The San Francisco Giants have dominated the Chicago Cubs in recent memory, but the hosts will grab a victory in today's series opener at Wrigley Field.
My Giants vs Cubs predictions will explain why Chicago, which is a -156 favorite today, is in a prime position to take this contest, with Robbie Ray on the mound for San Francisco.
Read more in my MLB picks for Friday, June 5.
Who will win Giants vs Cubs today: Cubs -1.5 (+120)
The Chicago Cubs will face San Francisco Giants left-hander Robbie Ray this afternoon. He's struggled lately, compiling a 5.85 FIP across his last two starts, and he also owns a 6.24 SIERA during that span.
Ray has completely lost his command (10.13 BB/9), forcing him to serve his offerings on a silver platter over the heart of the plate.
Additionally, 47.6% of his contact over the last 14 days has come through the air, with 10% of those fly balls leaving the yard. That's concerning against a Cubs offense that ranks 12th in home runs, setting him up for a rough day at the office against Chicago's 43.1% hard-hit rate over the last week, while carrying a 107 wRC+ against left-handed pitching.
The real edge is Edward Cabrera's pitch mix returning to Wrigley Field, where he has a 3.89 FIP this season while limiting contact in the air to just 34%.
I'll play this pick to +100.
COVERS INTEL: The Cubs can pull away late against a Giants' bullpen boasting a 5.23 xFIP over the last two weeks. 
Giants vs Cubs Over/Under pick: Under 10.5 runs (+100)
My secondary lean is the Under. While I expect the Cubs to generate offense against Ray, Chicago's pitching staff should be capable of limiting the damage on the other side. With Cabrera returning from the IL, he will likely be on a short leash, and he's failed to pitch more than 4 2/3 innings in either of his last two outings.
That means the Cubs bullpen will play a significant role, and that's hardly a concern. Chicago's relievers own a 3.20 FIP over the last seven days while holding opponents to a .169 ISO and just 0.43 home runs per nine innings.
The Giants haven't shown much power on the road either, carrying a .157 ISO away from home in 2026. If Chicago's bullpen continues its recent form, San Francisco will struggle to generate enough offense to push this game beyond the total.
I'll play this pick to -110.
- ML/RL bets: 21-16, +3.92 units
- Over/Under bets: 22-14, +4.25 units
Giants vs Cubs odds
- Moneyline: Giants +150 | Cubs -156
- Run line: Giants +1.5 (-127) | Cubs -1.5 (+122)
- Over/Under: Over 10.5 (-113) | Under 10.5 (+108)
Giants vs Cubs trend
The San Francisco Giants have hit the Team Total Under in 28 of their last 45 away games (+9.00 Units / 17% ROI). Find more MLB betting trends for Giants vs. Cubs.
How to watch Giants vs Cubs and game info
| Location | Wrigley Field, Chicago, IL |
| Date | Friday, June 5, 2026 |
| First pitch | 2:20 p.m. ET |
| TV | NBCSBA, MARQ |
| Giants starting pitcher | Robbie Ray (3-6, 4.45 ERA) |
| Cubs starting pitcher | Edward Cabrera (3-2, 4.00 ERA) |
Giants vs Cubs latest injuries
Giants vs Cubs weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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