The NFL is back, baby. The 2025 season kicks off with blockbuster matchups, bitter rivalries, and fresh storylines that will define the long and grueling year ahead.
Instead of leaving the picks to the talking heads, we turned to artificial intelligence instead. Using the Week 1 moneyline odds from FanDuel, we asked ChatGPT to pick the straight-up winners of every single game on the schedule from the opening whistle on Thursday night to the final play on Monday.
Here’s how the AI sees Week 1 shaking out with its NFL picks.
Week 1 NFL moneyline picks
| Matchup | Pick |
|---|---|
 Cowboys vs  Eagles |
-430 |
 Chiefs vs  Chargers |
-168 |
 Buccaneers vs  Falcons |
-130 |
 Steelers vs  Jets |
-146 |
 Dolphins vs  Colts |
-110 |
 Panthers vs  Jaguars |
-190 |
 Giants vs  Commanders |
-190 |
 Cardinals vs  Saints |
-290 |
 Bengals vs  Browns |
-235 |
 Raiders vs  Patriots |
-142 |
 49ers vs  Seahawks |
-132 |
 Titans vs  Broncos |
-430 |
 Lions vs  Packers |
-134 |
 Texans vs  Rams |
-156 |
 Ravens vs  Bills |
-108 |
 Vikings vs  Bears |
-112 |
Lines courtesy of FanDuel as of 9-4.
Week 1 NFL moneyline picks
Cowboys vs. Eagles: Eagles (-430)
The Philadelphia Eagles enter the season with Super Bowl expectations, and FanDuel odds reflect it, making them heavy favorites over Dallas. Philadelphia’s loaded offensive line, Jalen Hurts’ dual-threat ability, and a defense built to pressure Dak Prescott create a nightmare scenario for the Cowboys. Dallas still has plenty of talent on both sides of the ball, but Philly at home in prime time feels like too tall an order.
Chiefs vs. Chargers: Chiefs (-168)
Patrick Mahomes rarely starts slow, and the Kansas City Chiefs have history on their side against the Chargers. L.A. has the firepower to keep it close, but questions remain around their defensive consistency. The Chiefs’ offense has a way of finding rhythm early in the season, and their defense, which took a big step forward last year, should keep Justin Herbert in check just enough.
Buccaneers vs. Falcons: Buccaneers (-130)
NFC South games rarely follow a script, but the Tampa Bay Buccaneers are favored and bring a defense that should disrupt Atlanta’s young offense. Tampa Bay’s offense has questions, but its veteran leadership and ability to limit mistakes could carry them over a Falcons team still searching for an identity.
Steelers vs. Jets: Steelers (-146)
This is a sneaky-good matchup. The Jets bring defensive punch and home-field energy, but the Pittsburgh Steelers are slight favorites thanks to a balanced roster and consistency at head coach. Pittsburgh’s pass rush could give the Jets’ offensive line problems, and in a game that figures to be low-scoring, turnovers could tip the scales. Trust Mike Tomlin’s group in Week 1.
Dolphins vs. Colts: Colts (-110)
This is as close to a pick ’em as you’ll see on the Week 1 board. The Dolphins have speed, but the Indianapolis Colts’ slight edge at home and balanced approach nudges them into favorite status. Expect a tight game where late-game execution will matter most. FanDuel odds show just how razor-thin this margin is.
Panthers vs. Jaguars: Jaguars (-190)
The Jacksonville Jaguars are poised to push for AFC South supremacy again, and Week 1 gives them a favorable draw. Carolina continues to develop its young core, but Jacksonville’s offensive weapons and Trevor Lawrence’s command give them the advantage. The Panthers’ defense can keep them in it for stretches, yet the Jaguars’ ability to finish drives should prove decisive.
Giants vs. Commanders: Commanders (-270)
The Giants have made improvements, but FanDuel lists them as big underdogs on the road. The Washington Commanders’ defense remains its calling card, and with an efficient offense behind a solid ground game, the Commanders are built to handle divisional rivals at home. The Giants will need a big game from their passing attack to stay competitive, but the edge lies with Washington.
Cardinals vs. Saints: Cardinals (-290)
The Arizona Cardinals are one of the heaviest favorites on the board, and for good reason. Their explosive offense makes them tough to keep up with, especially in their own stadium. The Saints’ defense is gritty, but unless their offense can sustain drives, it may be tough to match points with Kyler Murray and company.
Bengals vs. Browns: Bengals (-235)
The Battle of Ohio kicks off with the Cincinnati Bengals as solid favorites. Joe Burrow’s track record against Cleveland isn’t spotless, but Cincinnati’s firepower gives them the upper hand. The Browns have the talent to challenge, but their inconsistency has bettors leaning Bengals. This could be one of the AFC’s most telling Week 1 results.
Raiders vs. Patriots: Patriots (-142)
The New England Patriots enter as small favorites, and their physical defense should dictate tempo against the Raiders. Las Vegas will try to stretch the field, but if New England controls the ground game and limits explosive plays, they’ll grind out the win. Home-field advantage and coaching discipline help tilt this matchup their way.
49ers vs. Seahawks: 49ers (-132)
An NFC West classic to open the season. The San Francisco 49ers are slight favorites, and their physicality up front on both sides of the ball gives them the edge. Seattle has the weapons to strike back, but San Francisco’s balance and defensive pressure should be the difference. This one could be tight to the end.
Titans vs. Broncos: Broncos (-430)
The Denver Broncos are one of Week 1’s biggest favorites. Playing at altitude early in the year is always tough, and the Titans may struggle to keep pace. The Broncos’ defense is capable of smothering opponents, and their offense should do enough to separate by the second half.
Lions vs. Packers: Packers (-134)
In another divisional slugfest, the Green Bay Packers are small favorites at Lambeau. Detroit’s ascending roster will test Green Bay, but home-field advantage and a proven defensive front lean the odds toward the Packers. Expect intensity in a game that could foreshadow the NFC North race.
Texans vs. Rams: Rams (-156)
The Los Angeles Rams enter Week 1 with moderate favorite status, and their high-powered passing game will be tested against Houston’s young defense. The Texans are building momentum, but in Los Angeles, Matthew Stafford and his weapons give the Rams the inside track.
Ravens vs. Bills: Bills (-108)
FanDuel has this one dead even, and it’s easy to see why. Both teams boast elite quarterbacks and aggressive defenses. The Buffalo Bills’ home-field advantage and ability to generate explosive plays through Josh Allen give them the tiniest edge. Expect a heavyweight fight worthy of Sunday night.
Vikings vs. Bears: Vikings (-112)
Week 1 closes with a near toss-up in Chicago. Both teams have high hopes in the NFC North, but the Minnesota Vikings’ odds give them a slight advantage. Minnesota’s offensive balance and knack for winning close games could prove decisive. Chicago will fight, but the margin here is as thin as it gets.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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