The Week 7 college football slate is headlined by the Red River Rivalry and a Big Ten battle between Indiana and Oregon in Eugene.
I use my ATS college football picks below to pick a side in all of Week 7's biggest matchups.
College football picks against the spread for Week 7
| Matchup | Pick |
|---|---|
 South Florida vs  North Texas |
(-1.5) |
 Ohio State vs  Illinois |
(-14.5) |
 Alabama vs  Missouri |
(-3.5) |
 Oklahoma vs  Texas |
(+2.5) |
 Indiana vs  Oregon |
(-7.5) |
 Florida vs  Texas A&M |
(+7.5) |
 Kansas vs  Texas Tech |
(-13.5) |
 Georgia vs  Auburn |
(+3.5) |
 Michigan vs  USC |
(+2.5) |
 South Carolina vs  LSU |
(+8.5) |
 BYU vs  Arizona |
(+1.5) |
Lines courtesy of FanDuel.
Expert Week 7 CFB ATS picks
South Florida (-1.5) vs North Texas: South Florida -1.5
This spread opened as high as UNT -2.5 and has already crossed the fence to USF -1.5. There's nothing in UNT's resume to suggest the Mean Green should have been favored in the first place, so I'm siding with the movement.
Ohio State (-14.5) vs Illinois: Ohio State -14.5
Covering spreads has come easy for Ohio State thus far, doing so in four of five games and covering by an average margin of 13.1 points in those four covers. More of the same is coming in Champaign.
Read our full Ohio State vs. Illinois predictions.
Alabama (-3.5) vs Missouri: Alabama -3.5
Alabama has come a very long way since losing to FSU, and while Missouri remains undefeated, I don't see the Tide slipping up.
Read our full Alabama vs. Missouri predictions.
Oklahoma vs Texas (-2.5): Oklahoma +2.5
The latest news suggests Oklahoma quarterback John Mateer could be returning this week. That gives the Sooners the edge against a preseason No. 1 Texas squad that's suddenly staring 3-3 in the face.
Read our full Oklahoma vs. Texas predictions.
Indiana vs Oregon (-7.5): Oregon -7.5
For as good as Indiana has looked at times this season, there's still a gap between the Hoosiers and the Big Ten's elite programs. That will manifest itself in Eugene this weekend.
Read our full Indiana vs. Oregon predictions.
Florida vs Texas A&M (-7.5): Florida +7.5
It took more than three quarters for Texas A&M to put Mississippi State away last week, and it certainly feels like a vintage slip-up is coming.
Read our full Florida vs. Texas A&M predictions.
Kansas vs Texas Tech (-13.5): Texas Tech -13.5
In back-to-back road wins over Utah and Houston, Texas Tech averaged 34.5 points per game on offense and gave up 10.5 on defense. Those muscles will get flexed ever harder at home.
Read our full Kansas vs. Texas Tech predictions.
Georgia (-3.5) vs Auburn: Auburn +3.5
Don't let a 3-2 record that includes two tight road losses fool you; Auburn is a good football team. Georgia has been far from perfect, and I expect a close game in front of a raucous Jordan-Hare.
Read our full Georgia vs. Auburn predictions.
Michigan vs USC (-2.5): Michigan +2.5
Michigan outgained Wisconsin by nearly 200 yards in a pedestrian 24-10 win and averaged 7.2 yards per play. Illinois made USC look inferior, and the signs point to a second loss this week.
Read our full Michigan vs. USC predictions.
South Carolina vs LSU (-8.5): South Carolina +8.5
LSU's offense being in such flux makes it incredibly hard for me to imagine a double-digit victory here. The Tigers are 1-3 ATS since beating Clemson, while South Carolina has covered in two straight.
Read our full South Carolina vs. LSU predictions.
BYU (-1.5) vs Arizona: Arizona +1.5
This is a BYU team that had to come back to win by three as a 6.5-point favorite at Colorado. Give me Noah Fifita and the Wildcats at home in a close one.
Read our full BYU vs. Arizona predictions.
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My college football ATS/ML record is 23-29 this season for -7.45 units.
Odds are correct at the time of publishing and are subject to change.
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