Opening Day continues Thursday with a full MLB slate — and with it, our first real chance to attack the betting board.
With teams settling in, pitchers stretching out, and early overreactions already shaping the market, there’s value to be found if you know where to look.
Below, we break down the top moneyline MLB picks for Thursday, March 26.
MLB moneyline picks for March 26
| Matchup | Pick |
|---|---|
 Piratesvs  Mets |
-116 |
 White Soxvs  Brewers |
-192 |
 Nationalsvs  Cubs |
-217 |
 Twinsvs  Orioles |
+109 |
 Angelsvs  Astros |
-175 |
 Tigersvs  Padres |
-137 |
 Raysvs  Cardinals |
-120 |
 Rangersvs  Phillies |
-154 |
 Diamondbacksvs  Dodgers |
-250 |
 Guardiansvs  Mariners |
-250 |
Lines courtesy of Kalshi as of 3-26.
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Expert MLB moneyline picks for March 26
Pirates vs Mets: Pirates (-116)
The New York Mets might be deeper, but early-season volatility + Paul Skenes = value. That’s it. In a game with a low total (6.5), the better pitcher matters more than lineup depth.
White Sox vs Brewers: Brewers (-192)
The Chicago White Sox boast yet another weak roster with limited offensive upside, and the Milwaukee Brewers have the pitching edge with Jacob Misiorowski getting the ball to open up the season.
Nationals vs Cubs: Cubs (-217)
The Chicago Cubs should control this game wire-to-wire. They're the better team with the bigger pitching edge. Laying -240 is not advisable, but it's the right side.
Twins vs Orioles: Twins (+109)
I believe this line is wrong. It's pricing Baltimore as a clear tier above, but I don't believe that's the case. Twins have enough offense to trade blows, and the pitching isn’t a mismatch. You’re getting plus money in what I believe is a coin flip. Take the Twins.
Red Sox vs Reds: 
Reds Sox (-161)
Boston has the more reliable arm and the more complete lineup. Cincinnati can mash when it gets hot, but until then, we will take a wait-and-see approach. This feels like a game Boston controls if Garrett Crochet is dialed in.
Angels vs Astros: Astros (-175)
Houston is just better across the board — lineup, pitching stability, experience. Angels can hang for stretches, but over nine innings, I'll take the better side.
Tigers vs Padres: Tigers (-137)
Tarik Skubal is the separator. When you have the best pitcher in the game, you don’t need to be perfect elsewhere. The Padres are dangerous, but also inconsistent. Detroit has the edge where it matters most early in the season.
Rays vs Cardinals: Rays (-120)
Tampa is almost always undervalued because it doesn’t have star power. Pitching matchup is competitive, and the Rays are better at manufacturing runs. You’re getting plus money on the team that just knows how to get it done.
Rangers vs Phillies: Phillies (-154)
This is one of the tighter games on the board, but Philadelphia at home with the better overall roster is enough. The Texas Rangers are live, but they rely more on timely hitting, and that could be an issue against Cristopher Sanchez.
Diamondbacks vs Dodgers: Dodgers (-250)
Arizona isn’t the team I'd back in a fade of L.A. with, unless you’re getting a much bigger pitching edge. Yoshinobu Yamamoto carries his playoff form into the opener and leads the Dodgers to one of many wins.
Guardians vs Mariners: Mariners (-182)
Seattle is at home with the better starter and more power upside. Cleveland struggled to string hits together last year, and that'll be tough to do today against quality pitching.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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