The Los Angeles Dodgers open their final road series of the regular season at Oracle Park tonight against a San Francisco club playing out the string at 65-94.
The Dodgers sit at a 77% implied probability on the moneyline, with first pitch set for 10:15 p.m. ET.
Tarik Skubal’s final regular-season start shapes my Dodgers vs. Giants predictions, which are anchored by the Los Angeles run line.
Read more in my MLB picks for Friday, Sept. 25.
Who will win Dodgers vs Giants today: Dodgers -2.5
For help understanding probabilities, see our odds calculator.
I’d play this to 54%.
The Los Angeles Dodgers are a massive favorite, and I’d rather take the aggressive run line than pay 77% simply for the Dodgers to win.
Tarik Skubal brings a 2.85 ERA, a 0.99 WHIP, and 176 strikeouts against a rookie in Yunior Marte, who owns a 4.66 ERA and a 1.40 WHIP in a thin major-league sample.
The form gap is just as wide. Los Angeles is 7-3 over its last 10 games with a plus-24 run differential, while the San Francisco Giants are 3-7 and hitting .228 without several key bats.
The Dodgers swept the previous series 8-2, 10-4, and 3-1, covering 2.5 runs twice.
COVERS INTEL: Marte faced this Los Angeles lineup last Friday and allowed six runs in 4 2/3 innings, surrendering at least one run in every inning he worked.
Dodgers vs Giants Over/Under pick: Under 7.5
The Giants’ matchup with Skubal makes Under 7.5 my preferred total play up to 55%.
Skubal’s strikeouts and limited traffic leave a depleted San Francisco lineup almost nothing to work with. His 0.99 WHIP keeps runners off base against an offense hitting .228 over its last 10 games.
Oracle Park helps as well, ranking among baseball's tougher run environments.
The clearest path has Los Angeles doing the most scoring while Skubal keeps San Francisco quiet. I see this landing closer to 5-1 or 6-1.
Dodgers vs Giants home run prediction: Max Muncy
Max Muncy gives us the Dodgers' best power at a fair number, up to 23%.
Muncy has hit 29 home runs this season, 22 of them against right-handed pitching, without the premium attached to Shohei Ohtani.
Marte’s pitch mix is the opening. The rookie throws his four-seam fastball and slider nearly 90% of the time, and hitters have squared up both.
The four-seamer is the cleaner matchup. Muncy has slugged .612 against four-seamers this season with a 51.2% hard-hit rate.
- ML/RL picks: 5-11, -6.73 units
- Over/Under picks: 10-6 +3.34 units
Dodgers vs Giants weather
Cool, damp marine air rolls into Oracle Park for the late start, conditions that consistently hold down fly balls in San Francisco.
Dodgers vs Giants odds
- Moneyline: Dodgers 77% | Giants 24%
- Run line: Dodgers -2.5 | Giants +2.5
- Over/Under: Over 7.5 | Under 7.5
Dodgers vs Giants trend
The Dodgers have won and covered a 2.5-run line in two of their last three meetings with San Francisco. Find more MLB betting trends for Dodgers vs. Giants.
How to watch Dodgers vs Giants and game info
| Location | Oracle Park, San Francisco, CA |
| Date | Friday, September 25, 2026 |
| First pitch | 10:15 p.m. ET |
| TV | SNLA, NBC Sports Bay Area |
| Dodgers starting pitcher | Tarik Skubal (11-7, 2.85 ERA) |
| Giants starting pitcher | Yunior Marte (0-1, 4.66 ERA) |
Dodgers vs Giants latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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