The 5-3 San Francisco 49ers head to MetLife Stadium to face the reeling New York Giants on Sunday, November 2.
My top NFL picks and 49ers vs. Giants predictions are calling for San Fran to take care of business and cover the number against the swiss cheese New York defense in Week 9.
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49ers vs Giants prediction
49ers vs Giants Best bet: 49ers -2.5 (-115)
One of the easiest fades in the NFL is betting against teams that can’t stop the run.
The New York Giants have been gashed on the ground to the tune of NFL highs in both yards and EPA per rushing attempt, and I’m confident that if the G-Men sell out to improve their run defense, the San Francisco 49ers can move the ball through the air.
Either way, I’m anticipating the 49ers controlling the time of possession and covering the number Sunday afternoon at MetLife Stadium.
And, while the Niners definitely have shortcomings, their offense ranks 10th in DVOA and 11th in PFF grade while averaging the eighth longest drives. I also value San Fran heading east with the third-highest third-down conversion rate.
Again, it’s a bad recipe for a New York defense that can’t stop the run.
49ers vs Giants same-game parlay
Niners tight end George Kittle found the end zone last week, and the Giants have surrendered three touchdowns to the position across their past three games. I expect Kittle’s role in the passing attack to amp up now that he’s back in action and multiple games removed from his hamstring injury.
The final leg of this same-game parlay turns to New York wide receiver Wan'Dale Robinson who’s defacto No. 1 option in the passing game. He hauled in 12 of 19 targets for 179 yards in Weeks 6 and 7 before being held to 48 yards on three receptions and four targets last time out.
Look for Robinson to clear this benchmark with the Giants trailing and going to the aerial attack late in Sunday’s game.
49ers vs Giants SGP
- 49ers -2.5
- George Kittle anytime touchdown
- Wan'Dale Robinson Over 51.5 receiving yards
Our big-ticket SGP: Giants can't stop the faucet
The Giants have allowed a whopping 71 points the past two weeks, and played to the Over in six of their past 10 home games.
49ers vs Giants SGP
- 49ers -2.5
- Over 48.5
- George Kittle anytime touchdown
- Wan'Dale Robinson Over 51.5 receiving yards
49ers vs Giants odds
- Spread: 49ers -2.5 (-115) | Giants +2.5 (-105)
- Moneyline: 49ers -148 | Giants +126
- Over/Under: Over 48.5 (-105) | Under 48.5 (-115)
More NFL picks and odds from Covers
49ers vs Giants trend to know
The New York Giants have hit the game total Over in 6 of their last 10 games at home (+1.60 Units / 15% ROI). Find more NFL betting trends for 49ers vs. Giants.
How to watch 49ers vs Giants
| Location | MetLife Stadium, East Rutherford, NJ |
| Date | Sunday, November 2, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | CBS |
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