The Chicago Cubs and San Diego Padres have split the first two of their three-game set and will play the series finale at Petco Park on Wednesday, April 29.
My top Cubs vs. Padres predictions and MLB picks are calling for Chicago to put too many crooked numbers on the scoreboard for San Diego to keep up this afternoon.
Who will win Cubs vs Padres today: Cubs moneyline (-108)
The Chicago Cubs are rolling at the dish during their 14-6 heater with the highest wOBA in baseball and an average of 6.2 runs per game.
Facing San Diego Padres knuckleballer Matt Waldron shouldn’t be too high a hurdle on Wednesday afternoon, either. He sports a career 5.19 ERA and 4.53 xFIP across 201 1/3 innings in the majors.
Finally, I particularly value the sustainable surface of the Chicago offensive success, with the Cubbies sporting the fifth-highest walk rate and fifth-lowest strikeout percentage during the 20-game stretch.
COVERS INTEL: The Cubs have a 60% Pythagorean winning percentage, matching their 18-12 record, and showing that their success is sustainable.
Cubs vs Padres Over/Under pick: Over 9 (-105)
In addition to Chicago being positioned to put runs on the board, San Diego is set up to chip in offensively as well.
Cubbies veteran Jameson Taillon is sporting a 4.55 ERA and 4.80 xFIP through five starts, and his fastball velocity is down to a career-low 91.5 mph.
Chicago has also played to the Over in 16 of its past 23 games (+9.40 units / 37% ROI), and there have already been 27 runs through the first two games of this series.
- ML/RL bets: 13-8, +6.29 units
- Over/Under bets: 5-6, -1.94 units
Cubs vs Padres odds
- Moneyline: Cubs -115 | Padres -105
- Run line: Cubs -1.5 (+140) | Padres +1.5 (-170)
- Over/Under: Over 9 (-105) | Under 9 (-115)
Cubs vs Padres trend
The Chicago Cubs have won 11 of their last 14 games (+8.75 Units / 53% ROI). Find more MLB betting trends for Cubs vs. Padres.
How to watch Cubs vs Padres and game info
| Location | Petco Park, San Diego, CA |
| Date | Wednesday, April 29, 2026 |
| First pitch | 4:10 p.m. ET |
| TV | MARQ, Padres.TV |
| Cubs starting pitcher | Jameson Taillon (1-1, 4.55 ERA) |
| Padres starting pitcher | Matt Waldron (0-1, 12.46 ERA) |
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Odds are correct at the time of publishing and are subject to change.
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