The weekend series between the Cardinals and Reds will finally start with a day-night doubleheader on Saturday, May 23. The foul weather changed the pitching matchup for the nightcap, and injured list moves on both teams have tweaked the rosters.
The results of both lean in Cincinnati’s favor, as my Cardinals vs. Reds predictions and MLB picks for Game 2 explain.
Who will win Cardinals vs Reds tonight: Reds moneyline (-105)
Andre Pallante was initially scheduled to start for the St. Louis Cardinals on Saturday, but with the rain, the Redbirds flipped the rotation.
The Cincinnati Reds will now face his 95th percentile breaking ball and 89th percentile ground ball rate in Game 1.
That pushes the more hittable Kyle Leahy to the nightcap. Leahy is in the Bottom 20% in MLB in fastball and offspeed run value, and allows more hits, walks, and homers than Pallante.
The Reds also get Eugenio Suarez back, while the Cardinals placed outfielder Nathan Church on IL.
COVERS INTEL: Opponents have a .584 OPS in their first appearance vs. Leahy, which rises to .821 the next time up, and 1.177 the third time up.
Cardinals vs Reds Over/Under pick: Over 9.5 (-105)
The Over/Under cutoff is high, but it’s earned in this game. The bullpens will be taxed in the second game of a twin bill, and Leahy will be challenged by a Reds order hitting 25% over league average across the last two weeks.
St. Louis has been struggling on offense, but the Reds will start former top pick Chase Petty, called up for the doubleheader and ready to make just his fourth MLB start.
He’s allowed four home runs and 10 walks in 11 2/3 big-league innings and was struggling at Triple-A Louisville, with a 6.32 ERA and 1.628 WHIP.
- ML/RL bets: 15-19 -3.28 units
- Over/Under bets: 19-19 -1.51 units
Cardinals vs Reds odds
- Moneyline: Cardinals -110 | Reds -110
- Run line: Cardinals +1.5 | Reds -1.5
- Over/Under: Over 9.5 | Under 9.5
Cardinals vs Reds trend
The Reds have hit the Over in 28 of their last 40 games (+14.55 Units / 33% ROI). Find more MLB betting trends for Cardinals vs. Reds.
How to watch Cardinals vs Reds and game info
| Location | Great American Ballpark, Cincinnati, OH |
| Date | Saturday, May 23, 2026 |
| First pitch | 7:15 p.m. ET |
| TV | FOX |
| Cardinals starting pitcher | Kyle Leahy (5-3, 3.94 ERA) |
| Reds starting pitcher | Chase Petty (0-0, 4.76 ERA) |
Cardinals vs Reds latest injuries
Cardinals vs Reds weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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