The Kansas City Chiefs are in full-on desperation mode as they host the Los Angeles Chargers in Week 15.
Kansas City must win out to keep its playoff hopes alive at 6-7, while Los Angeles is a 5.5-point underdog despite having the better record (9-4).
See why I’m betting on a lower-scoring game with my Chargers vs. Chiefs predictions and NFL picks for Sunday, December 14.
Chargers vs Chiefs prediction
Chargers vs Chiefs Best bet: Under 41.5 (-110)
Both squads are dealing with injury concerns, and that could lead to a lower-scoring game in Week 15.
The Kansas City Chiefs' offensive line is in shambles, with right tackle Jawaan Taylor and Wanya Morris both considered long shots to play, and right guard Trey Smith downgraded to a limited participant on Thursday.
The offense mustered just 274 total yards last week against Houston due to the litany of offensive line injuries, and the situation isn’t much better now.
The Los Angeles Chargers have concerns in the passing game as quarterback Justin Herbert plays through a broken hand, and star wideout Ladd McConkey is limited in practice with a foot injury.
It’s not a coincidence that the offense had only 275 total yards against the Eagles in Week 14, and a hobbled Herbert will be hard-pressed to have a successful day against Kansas City’s stout defense.
It’ll be a cold day at Arrowhead with temperatures ranging from 14-20 degrees throughout the contest. The Chiefs have been an Under team all year at 4-9 O/U, and will now feature in a game where both offenses have injury concerns and will be playing in frigid weather.
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Chargers vs Chiefs same-game parlay
The Chargers have been miserable on the road (1-4 ATS), getting trounced by the Jaguars (6-35) and losing to the Giants while notching wins over unimpressive opponents only (Raiders, Dolphins, Titans).
Put another way, they’ve yet to beat a team of any worth on the road this season, and now face a desperate Chiefs team in a game where Herbet is playing with a broken hand.
Rashee Rice has racked up at least 80 receiving yards in four of his last six games while averaging 79.7 in that span, so his receiving yardage prop of 63.5 is too low.
Chargers vs Chiefs 3-leg SGP
- Under 41.5
- Chiefs -5.5
- Rashee Rice Over 63.5 receiving yards
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Our big-ticket SGP: Rice, Rice, baby
It’s been a while since we’ve seen the typical fourth-quarter voodoo that Patrick Mahomes works in comeback victories. What better time for Mahomes to win a second half than at home with his team’s playoff hopes on the line?
Chargers vs Chiefs 5-leg SGP
- Under 41.5
- Chiefs -5.5
- Rashee Rice Over 63.5 receiving yards
- Rashee Rice Over 6.5 receptions
- Chiefs -2.5 2H
Chargers vs Chiefs odds
- Spread: Chargers +5.5 | Chiefs -5.5
- Moneyline: Chargers +215 | Chiefs -260
- Over/Under: Over 41.5 | Under 41.5
More NFL picks and odds from Covers
Chargers vs Chiefs trend to know
The Chiefs have gone Under the total in seven of their last eight games. Find more NFL betting trends for Chargers vs. Chiefs.
How to watch Chargers vs Chiefs
| Location | GEHA Field at Arrowhead Stadium, Kansas City, MO |
| Date | Sunday, December 14, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | CBS |
Chargers vs Chiefs latest injuries
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