This afternoon's matchup features the league's ERA leader in Jose Soriano and hits leader in Vladimir Guerrero Jr., and I’m expecting the Toronto Blue Jays slugger to win the best-on-best battle.
Read more in my Blue Jays vs. Angels predictions and MLB picks below.
Blue Jays vs Angels predictions
Blue Jays vs Angels best bet: Vladimir Guerrero Jr. Over 1.5 total bases (+135)
You’re getting great value on Vladimir Guerrero Jr. at +135 to go Over his bases total tonight against a pitcher with a 0.28 ERA.
Vladdy is 2-for-2 with a walk in three plate appearances against Jose Soriano, and Soriano's most-used pitch is a sinker-ball, a pitch that Guerrero owns a .444 batting average with a 55% hard-hit rate against.
I’m expecting Guerrero Jr. to continue this trend as he's one of baseball’s best hitters.
Vladdy is hitting an MLB-best .353 this season, while riding a 12-game hitting streak, averaging 2.41 bases per contest in that stretch.
COVERS INTEL: Vladimir Guerrero Jr. owns a 1.117 OPS during this current 12-game hitting streak.
Blue Jays vs Angels same-game parlay (SGP)
I’ll continue to bank on the Toronto Blue Jays bats this afternoon. For the second leg of my SGP, I’ll take Daulton Varsho to go Over 0.5 hits. He’s 2-for-4 with a double and an RBI against Soriano throughout his career and has recorded a hit in eight of his last 10 games.
Lastly, I’ll also bet on Ernie Clement to record a hit as well. Clement has been a hitting machine, going Over his 0.5 total in 19 of 23 games this season, totaling 29 hits this year, which is only one shy of the league lead.
Additionally, he has recorded one hit against Soriano and three at-bats against him.
Blue Jays vs Angels SGP
- Vladimir Guerrero Jr. Over 1.5 total bases
- Daulton Varsho Over 0.5 hits
- Ernie Clement Over 0.5 hits
Blue Jays vs Angels home run pick: Daulton Varsho (+510)
I’ll make this a half-unit wager. Varsho brings a lot of pop from the left side of the plate, and Soriano has given up a little bit more power to lefties than righties this season.
Albeit, it’s still not a whole lot of power as Soriano doesn’t slow for hard contact, allowing just one home run on the year.
However, Varsho does seem to see the sinker well out of the pitcher's hand, which is the most used pitch Soriano throws against lefties. The Jays outfielder owns a .438 batting average and a .688 slugging percentage against the pitch.
- Best bets: 5-17, -9.35 units
- SGPs: 2-20, -12.5 units
- HR picks: 4-18, -0.35 units
Blue Jays vs Angels odds
- Moneyline: Toronto +135 | Los Angeles -160
- Run line: Toronto +1.5 (-160) | Los Angeles -1.5 (+135)
- Over/Under: Over 8.5 | Under 8.5
Blue Jays vs Angels trend
The Blue Jays have cashed the first five innings team total Under in nine of their last 11 road games for +7.55 units and a 55% ROI. Find more MLB betting trends for Blue Jays vs. Angels.
How to watch Blue Jays vs Angels and game info
| Location | Angel Stadium, Anaheim, CA |
| Date | Wednesday, April 22, 2026 |
| First pitch | 3:07 p.m. ET |
| TV | FDSN W, SN |
| Blue Jays starting pitcher | Eric Lauer (1-3, 7.13 ERA) |
| Angels starting pitcher | Jose Soriano (5-0, 0.28 ERA) |
Blue Jays vs Angels latest injuries
Blue Jays vs Angels weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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