The Milwaukee Brewers are a modest home favorite to sweep their three-game series against the Chicago Cubs ahead of the 7:40 p.m. ET first pitch at American Family Field on Wednesday, Sept. 9.
My top Cubs vs. Brewers predictions and MLB picks anticipate the two offenses sending this total Over the number in a Cubs win tonight.
Who will win Cubs vs Brewers today: Cubs moneyline (45.9%)
For help understanding probabilities, see our odds calculator.
The Chicago Cubs have taken consecutive tough-luck losses, and I’m anticipating veteran righty Kevin Gausman building off his statement start against the Milwaukee Brewers last time out to lead the North Siders to victory tonight.
Chicago has stranded 17 runners through the first two games of the series, and it’ll see Milwaukee righty Logan Henderson for the second time in less than a week.
The Cubbies are fifth in wOBA and third in ISO against righties for the campaign, and they also pace the majors in xwOBA and wRC+ over the past 30 days, so I’m expecting them to plate more base runners in the series finale.
Finally, with a travel day ahead, I expect the Cubbies to leave it all on the field to avoid a series sweep, and I'd back the Chicago moneyline at 48.8%.
COVERS INTEL: The Chicago Cubs and Milwaukee Brewers respectively rank first and fourth in wOBA and second and first in on-base percentage this season.
Cubs vs Brewers Over/Under pick: Over 7.5 (51.2%)
In addition to the highlighted success of the Chicago offense, the Brewers have also been rolling at the dish.
Milwaukee paces the majors in wOBA against right-handed pitchers for the year, and they also rank second in wOBA and eighth in xwOBA over the past 30 days.
The Cubbies have played to the Over in 23 of their last 40 games (+6.70 Units / 15% ROI), too, so I’d recommend the Over 7.5 to 53.5%.
Cubs vs Brewers home run prediction: Pete Crow-Armstrong (23.9%)
Cubbies star Pete Crow-Armstrong took Henderson deep last week, and his .316 ISO against righties is second in the majors.
Additionally, Crow-Armstrong paces the league with 20 homers and a .395 ISO in the second half.
- ML/RL bets: 55-28, +29.26 units
- Over/Under bets: 28-26, +0.62 units
Cubs vs Brewers weather
The roof is expected to be closed at American Family Field tonight because of lingering cloudy conditions and a 20-35% chance of scattered morning or early-evening showers, with the climate-controlled indoor temperature set to a perfect 72°F.
Status of the movable roof at American Family Field is available on the official website of the Milwaukee Brewers.
Cubs vs Brewers odds
- Moneyline: Cubs 47.6% | Brewers 56.5%
- Run line: Cubs +1.5 (64.3%) | Brewers -1.5 (39.2%)
- Over/Under: Over 7.5 (52.5%) | Under 7.5 (52.5%)
Cubs vs Brewers trend
The Chicago Cubs have won 25 of their past 40 road games (+8.85 Units / 18% ROI). Find more MLB betting trends for Cubs vs. Brewers.
How to watch Cubs vs Brewers and game info
| Location | American Family Field, Milwaukee, WI |
| Date | Wednesday, September 9, 2026 |
| First pitch | 7:40 p.m. ET |
| TV | MARQ, Brewers.TV |
| Cubs starting pitcher | Kevin Gausman (9-11, 4.38 ERA) |
| Brewers starting pitcher | Logan Henderson (9-3, 2.48 ERA) |
Cubs vs Brewers latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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