It's the penultimate week on the regular-season calendar, and we get a Thursday tripleheader for Christmas Day as a holiday treat.
The Dallas Cowboys open proceedings at the Washington Commanders as 5.5-point road favorites before the Detroit Lions travel to Minneapolis to face the Minnesota Vikings (+5.5).
Thursday Night Football on Christmas Day sure looked like a marquee matchup before the season started, but the Patrick Mahomes-less Kansas City Chiefs are 11.5-point home underdogs to the Denver Broncos.
There are some big-time clashes on the weekend, though, with the Houston Texans and Los Angeles Chargers (+1.5) meeting on Saturday and the Philadelphia Eagles at Buffalo Bills (-2.5) and Chicago Bears at San Francisco 49ers (-2.5) headline Sunday's action.
Let's look at all the Week 17 odds as Week 16 winds down.
NFL odds Week 17
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 Cowboys@  Commanders |
Commanders +5.5 | Cowboys -295 Commanders +240 |
49.5 |
 Lions@  Vikings |
Vikings +5.5 | Lions -270 Vikings +220 |
45.5 |
 Broncos@  Chiefs |
Chiefs +11.5 | Broncos -900 Chiefs +610 |
36.5 |
 Texans@  Chargers |
Chargers +1.5 | Texans -110 Chargers +106 |
40.5 |
 Ravens@  Packers |
Packers +1.5 | Ravens -116 Packers -102 |
43.5 |
 Cardinals@  Bengals |
Bengals -6.5 | Cardinals +260 Bengals -320 |
52.5 |
 Seahawks@  Panthers |
Panthers +7.5 | Seahawks -360 Panthers +290 |
42.5 |
 Jaguars@  Colts |
Colts +6.5 | Jaguars -340 Colts +275 |
45.5 |
 Patriots@  Jets |
Jets +12.5 | Patriots -1000 Jets +660 |
41.5 |
 Steelers@  Browns |
Browns +5.5 | Steelers -250 Browns +205 |
35.5 |
 Saints@  Titans |
Titans +3 | Saints -158 Titans +134 |
38.5 |
 Buccaneers@  Dolphins |
Dolphins +4.5 | Buccaneers -240 Dolphins +198 |
46.5 |
 Giants@  Raiders |
Raiders +2.5 | Giants -134 Raiders +114 |
42.5 |
 Eagles@  Bills |
Bills -2.5 | Eagles +126 Bills -148 |
45.5 |
 Bears@  49ers |
49ers -2.5 | Bears +122 49ers -144 |
50.5 |
 Rams@  Falcons |
Falcons +8.5 | Rams +620 Falcons +460 |
49.5 |
Lines as of 12-21
Enjoying Covers content? Add us as a preferred source on your Google account
Cowboys vs Commanders odds (Thursday, 1:00 p.m. ET, Netflix)
Opening line
- Commanders +3.5
- Over/Under 51.5
- View full Cowboys vs. Commanders odds and matchup
- Read our Cowboys vs. Commanders picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Thursday Night Football odds
Lions vs Vikings odds (Thursday, 4:30 p.m. ET, Netflix)
Opening line
- Vikings +3.5
- Over/Under 48.5
- View full Lions vs. Vikings odds and matchup
- Read our Lions vs. Vikings picks and predictions (coming soon)
Opening line analysis coming soon!
Broncos vs Chiefs odds (Thursday, 8:15 p.m. ET, Prime Video)
Opening line
- Chiefs +5.5
- Over/Under 40.5
- View full Broncos vs. Chiefs odds and matchup
- Read our Broncos vs. Chiefs picks and predictions (coming soon)
Opening line analysis coming soon!
Covers NFL betting tools
- NFL odds
- NFL picks
- NFL player props
- Super Bowl 60 odds
- Best NFL betting sites
- This week’s NFL matchups
Texans vs Chargers odds (Saturday, 4:30 p.m. ET, NFL Network)
Opening line
- Chargers +1.5
- Over/Under 39.5
- View full Texans vs. Chargers odds and matchup
- Read our Texans vs. Chargers picks and predictions (coming soon)
Opening line analysis coming soon!
Ravens vs Packers odds (Saturday, 8:00 p.m. ET, Peacock)
Opening line
- Packers -3
- Over/Under 45.5
- View full Ravens vs. Packers odds and matchup
- Read our Ravens vs. Packers picks and predictions (coming soon)
Opening line analysis coming soon!
Cardinals vs Bengals odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Bengals -5.5
- Over/Under 50.5
- View full Cardinals vs. Bengals odds and matchup
- Read our Cardinals vs. Bengals picks and predictions (coming soon)
Opening line analysis coming soon!
Covers NFL awards analysis
Seahawks vs Panthers odds(Sunday, 1:00 p.m. ET, CBS)
Opening line
- Panthers +7.5
- Over/Under 42.5
- View full Seahawks vs. Panthers odds and matchup
- Read our Seahawks vs. Panthers picks and predictions (coming soon)
Opening line analysis coming soon!
Jaguars vs Colts odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Colts +4.5
- Over/Under 44.5
- View full Jaguars vs. Colts odds and matchup
- Read our Jaguars vs. Colts picks and predictions (coming soon)
Opening line analysis coming soon!
Patriots vs Jets odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Jets +9.5
- Over/Under 42.5
- View full Patriots vs. Jets odds and matchup
- Read our Patriots vs. Jets picks and predictions (coming soon)
Opening line analysis coming soon!
More NFL betting analysis
- Aaron Rodgers’ record vs. every NFL team
- Patrick Mahomes’ record vs. every NFL team
- Russell Wilson’s record vs. every NFL team
- Josh Allen’s record vs. every NFL team
- Lamar Jackson’s record vs. every NFL team
Steelers vs Browns odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Browns +4.5
- Over/Under 34.5
- View full Steelers vs. Browns odds and matchup
- Read our Steelers vs. Browns picks and predictions (coming soon)
Opening line analysis coming soon!
Saints vs Titans odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Titans +2.5
- Over/Under 39.5
- View full Saints vs. Titans odds and matchup
- Read our Saints vs. Titans picks and predictions (coming soon)
Opening line analysis coming soon!
Buccaneers vs Dolphins odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Dolphins +2.5
- Over/Under 46.5
- View full Buccaneers vs. Dolphins odds and matchup
- Read our Buccaneers vs. Dolphins picks and predictions (coming soon)
Opening line analysis coming soon!
Giants vs Raiders odds (Sunday, 4:05 p.m. ET, CBS)
Opening line
- Raiders +3
- Over/Under 42.5
- View full Giants vs. Raiders odds and matchup
- Read our Giants vs. Raiders picks and predictions (coming soon)
Opening line analysis coming soon!
Eagles vs Bills odds (Sunday, 4:25 p.m. ET, FOX)
Opening line
- Bills -3
- Over/Under 44.5
- View full Eagles vs. Bills odds and matchup
- Read our Eagles vs. Bills picks and predictions (coming soon)
Opening line analysis coming soon!
Bears vs 49ers odds (Sunday, 8:20 p.m. ET, NBC)
Opening line
- 49ers -2.5
- Over/Under 51.5
- View full Bears vs. 49ers odds and matchup
- Read our Bears vs. 49ers picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Sunday Night Football odds
Rams vs Falcons odds (Monday, 8:15 p.m. ET, ESPN)
Opening line
- Falcons +8.5
- Over/Under 48.5
- View full Rams vs. Falcons odds and matchup
- Read our Rams vs. Falcons picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Monday Night Football odds
Best NFL bets this week
Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
