The Los Angeles Dodgers hope to break out of a funk as Shohei Ohtani takes the mound for Game 2 of their series against the San Francisco Giants.
Tony Vitello’s built some much-needed momentum with a series-opening victory, however, and his squad is laser-focused on this rivalry series as a turning point in the young season.
My Dodgers vs. Giants predictions and MLB picks are backing the underdog on Wednesday, April 22.
Who will win Dodgers vs Giants today: Giants (+186)
The odds indicate that this is supposed to be a squash match for the Los Angeles Dodgers.
Shohei Ohtani’s pristine 0.50 ERA stands in stark contrast to Tyler Mahle’s (7.23), so the market expects a bounce-back from L.A. after Tuesday’s 3-1 defeat.
Mahle’s due for positive regression, however, as he pitched to a 2.18 ERA across 16 starts a year ago and will benefit from the confines of pitcher-friendly Oracle Park.
Ohtani’s control (94 Location+) hasn’t come back to bite him yet, but that and his unsustainable .158 BABIP indicate his pretty ERA will creep up eventually.
COVERS INTEL: Tyler Mahle has found success against some of L.A.’s best hitters in the past. He’s held Ohtani, Kyle Tucker, and Max Muncy to six hits in 29 at-bats (.207 AVG) with 10 strikeouts.
Dodgers vs Giants Over/Under pick: Under 7.5 (+108)
The first game of this series flew Under the total in a low-scoring 3-1 San Francisco Giants win, and a similar result could be in store during a chilly Wednesday night in San Francisco.
Temperatures in the high-50s for most of this contest will benefit both starting pitchers as well as the two Top-10 bullpens behind them (LAD 3.49 SIERA in relief; SFG 3.59).
L.A. is in a bit of a slump, dropping three of its last four games while missing Mookie Betts and Tommy Edman in the lineup. San Francisco, meanwhile, has yet to get the bats going against right-handed pitching (79 wRC+).
- ML/RL bets: 7-5, +3.08 units
- Over/Under bets: 8-5, +2.74 units
Dodgers vs Giants odds
- Moneyline: Dodgers -200 | Giants +190
- Run line: Dodgers -1.5 (-120) | Giants +1.5 (-105)
- Over/Under: Over 7.5 | Under 7.5
Dodgers vs Giants trend
The Dodgers have dropped three of their last four games, costing one-unit bettors a 5.75 unit loss. Find more MLB betting trends for Dodgers vs. Giants.
How to watch Dodgers vs Giants and game info
| Location | Oracle Park, San Francisco, CA |
| Date | Wednesday, April 22, 2026 |
| First pitch | 9:45 p.m. ET |
| TV | Sportsnet-Los Angeles, NBCS-Bay Area |
| Dodgers starting pitcher | Shohei Ohtani (2-0, 0.50 ERA) |
| Giants starting pitcher | Tyler Mahle (0-3, 7.23 ERA) |
Dodgers vs Giants latest injuries
Dodgers vs Giants weather
Odds are correct at the time of publishing and are subject to change.
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