Here are a couple of fearless predictions: The New York Yankees will give up a run at some point this season. And the San Francisco Giants will score one.
When either will happen, we're not entirely sure.
The Giants opened the season getting shut out in back-to-back games for the first time, mustering a total of four hits.
The pitching matchup is in favor of some more scoring on Saturday, but my Yankees vs. Giants predictions and MLB picks have the Yankees winning again.
Yankees vs Giants predictions
Yankees vs Giants best bet: Yankees moneyline (-130)
Everything has come up good for the New York Yankees in the season's first two games. New York pitchers have struck out 19 in 18 shutout innings and allowed one extra-base hit.
Will Warren, Saturday's starter, has been solid for the Yankees but not on the level of their first two starters. He adjusted his delivery, resulting in a 1.42 ERA spring ERA.
The San Francisco Giants, meanwhile, are already showing signs of frustration. Losing pitcher Robbie Ray seemed to take issue with former college coach Tony Vitello's rah-rah clubhouse speeches after yesterday's game.
COVERS INTEL: The Giants are 0-7 with runners in scoring position through the first two games of this series with the Yankees. 
Yankees vs Giants same-game parlay (SGP)
After two pitching masterpieces, we could be in store for a slugfest. Warren was two full runs worse on the road last year (5.52 ERA compared to 3.50 at home). His WHIP was .571 higher, and opponents had 157 more points of OPS against him in road games.
Giants starter Tyler Mahle, an offseason acquisition after a strong year with Texas, has a 5.13 career ERA in his new home park, allowing four home runs in five starts. So, the Yankees should also be able to put up plenty of runs.
Yankees vs Giants SGP
- Yankees moneyline
- Will Warren over 2.5 earned runs allowed
- Over 8.5 total runs
Yankees vs Giants home run pick: Aaron Judge (+220)
Judge should probably always be the home run pick in a Yankee game, but he's been even better in his hometown park. Friday's blast was his fourth in five games in San Francisco, and his 1.455 OPS at Oracle Park is fifth highest in any stadium—and Coors Field is one of the four where he's hit better.
He's also a streaky home-run hitter. Over the last two seasons, 39 of his 111 home runs have come after he's already homered within the last day. He went deep on Friday.
- Best bets: 0-3, -3.0 units
- SGPs: 0-3, -3.0 units
- HR picks: 1-2, +1.25 units
Yankees vs Giants odds
- Moneyline: New York -125 | San Francisco +113
- Run line: New York -1.5 (+135) | San Francisco +1.5 (-155)
- Over/Under: Over 8 (+100) | Under 8 (-120)
Yankees vs Giants trend
The New York Yankees have hit the Team Total Over in 18 of their last 23 away games. Find more MLB betting trends for Yankees vs. Giants.
How to watch Yankees vs Giants and game info
| Location | Oracle Park, San Francisco, CA |
| Date | Saturday, March 28, 2026 |
| First pitch | 7:15 p.m. ET |
| TV | FOX |
| Yankees starting pitcher | Will Warren (2025: 9-8, 4.44 ERA) |
| Giants starting pitcher | Tyler Mahle (6-4, 2.18 ERA) |
Yankees vs Giants latest injuries
Yankees vs Giants weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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