An SEC battle awaits us when South Carolina travels to LSU.
After a bye week, the Tigers will be eager to wipe the bad taste out of their mouths that came when Ole Miss handed them their first loss of the season. Meanwhile, it’ll be South Carolina looking to get a major marquee win.
My South Carolina vs. LSU predictions break it all down as I bring you my college football picks for Saturday, October 11.
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South Carolina vs LSU prediction
South Carolina vs LSU best bet: LSU -9.5 (-106 at FanDuel)
Allow me to be blunt, this South Carolina Gamecocks offense isn’t good. Well at least it hasn’t shown if it is. QB Lanorris Sellers being banged up at times has been considered but even still the numbers this unit has put up are pretty ugly.
Don’t believe me? Take a look for yourself. The Gamecocks rank:
- 75th in EPA per dropback
- 88th in yards per play
- 114th in EPA per rush
- 130th in average third down distance
Ultimately, these all combine together to be the decisive factor that makes LSU -9.5 my best bet, I’m projecting right at two points of value against the Vegas line.
This LSU Tigers offense hasn’t been great but it’s certainly shown more competence than the other side. The loss at Ole Miss raised questions, sure but you still have a nice set of data that supports the theory that this is a plus group.
As you’d expect, the offense has been its best through the air behind QB Garrett Nussmeier ranking just inside the top 50 nationally in EPA per dropback.
While it hasn’t been the most explosive group, it’s been efficient at staying on schedule with strong intermediate games ranking also inside the top 50 in yards per play.
Sometimes it’s more complicated and sometimes it isn’t. I think this is how LSU gets the win and cover. South Carolina just hasn’t shown the ability to string multiple efficient offensive drives together and LSU has.
Expecting that to change in a hostile Tiger Stadium with the Tigers looking to bounce back from a loss seems to be wishful thinking at best.
South Carolina vs LSU same-game parlay
Two strong defenses should be reasonably well prepared for these offenses and consequently I expect the game to start out slow before opening up later.
With that in mind, I took the 1st Quarter under 9.5. I paired it with Bauer Sharp to find the end zone who looks to be the player to profit most from intermediate openings in the USC defense.
South Carolina vs LSU SGP
- LSU -9.5
- 1Q Under 9.5
- Bauer Sharp anytime touchdown
Our deep-ball SGP: Fade Brown, Sellers
For the longshot parlay we took a few others.
I don’t expect the explosive Barion Brown to get a ton of volume here simply because the South Carolina offense doesn’t allow a ton of explosive plays, especially through the air.
I faded him here along with LaNorris Sellers on the ground who holds a huge sack risk against a strong havoc generating defense.
South Carolina vs LSU SGP
- LSU -9.5
- 1Q Under 9.5
- Bauer Sharp anytime touchdown
- Barion Brown Under 47.5 receiving yards
- LaNorris Sellers Under 29.5 rushing yards
South Carolina vs LSU odds
- Spread: South Carolina +8.5 (-110) | LSU -8.5 (-110)
- Moneyline: South Carolina +270 | LSU -335
- Over/Under: Over 44.5 (-105) | Under 44.5 (-115)
South Carolina vs LSU trend to know
South Carolina have covered the Spread in 9 of their last 13 games (+4.60 Units / 32% ROI). Find more college football betting trends for South Carolina vs LSU.
How to watch South Carolina vs LSU
| Location | Tiger Stadium, Baton Rouge, LA |
| Date | Saturday, October 11, 2025 |
| Kickoff | 7:45 p.m. ET |
| TV | SEC Network |
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