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MLB Picks

Get free expert and computer MLB picks for every game on Sept. 25, 2026.

New Computer Picks powered by Odds Shark

Predicted Score

CLE logo
CLE
CLE

4.14 @ 3.98

KC
KC logo
KC

Guardians vs Royals · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CLE logo
CLE
CLE

4.14

-136

o7.0 -113

-1.5 +131

KC logo
KC
KC

3.98

+125

u7.5 -122

+1.5 -137

Colorado @ Chi. White Sox
Matchup Stats

Predicted Score

COL logo
COL
COL

3.86 @ 5.16

CHW
CHW logo
CHW

Rockies vs White Sox · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

COL logo
COL
COL

3.86

+210

o8.0 -110

+1.5 -103

CHW logo
CHW
CHW

5.16

-225

u8.5 -115

-1.5 -110

Top Projection Mickey Moniak o0.5 Total RBIs (+300)
o0.5+300
St. Louis @ Milwaukee
Matchup Stats

Predicted Score

STL logo
STL
STL

3.74 @ 4.32

MIL
MIL logo
MIL

Cardinals vs Brewers · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

STL logo
STL
STL

3.74

+160

o7.5 -110

+1.5 -127

MIL logo
MIL
MIL

4.32

-182

u8.0 -124

-1.5 +120

Top Projection Jordan Walker o0.5 Total RBIs (+168)
o0.5+185
Texas @ Minnesota
Matchup Stats

Predicted Score

TEX logo
TEX
TEX

4.24 @ 3.62

MIN
MIN logo
MIN

Rangers vs Twins · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

TEX logo
TEX
TEX

4.24

-120

o7.0 -115

-1.5 +143

MIN logo
MIN
MIN

3.62

+108

u7.5 -125

+1.5 -155

Top Projection Corey Seager o0.5 Total RBIs (+180)
o0.5+180
Houston @ Athletics
Matchup Stats

Predicted Score

HOU logo
HOU
HOU

6.80 @ 4.89

ATH
ATH logo
ATH

Astros vs Athletics · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

HOU logo
HOU
HOU

6.80

-175

o9.0 -105

-1.5 -110

ATH logo
ATH
ATH

4.89

+160

u9.5 -128

+1.5 -105

Top Projection Shea Langeliers o0.5 Total RBIs (+166)
o0.5+175
Arizona @ San Diego
Matchup Stats

Predicted Score

AZ logo
AZ
AZ

4.20 @ 4.03

SD
SD logo
SD

Diamondbacks vs Padres · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

AZ logo
AZ
AZ

4.20

+115

o7.5 -109

+1.5 -180

SD logo
SD
SD

4.03

-130

u7.5 -105

-1.5 +165

Top Projection Gabriel Moreno o0.5 Total RBIs (+236)
o0.5+245
LA Angels @ Seattle
Matchup Stats

Predicted Score

LAA logo
LAA
LAA

3.68 @ 3.56

SEA
SEA logo
SEA

Angels vs Mariners · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

LAA logo
LAA
LAA

3.68

+104

o6.5 -110

+1.5 -200

SEA logo
SEA
SEA

3.56

-115

u6.5 +100

-1.5 +175

Top Projection Josh Lowe o0.5 Total RBIs (+350)
o0.5+350
LA Dodgers @ San Francisco
Matchup Stats

Predicted Score

LAD logo
LAD
LAD

5.77 @ 2.56

SF
SF logo
SF

Dodgers vs Giants · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

LAD logo
LAD
LAD

5.77

-300

o7.5 +100

-2.5 -104

SF logo
SF
SF

2.56

+275

u8.0 -120

+2.5 -102

Top Projection Teoscar Hernandez o0.5 Total RBIs (+190)
o0.5+190
Pittsburgh @ Detroit
Matchup Stats

Predicted Score

PIT logo
PIT
PIT

4.36 @ 4.39

DET
DET logo
DET

Pirates vs Tigers · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

PIT logo
PIT
PIT

4.36

--

--

--

DET logo
DET
DET

4.39

--

--

--

Cincinnati @ Toronto
Matchup Stats

Predicted Score

CIN logo
CIN
CIN

4.26 @ 4.53

TOR
TOR logo
TOR

Reds vs Blue Jays · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CIN logo
CIN
CIN

4.26

+135

o7.5 -130

+1.5 -160

TOR logo
TOR
TOR

4.53

-155

u8.0 -115

-1.5 +141

LA Dodgers @ San Francisco
Matchup Stats

Predicted Score

LAD logo
LAD
LAD

5.56 @ 2.65

SF
SF logo
SF

Dodgers vs Giants · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

LAD logo
LAD
LAD

5.56

-320

o7.5 +110

-1.5 -181

SF logo
SF
SF

2.65

+270

u7.5 -119

+1.5 +149

NY Mets @ Washington
Matchup Stats

Predicted Score

NYM logo
NYM
NYM

5.10 @ 4.65

WAS
WAS logo
WAS

Mets vs Nationals · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

NYM logo
NYM
NYM

5.10

-130

o8.5 +104

-1.5 +130

WAS logo
WAS
WAS

4.65

+116

u8.5 -114

+1.5 -143

Atlanta @ Miami
Matchup Stats

Predicted Score

ATL logo
ATL
ATL

5.07 @ 4.44

MIA
MIA logo
MIA

Braves vs Marlins · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

ATL logo
ATL
ATL

5.07

--

--

--

MIA logo
MIA
MIA

4.44

--

--

--

Texas @ Minnesota
Matchup Stats

Predicted Score

TEX logo
TEX
TEX

4.79 @ 4.06

MIN
MIN logo
MIN

Rangers vs Twins · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

TEX logo
TEX
TEX

4.79

--

--

--

MIN logo
MIN
MIN

4.06

--

--

--

Cleveland @ Kansas City
Matchup Stats

Predicted Score

CLE logo
CLE
CLE

4.55 @ 4.60

KC
KC logo
KC

Guardians vs Royals · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CLE logo
CLE
CLE

4.55

-129

o8.0 -115

-1.5 +130

KC logo
KC
KC

4.60

+110

u8.5 -125

+1.5 -155

Colorado @ Chi. White Sox
Matchup Stats

Predicted Score

COL logo
COL
COL

4.06 @ 4.85

CHW
CHW logo
CHW

Rockies vs White Sox · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

COL logo
COL
COL

4.06

+195

o7.5 -139

+1.5 -112

CHW logo
CHW
CHW

4.85

-230

u8.5 -130

-1.5 +100

St. Louis @ Milwaukee
Matchup Stats

Predicted Score

STL logo
STL
STL

3.88 @ 4.31

MIL
MIL logo
MIL

Cardinals vs Brewers · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

STL logo
STL
STL

3.88

+160

o7.5 -110

+1.5 -140

MIL logo
MIL
MIL

4.31

-188

u7.5 +100

-1.5 +121

Cleveland Guardians image thumbnail CLE @ Kansas City Royals image thumbnail KC Fri, Sep 25 • 7:40 PM ET
Total Home Runs
Jo Adell logo Jo Adell o0.5 Total Home Runs (+475)
Best Odds
Pick made: 9 hours ago
Todd Cordell logo
Todd Cordell
Betting Analyst

Jo Adell hits for a ton of power against southpaws. He is sporting a .265 ISO and 11.8% barrel rate vs. lefties, and those numbers rise even further when isolating Noah Cameron’s pitch mix.

Adell’s ISO sits at .285 facing fastballs, changeups, and cutters, which are the three pitches Cameron throws at least 20% of the time against RHH.

His bat speed vs. that combination is also tops on the Guardians.

Total
Cleveland Guardians image thumbnail Kansas City Royals image thumbnail u7.5 (-125)
Best Odds
Pick made: 9 hours ago
Todd Cordell logo
Todd Cordell
Betting Analyst

I am taking the Under to 56%.

Scoring against Gavin Williams is challenging enough, and it won’t get much easier when he exits the game. The Kansas City Royals will have to contend with the league’s best bullpen by wOBA in September.

The Cleveland Guardians are in poor form against left-handed pitching, hitting .228 with a measly 3.8% barrel rate this month.

View 15 Picks
Colorado Rockies image thumbnail COL @ Chicago White Sox image thumbnail CHW Fri, Sep 25 • 7:40 PM ET
Moneyline
Chicago White Sox image thumbnail CHW (-223)
Best Odds
Pick made: 10 hours ago
Quinn Allen logo
Quinn Allen
Betting Analyst

Sean Burke gives Chicago a significant edge on the mound after posting a 0.82 ERA and 3.10 FIP across his last two appearances. Colorado counters with Tomoyuki Sugano, who owns a 5.10 FIP over his previous five starts and has continued to surrender plenty of hard contact. The White Sox are the stronger side.

Total Hits
Randal Grichuk logo
Randal Grichuk u0.5 Total Hits (+165)
Projection 0.87
Best Odds
Pick made: 5 minutes ago
EV Model Rating
Star rating: 3 out of 5
Randal Grichuk has primarily hit in the top-half of the lineup this year (73% of the time), but he is projected to hit 7th in the lineup in this matchup.. This year, Randal Grichuk has been pulled from the game early in 20% of his appearances when starting against northpaw.. This contest is expected to have the 2nd-best weather for pitching among all the games scheduled today.. Tomoyuki Sugano will have the benefit of the platoon advantage against Randal Grichuk today.. Randal Grichuk has struggled with his Barrel% of late; his 10.5% seasonal rate has dropped off to 0% over the last week.
View 11 Picks
St. Louis Cardinals image thumbnail STL @ Milwaukee Brewers image thumbnail MIL Fri, Sep 25 • 7:40 PM ET
Moneyline
Milwaukee Brewers image thumbnail MIL (-179)
Best Odds
Pick made: 10 hours ago
Quinn Allen logo
Quinn Allen
Betting Analyst

Neither starter enters in dominant form, but Robert Gasser has been much better at keeping opposing hitters from doing serious damage. He's held opponents below a 30% hard-hit rate over his last two starts and has surrendered just 0.91 HR/9 at home this season. That gives Milwaukee the edge over Michael McGreevy and St. Louis.

Total RBIs
Jake Bauers logo
Jake Bauers o0.5 Total RBIs (+170)
Projection 0.59
Best Odds
Pick made: 5 minutes ago
EV Model Rating
Star rating: 3 out of 5
When assessing his overall offensive skill, Jake Bauers ranks in the 91st percentile according to the leading projections (THE BAT X).. Jake Bauers is penciled in 4th in the batting order in this matchup.. The leading projection system (THE BAT) profiles American Family Field as the 8th-best ballpark in Major League Baseball for LHB base hits.. Among all parks, American Family Field's centerfield dimensions are the 7th-shallowest.. American Family Field has the 4th-shortest fence height (on average) in Major League Baseball.
View 9 Picks
Texas Rangers image thumbnail TEX @ Minnesota Twins image thumbnail MIN Fri, Sep 25 • 8:10 PM ET
Total
Texas Rangers image thumbnail Minnesota Twins image thumbnail o7.0 (-120)
Best Odds
Pick made: 10 hours ago
Joe Osborne logo
Joe Osborne
Senior Betting Analyst

The Rangers have gone Over in five of their last six games, and this pitching matchup could make it six of seven. Jacob deGrom has been getting lit up on the road all season where he has a 5.35 ERA. Joe Ryan has been awful since the All-Star break, allowing 11 homers with a 7.62 ERA in six appearances. With both bullpens also struggling, seven runs looks too low.
 
 

Total Bases
Jake Burger logo
Jake Burger o1.5 Total Bases (+173)
Projection 1.51
Best Odds
Pick made: 11 minutes ago
EV Model Rating
Star rating: 3 out of 5
The leading projection system (THE BAT X) projects Jake Burger in the 96th percentile as it relates to his home run ability.. The leading projection system (THE BAT) profiles Target Field as the 9th-best ballpark in baseball for RHB batting average.. This game is projected to have the 3rd-most humid conditions on the slate today (77%); there is a small yet noteworthy connection with increased offense (and decreased whiffs) when the weather is humid.. The Minnesota Twins outfield defense profiles as the 4th-worst among every team playing today.. Jake Burger has made substantial improvements with his Barrel% recently, upping his 12.5% seasonal rate to 22.2% over the past week.
View 11 Picks
Houston Astros image thumbnail HOU @ Athletics Athletics image thumbnail ATH Fri, Sep 25 • 9:40 PM ET
Total Home Runs
Yordan Alvarez logo Yordan Alvarez o0.5 Total Home Runs (+271)
Best Odds
Pick made: 7 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

It must be the end of the season because we're getting Yordan Alvarez at one of his best prices in weeks, in maybe the best home-run matchup on the entire slate. Alvarez should be priced at 3.2x, not 3.7x, today against Jacob Lopez in Sacramento. Lopez looks like he wants to call it a season after giving up 10 runs in his last start and 19 runs over his last three starts, spanning just 12.1 innings. Lopez has also allowed multiple homers in three of his last four games, and Alvarez has taken him deep once in five meetings. This is the best September hitting weather, with winds blowing out, a tired starter who looks ready to wrap it up, and the price is right. Full send here.

Total Home Runs
Zack Gelof logo Zack Gelof o0.5 Total Home Runs (+710)
Best Odds
Pick made: 8 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

This was a run-not-walk trade at a fair price of 6x, not 8.1x. Zack Gelof just launched two homers last night in Sacramento and has five dingers over his last 10 games. He has 22 on the season and gets the best hitting conditions on the board today at Sutter Health Park, with winds blowing out and decent temperatures. Hunter Brown is on the other side, which is a big reason why this is priced this long, but Gelof has a .936 OPS at home compared to .664 on the road and has seen Brown 14 times. The numbers aren't great, but there is some familiarity there. Sutter Health Park can get to even the best pitchers, which is why it finished as the best Over park of the season at better than 60%.

View 15 Picks
Arizona Diamondbacks image thumbnail AZ @ San Diego Padres image thumbnail SD Fri, Sep 25 • 9:40 PM ET
Total Home Runs
Corbin Carroll logo Corbin Carroll o0.5 Total Home Runs (+400)
Best Odds
Pick made: 8 hours ago
Todd Cordell logo
Todd Cordell
Betting Analyst

Corbin Carroll hasn’t hit for average, but he’s generated barrels at a remarkably high 20.2% clip against fastballs, splitters, and sliders over the last 25 games. That has led to an ISO of nearly .240.

It’s also worth noting Carroll’s had Casey Mize’s number, albeit over a limited sample. He is 4-6 with four hard hit balls and a triple against Mize.

Total
Arizona Diamondbacks image thumbnail San Diego Padres image thumbnail o7.5 (-105)
Best Odds
Pick made: 9 hours ago
Todd Cordell logo
Todd Cordell
Betting Analyst

A 7.5 total is a touch low, and I’m jumping on the Over to 54%.

Case Mize has allowed 3.3 runs per start with the San Diego Padres despite failing to complete five innings on average. 

Brandon Pfaadt has not been sharp (4.63 ERA, 4.23 xERA) over the last month. That should be exposed by a Padres offense sitting Top-5 in wOBA and SLG against righties in September.

View 14 Picks
Los Angeles Angels image thumbnail LAA @ Seattle Mariners image thumbnail SEA Fri, Sep 25 • 10:10 PM ET
Strikeouts Thrown
Reid Detmers logo Reid Detmers o6.5 Strikeouts Thrown (-139)
Best Odds
Pick made: 10 hours ago
Quinn Allen logo
Quinn Allen
Betting Analyst

Detmers has been generating plenty of swings and misses lately, posting 9.60 K/9 over his last five appearances and clearing this number in three of his previous four. He also punched out eight Mariners just 10 days ago, and Seattle has averaged 8.71 strikeouts per game at home this season. Another strong strikeout performance is well within reach.

Total Bases
Josh Lowe logo
Josh Lowe o1.5 Total Bases (+260)
Projection 1.19
Best Odds
Pick made: 5 minutes ago
EV Model Rating
Star rating: 3 out of 5
Josh Lowe's BABIP skill is projected in the 77th percentile by the leading projection system (THE BAT X).. T-Mobile Park has the 8th-shortest average fence height among all major league stadiums.. The wind projects to be blowing out to LF at 15-mph in this contest, the most-favorable of the day for hitters.. Josh Lowe will hold the platoon advantage against Bryce Miller in today's game.. Josh Lowe has an 82nd percentile opposite-field rate on his flyballs (34.3%) and has the good fortune of hitting them in the direction of baseball's 9th-shallowest LF fences in today's matchup.
View 11 Picks
Los Angeles Dodgers image thumbnail LAD @ San Francisco Giants image thumbnail SF Fri, Sep 25 • 10:15 PM ET
Total Bases
Mookie Betts logo Mookie Betts o1.5 Total Bases (+103)
Best Odds
Pick made: 10 hours ago
Quinn Allen logo
Quinn Allen
Betting Analyst

Betts is seeing the ball exceptionally well, batting .458 over the last week with seven of his 11 hits going for extra bases. He's topped 1.5 total bases in five of his last seven games and now draws struggling rookie Yunior Marte along with a Giants bullpen carrying a 6.78 FIP over its last 22 innings. Betts should have plenty of opportunities to stay hot.

Total Home Runs
Max Muncy logo Max Muncy o0.5 Total Home Runs (+434)
Best Odds
Pick made: 10 hours ago
Ethan Diamandas logo
Ethan Diamandas
Betting Analyst

Play Max Muncy to 23% for a quarter unit. Muncy has 22 homers against right-handed pitching and matches up well with Marte’s four-seam-heavy arsenal.

View 14 Picks
Pittsburgh Pirates image thumbnail PIT @ Detroit Tigers image thumbnail DET Sat, Sep 26 • 1:10 PM ET
Moneyline
Detroit Tigers image thumbnail DET (-120)
Phil Naessens logo
Phil Naessens
Betting Analyst

Detroit sits at the top of baseball over the last 14 days with a 137 wRC+, pairing a .380 on-base percentage with a 3.53 bullpen SIERA. Justin Verlander takes the mound at Comerica Park for the final start of his Hall of Fame career. Facing a Pittsburgh bullpen carrying a 1.34 WHIP and 4.61 ERA, the Tigers hold massive offensive and bullpen advantages in an emotional home spot.

View Pick
Cleveland Guardians image thumbnail CLE @ Kansas City Royals image thumbnail KC Sat, Sep 26 • 7:10 PM ET
Moneyline
Cleveland Guardians image thumbnail CLE (-129)
Best Odds
Pick made: 2 hours ago
Phil Naessens logo
Phil Naessens
Betting Analyst

Cleveland enters the weekend in an all-out battle for the AL Central crown and the crucial first-round bye (No. 2 seed). Tanner Bibee gets the start, backed by a bullpen that ranks third in MLB over the last two weeks with a 2.99 SIERA and 31.3% strikeout rate. Kansas City's bullpen has faltered down the stretch (5.08 ERA, 1.47 WHIP), giving Cleveland a major late-inning edge with season-defining motivation.

View Pick
Arizona Diamondbacks image thumbnail AZ @ San Diego Padres image thumbnail SD Sat, Sep 26 • 8:40 PM ET
Moneyline
Arizona Diamondbacks image thumbnail AZ (+106)
Best Odds
Pick made: 2 hours ago
Phil Naessens logo
Phil Naessens
Betting Analyst

Arizona has rattled off five straight wins to stay alive in the wild-card race and gives the ball to Corbin Burnes in a must-win game. San Diego has already punched their postseason ticket, while the Diamondbacks offense has caught fire over the last fortnight (128 wRC+, .500 SLG, 3.49 bullpen SIERA). Getting Burnes backed by high urgency against Walker Buehler provides the premier late-game value on the board.

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What Is An MLB Computer Pick?

MLB picks are bet suggestions based on our computer's assessment of the game. Tons of betting data goes into a computer pick, including pitching matchups, injury reports, analytics, and even recent betting trends.

How To Use MLB Computer Picks

You can use the tables above to help with your bets during the MLB season. The first section includes free, computer-generated picks for daily Major League Baseball games. Baseball bettors can choose to follow the computer, fade the computer, or simply use our computer picks as one element of their betting strategy.

This page also tees up access to deeper betting trends. For example, if a club's run line is favored, you can check their ATS trends, potentially opening up some quality underdog bets.

If you're ready to get started with MLB betting, visit our dedicated page highlighting the best MLB betting sites.

Moneyline

This is the most common and easiest wager for a bettor to make when it comes to MLB picks. Basically, to win an MLB moneyline pick, you just have to choose which team will win the game.

It's simple: if you bet the White Sox moneyline over the Red Sox and Chicago wins, you win your bet.

Run line

The run line is another name for a point spread that you may be more familiar with in NBA and NFL betting. A point spread varies in the NFL and NBA from as little as 0.5 points up to double-digit spreads. A baseball run line is almost always a 1.5-point spread.

The favorite will be -1.5 while the underdog will be +1.5. At the end of the game, if you take away 1.5 runs from the favorite or add 1.5 runs to the underdog and they end up winning the game, you win your MLB pick against the spread.

Totals (Over/Under)

Another common wager is to bet on the total in baseball, which is a bet on the total runs scored in the baseball game. You are simply choosing whether the final score will be Over or Under that total. Betting the Over/Under on a matchup is a great way to get started in MLB score predictions.

Free Computer Picks by Odds Shark

More MLB Picks & Betting Tools

NRFI/YRFI MLB Picks

A new and emerging MLB betting market is the NRFI/YRFI bet. These are quick-hitters in which you make a wager on the O/U total of the first inning, typically set at 0.5 runs. Thus, the bet is coined as No Run First Inning or Yes Run First Inning. No need to wait a couple of hours to cash a bet when it could be done in 20 minutes or less.

First Five Innings MLB Picks

The above options, moneyline, run line, and Over/Under, can also be placed on the first five innings of a game rather than the full game. Many experienced bettors will use this approach because, typically, this will take bullpens out of the equation and make your job researching the game easier. After all, you can just focus on the starting pitchers.

MLB Picks And Parlays

If you want to combine multiple games into one mega wager, you may consider making a parlay bet. A parlay is when you pick two or more MLB games on one single betting ticket, which will increase the payout of your bet.

But it also comes with more risk, as each of those MLB picks must hit for your ticket to pay out. Our parlay calculator is a great tool to find out what your potential payout would be.

If you're looking for more MLB picks content, check out our consensus picks and prop bets pages to get your fix. While you're at it, head over to our MLB promos page to get the best bang for your buck.

MLB Player Props

Player props are a great way to hone in on an individual matchup for a game. These types of wagers will be individualized for a player: Will Shohei Ohtani hit a home run? Will Gerrit Cole get seven strikeouts? Will Paul Skenes allow two earned runs?

You simply choose whether this outcome will happen or not. Keeping up to date on daily pitching matchups and batters on a hot streak can give you a huge boost when placing player prop bets.

MLB Futures Picks

Lastly, prior to the season and even throughout the season, you can place futures bets on all the long-term awards and outcomes. You can lock in an MLB pick on who will win their division, which squad will win the World Series, or even who will win the Rookie of the Year, MVP, or Cy Young.

MLB Free Picks FAQs

When do we release our MLB picks?

Covers’ MLB picks release on game day. Some significant matchups like playoff games release in the days leading up to the game.

What kinds of MLB picks do we make?

Covers provides free MLB picks covering many markets, including run lines, totals, moneylines, player props, and more.