The Chicago White Sox head to the Bay Area tonight to begin a three-game series with the San Francisco Giants. First pitch is scheduled for 10:15 p.m. ET at Oracle Park.
With an intriguing pitching matchup, my White Sox vs. Giants predictions see value in the Under.
Read more in my MLB picks for Friday, May 22.
Who will win White Sox vs Giants today: White Sox moneyline (-108)
The Chicago White Sox send their ace to the mound tonight in Davis Martin. He's dominated this year, compiling a 1.61 ERA and 6-1 record through nine starts.
Martin has also been solid on the road, sporting a 1.95 ERA. He's up against a San Francisco Giants team that is 30th in runs scored and has lost three straight.
Chicago has also won three of the last four meetings against the Giants. The hosts hand Trevor McDonald the ball, and he's allowed six earned runs at home across his last two outings.
COVERS INTEL: The Giants are 20th in wRC+ in May, sitting at 92. 
White Sox vs Giants Over/Under pick: Under 7.5 (-125)
While McDonald hasn't been at his best at Oracle Park lately, he does have a very respectable 2.37 ERA overall through three starts.
The right-hander has shown the ability to get outs on a consistent basis, and the White Sox aren't exactly thriving at the dish lately, scoring just six runs across their previous series with the Mariners.
Martin, meanwhile, can't do much wrong, giving up two earned runs or fewer ever since his season debut on March 30.
He is lights-out, and the Giants have struggled immensely all year to muster up any offense. Also, four of the last five meetings have hit the Under.
- ML/RL bets: 15-11, +4.72 units
- Over/Under bets: 15-11, +2.09 units
White Sox vs Giants odds
- Moneyline: White Sox -104 | Giants -100
- Run line: White Sox -1.5 (+148) | Giants +1.5 (-192)
- Over/Under: Over 7.5 (-101) | Under 7.5 (-127)
White Sox vs Giants trend
The White Sox have hit the moneyline in 19 of their last 30 games (+10.25 Units / 33% ROI). Find more MLB betting trends for White Sox vs. Giants.
How to watch White Sox vs Giants and game info
| Location | Oracle Park, San Francisco, CA |
| Date | Friday, May 22, 2026 |
| First pitch | 10:15 p.m. ET |
| TV | CHSN, NBC Sports Bay Area |
| White Sox starting pitcher | Davis Martin (6-1, 1.61 ERA) |
| Giants starting pitcher | Trevor McDonald (2-0, 2.37 ERA) |
White Sox vs Giants latest injuries
White Sox vs Giants weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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