The Chicago Cubs will try to snap a six-game losing streak when they take on the Houston Astros today.
With Colin Rea on the mound at Wrigley, my Astros vs. Cubs predictions and free MLB picks for Saturday, May 23 see Chicago stopping their skid.
Who will win Astros vs Cubs today: Cubs moneyline (-142)
Colin Rea has a 2.66 ERA at home this season, allowing four earned runs in the last three starts covering 17 innings.
The Houston Astros are in the bottom half of MLB in scoring, and are hitting .214 in May. At 9-17, they have the second-fewest road wins in the American League.
The Chicago Cubs have won three of the last four in this head-to-head at home, averaging four runs a game. That should be enough to even this series.
COVERS INTEL: Five of Houston’s Top 6 hitters are right handed, and Rea has handled righties well this year, limiting them to a .333 SLG.
Astros vs Cubs Over/Under pick: Under 7.5 (-115)
The Cubs' offense has dried up, as they’ve scored two runs or fewer in eight of their last 12.
Houston sends converted reliever Kai-Wei Teng to the bump, and he's 1-0 with a 0.90 ERA through three starts, posting 10.8 strikeouts per nine innings.
This pitching matchup should help continue the trend of cashing the Under in this head-to-head, which has a 5-2 record in the last seven meetings.
Houston also has an impressive 8-0-1 Under record in its last nine.
- ML/RL bets: 8-6, +1.99 units
- Over/Under bets: 10-3, +6.74 units
Astros vs Cubs odds
- Moneyline: Astros +133 | Cubs -138
- Run line: Astros +1.5 | Cubs -1.5
- Over/Under: Over 7.5 | Under 7.5
Astros vs Cubs trend
Seven of Chicago's last eight games vs. AL West opponents have gone Under the total. Find more MLB betting trends for Astros vs. Cubs.
How to watch Astros vs Cubs and game info
| Location | Wrigley Field, Chicago, IL |
| Date | Saturday, May 23, 2026 |
| First pitch | 2:20 p.m. ET |
| TV | Space City HN, Marquee |
| Astros starting pitcher | Kai-Wei Teng (2-3, 2.61 ERA) |
| Cubs starting pitcher | Colin Rea (4-2, 4.98 ERA) |
Astros vs Cubs latest injuries
Astros vs Cubs weather
Odds are correct at the time of publishing and are subject to change.
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