The Houston Astros can’t get home soon enough.
The team has not only struggled on its current 10-game road trip, but this away swing seems cursed. Injuries are piling up for Houston as it plays its final stop against the Seattle Mariners this afternoon.
Houston, which has one win in the first nine games of this trip, is desperate to avoid a sweep in Seattle. It could have bodies back in the infield and provide right-hander Mike Burrows with support on both sides of the plate.
Our Astros vs. Mariners predictions tell Seattle to put away the brooms with my MLB picks hopping on Houston.
Who will win Astros vs Mariners today: Astros moneyline (+156)
The Houston Astros took a 6-1 beating on Sunday but were without SS Jeremy Pena and 3B Carlos Correa.
Correa is expected to return, while Pena is day-to-day. Even just getting Correa back is a boost, providing solid hitting in the middle of the order.
Houston needs to show up for starter Mike Burrows. He’s been serviceable in his last two outings, with five earned runs on 13 hits over 10 1/3 innings.
The Seattle Mariners are hitting well vs. Houston, especially in the later frames, with 14 of 23 runs coming from the fifth inning onward. However, I expect regression from a Mariners lineup that sits near the bottom of most batting stats to start 2026.
COVERS INTEL: Seattle starter George Kirby has allowed a home run in each of his three starts, including two three-run dingers. Houston has one of the hardest-hitting lineups, sitting second in slugging percentage (.454) and third in home runs per outing (1.19).
Astros vs Mariners Over/Under pick: Over 7.5 (+100)
Given the state of the Astros’ injury-plagued bullpen, Houston needs plenty of run support to escape Seattle without a brooming.
The Astros lineup scored 13 runs in the opening two games of the series — both went Over — and Monday’s finale could see Houston hitting hard early and Seattle surging late.
The Astros have been a red-hot Over bet to start 2026, with an 11-5 O/U record. Game models are calling for at least eight runs this afternoon.
Astros vs Mariners odds
- Moneyline: Astros +156 | Mariners -163
- Run line: Astros +1.5 (-138) | Mariners -1.5 (+133)
- Over/Under: Over 7.5 (+100) | Under 7.5 (-104)
Astros vs Mariners trend
The Houston Astros have gone Over the total in 11 of their last 14 games (+7.60 Units/ 9% ROI). Find more MLB betting trends for Astros vs. Mariners.
How to watch Astros vs Mariners and game info
| Location | T-Mobile Field, Seattle, WA |
| Date | Monday, April 13, 2026 |
| First pitch | 4:10 p.m. ET |
| TV | SCHN, Mariners.tv |
| Astros starting pitcher | Mike Burrows (1-2, 5.63 ERA) |
| Mariners starting pitcher | George Kirby (1-2, 3.60 ERA) |
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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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