The Boston Red Sox are significant -190 favorites against the Chicago White Sox, and rightfully so.
I see edges for Boston across the board, and am attacking the run line with my White Sox vs. Red Sox predictions and MLB picks for Thursday, Aug. 6.
Who will win White Sox vs Red Sox today: Red Sox -1.5 (+105)
The Chicago White Sox rank dead last in ISO against lefties over the last month, and there’s no reason to expect any boost in power against Ranger Suarez.
He ranks in the 89th percentile in barrel rate allowed and has conceded 0.45 HR/9 on the season.
Scoring against Suarez will be like pulling teeth, and Chicago will have to contend with the league’s best bullpen by xFIP after he exits.
The Boston Red Sox are in a great spot to produce against Luis Castillo, who owns an alarming 1.71 WHIP the past 30 days.
Play the run line to -110.
COVERS INTEL: Castillo has allowed an alarming 3.71 HR/9 the past month, and the Red Sox are tied for ninth in homers against righties during that span.
White Sox vs Red Sox Over/Under pick: Under 9 (-115)
Chicago is hitting for zero power against lefties, and it has struck out at the ninth-highest rate the last month. That sets up well for Suarez and his career-best 25.7 K rate — not to mention Boston’s strikeout-heavy bullpen.
The Red Sox are admittedly in a good matchup against Castillo, but I’m not sure it will matter. I project the White Sox for less than three runs, meaning the Red Sox would have to plate seven to push this game Over.
I see a big edge on this total, and would recommend the Under to -130.
- ML/RL bets: 70-65, -9.75 units
- Over/Under bets: 75-54-6, +12.24 units
White Sox vs Red Sox weather
Temperatures in the mid 80s with slight winds blowing out will provide a boost to the bats.
White Sox vs Red Sox odds
- Moneyline: White Sox +160 | Red Sox -190
- Run line: White Sox +1.5 (-125) | Red Sox -1.5 (+105)
- Over/Under: Over 9.0 (-105) | Under 9.0 (-115)
White Sox vs Red Sox trend
Boston has hit the run line in 28 of its last 45 games (+14.00 units, 24% ROI). Find more MLB betting trends for White Sox vs. Red Sox.
How to watch White Sox vs Red Sox and game info
| Location | Fenway Park, Boston, MA |
| Date | Thursday, August 6, 2026 |
| First pitch | 7:10 p.m. ET |
| TV | CHSN, NESN |
| White Sox starting pitcher | Luis Castillo (3-9, 5.06 ERA) |
| Red Sox starting pitcher | Ranger Suarez (4-3, 3.15 ERA) |
White Sox vs Red Sox latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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