The 2026 NFL season rolls on into a high-stakes Week 2 slate loaded with powerhouse prime-time battles.
It all kicks off on Thursday Night Football as the Detroit Lions head to Highmark Stadium to clash with the Buffalo Bills in an explosive, interconference opening-night matchup.
The prime-time action picks right back up on Sunday Night Football when the Indianapolis Colts travel to Arrowhead Stadium to challenge the Kansas City Chiefs under the lights.
The week then wraps up with a coast-to-coast showdown on Monday Night Football, featuring the New York Giants visiting SoFi Stadium to take on the Los Angeles Rams.
With Week 2 here, we're tracking the latest NFL odds, spreads, outrights, and totals for every game on the slate.
NFL odds Week 2
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 Detroitvs Buffalo |
+3.5 26% -3.5 74% |
39% 61% |
o50.5 68% u50.5 55% |
 Carolinavs  Atlanta |
+1.5 45% -1.5 55% |
48% 54% |
o44.0 43% u44. 67% |
 Minnesotavs  Chicago |
+2.5 51% -2.5 49% |
41% 60% |
o45.5 24% u45.5 96% |
 Philadelphiavs  Tennessee |
-5.5 67% +5.5 33% |
69% 31% |
o42.5 83% u42.5 97% |
 Pittsburghvs  New England |
+4.5 42% -4.5 58% |
33% 68% |
o43.5 96% u43.5 99% |
 Green Bayvs  New York |
-5.5 66% +5.5 34% |
70% 32% |
o42.5 95% u42.5 38% |
 Clevelandvs  Tampa Bay |
+6.5 24% -6.5 76% |
28% 73% |
o41.5 98% u41.5 56% |
 New Orleansvs  Baltimore |
+7.5 38% -7.5 62% |
23% 78% |
o46.5 97% u46.5 97% |
 Cincinnativs  Houston |
+2.5 30% -2.5 70% |
43% 56% |
o45.5 96% u45.5 56% |
 Jacksonvillevs  Denver |
+2.5 13% -2.5 87% |
41% 59% |
o43.5 70% u43.5 97% |
 Las Vegasvs  Los Angeles |
+8.5 37% -8.5 63% |
23% 79% |
o42.5 56% u42.5 99% |
 Washingtonvs  Dallas |
+4.5 37% -4.5 63% |
34% 67% |
o51.5 49% u51.5 64% |
 Seattlevs  Arizona |
-9.5 21% +9.5 79% |
81% 18% |
o44.5 96% u44.5 99% |
 Miamivs  San Francisco |
+10.5 32% -10. 5 68% |
15% 86% |
o46.5 96% u46.5 67% |
 Indianapolisvs  Kansas City |
+6.5 54% -6.5 46% |
28% 72% |
o47.5 30% u47.5 74% |
 New Yorkvs  Los Angeles |
+8.5 45% -8.5 55% |
19% 82% |
o48.5 20% u48.5 81% |
Lines as of 9-9
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Detroit vs Buffalo odds (Thursday, Sept. 17 at 8:15p.m. ET, Prime Video)
Opening line
- Buffalo -3.5 (Kalshi probability: 74%)
- Under 50.5 (55%)
- View full Detroit vs. Buffalo odds and matchup
- Read our Detroit vs. Buffalo picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Thursday Night Football odds
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Indianapolis vs Kansas City odds (Sunday, Sept. 20 at 8:20p.m. ET, NBC)
Opening line
- Kansas City -6.5 (Kalshi probability: 74%)
- Over 47.5 (74%)
- View full Indianapolis vs. Kansas City odds and matchup
- Read our Indianapolis vs. Kansas City picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Sunday Night Football odds
New York Giants vs Los Angeles odds (Sunday, Sept. 21 at 8:15p.m. ET, ESPN)
Opening line
- Los Angeles -5.5 (Kalshi probability: 74%)
- Under 48.5 (81%)
- View full New York vs. Los Angeles odds and matchup
- Read our New York vs. Los Angeles picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Monday Night Football odds
Covers NFL awards analysis
Best NFL bets this week
Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!
Odds are correct at the time of publishing and are subject to change.
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