The Tampa Bay Rays' starting pitching has dominated the Cleveland Guardians through the first two games of this series.
My Rays vs. Guardians predictions call for a series sweep for Tampa, with Drew Rasmussen on the mound.
Read on for my MLB picks for Wednesday, April 29.
Who will win Rays vs Guardians today: Rays (+105)
Drew Rasmussen is pitching like an ace with an 88th-percentile xERA, 96th-percentile walk rate, and the Cleveland Guardians are hitting .167 against him career, with zero extra-base hits in 36 career at-bats.
The Guardians have scored just seven runs in their previous four games, while the Tampa Bay Rays offense scores just enough to win and owns a career 1.070 OPS in 34 career at-bats against Gavin Williams.
The Rays' pitching in this series has been outstanding. Tampa Bay is hot, and Cleveland can’t string two hits together. Back the Rays to sweep.
COVERS INTEL: The Rays are hitting a seventh-best .275 with runners in scoring position. 
Rays vs Guardians Over/Under pick: Over 6.5 (-114)
Williams looks great on paper, but Tampa Bay has tattooed him.
Yandy Díaz is hitting .500 against him in 12 ABs, and the righty has walked more Rays hitters than he has struck out.
Once Rasmussen exits, the Tampa bullpen becomes a liability that Cleveland might exploit.
One crooked number from the Rays early and a few runs against the pen late make this total very reachable. Back the Over.
- ML/RL bets: 4-8, -3.20 units
- Over/Under bets: 5-6, -1.16 units
Rays vs Guardians odds
- Moneyline: Rays +104 | Guardians -108
- Run line: Rays -1.5 (+194) | Guardians +1.5 (-203)
- Over/Under: Over 6.5 | Under 6.5
Rays vs Guardians trend
The Tampa Bay Rays are riding a six-game winning streak heading into today’s contest with the Guardians. Find more MLB betting trends for Rays vs. Guardians.
How to watch Rays vs Guardians and game info
| Location | Progressive Field, Cleveland, OH |
| Date | Wednesday, April 29, 2026 |
| First pitch | 1:10 p.m. ET |
| TV | Rays.TV, Guardians.TV |
| Rays starting pitcher | Drew Rasmussen (2-0, 2.45 ERA) |
| Guardians starting pitcher | Gavin Williams (4-1, 3.28 ERA) |
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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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