Two slumping teams meet tonight at Camden Yards as the Detroit Tigers visit the Baltimore Orioles for the first of a three-game set. The first pitch is scheduled for 7:15 p.m. ET.
My Tigers vs. Orioles predictions are targeting Baltimore to hand Detroit their seventh straight loss behind Chris Bassitt's excellence at home.
Read more in my MLB picks for Friday, May 22.
Who will win Tigers vs Orioles today: Orioles moneyline (-126)
Detroit Tigers SP Jack Flaherty sports a poor 5.70 ERA, with a 14.1% walk rate, through 10 starts — and opponents are hitting .295 against him when he's on the road.
The Baltimore Orioles lineup has also had success vs. the righty, hitting .308 across 26 at-bats. Pete Alonso alone is 3-for-6.
As for the O's, Chris Bassitt gets the baseball, and he's compiled a 2.91 ERA across four appearances at home. To put that into perspective, his ERA sits above eight on the road.
The Tigers are struggling immensely at the dish right now, scoring just eight runs in their previous series with the Guardians.
COVERS INTEL: Flaherty has a career-worst 45% hard hit rate this season. 
Tigers vs Orioles Over/Under pick: Under 8.5 (-106)
It's rarely high-scoring when the Tigers and Orioles clash. Six of the last seven meetings have comfortably cashed the Under.
Detroit and Baltimore have both hit the Under in seven of their last 10.
While the pitching matchup could mean offense, I'm focused on Bassitt's impressive form at Camden Yards.
He's looked like a completely different pitcher in front of the O's faithful, and he's coming up against a Tigers lineup that looks utterly hopeless at the moment.
Detroit ranks 28th in the big leagues in runs scored, while the O's are 16th.
- ML/RL bets: 15-11, +4.72 units
- Over/Under bets: 15-11, +2.09 units
Tigers vs Orioles odds
- Moneyline: Tigers +117 | Orioles -122
- Run line: Tigers +1.5 (-178) | Orioles -1.5 (+170)
- Over/Under: Over 8.5 (+104) | Under 8.5 (-108)
Tigers vs Orioles trend
The Orioles have hit the Under in 10 of their last 13 games (+7.70 Units / 54% ROI). Find more MLB betting trends for Tigers vs. Orioles.
How to watch Tigers vs Orioles and game info
| Location | Oriole Park at Camden Yards, Baltimore, MD |
| Date | Friday, May 22, 2026 |
| First pitch | 7:15 p.m. ET |
| TV | Apple TV |
| Tigers starting pitcher | Jack Flaherty (0-5, 5.77 ERA) |
| Orioles starting pitcher | Chris Bassitt (3-3, 5.44 ERA) |
Tigers vs Orioles latest injuries
Tigers vs Orioles weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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