colorado: Kansas State -3.5

Colorado's 48-21 win over UCF is particularly impressive but I expect things to come undone against what might be the best team in the Big 12. 

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Chris Gregory Covers.com
Publishing Editor

In his three years on the Covers editorial team, Chris Gregory has helped bolster the site’s PGA Tour and college football coverage, though his love for Rory McIlroy and the Buckeyes is often met with disappointment. He brings a journalism and marketing background to his work as a Publishing Editor and has appeared on Jason Logan’s Sharp 600 to talk about the Masters and golf’s other majors.

His best betting advice? Stay away from betting your favorite teams; it’ll only make the hurt worse.

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