My Jaguars vs. Broncos prediction focuses on an impressive Jacksonville offense as they head to Mile High Stadium to take on Denver.
Despite losing their opener, the Broncos enter as 2.5-point home favorites for this Week 2 matchup, set for a 4:05 p.m. ET kickoff on CBS, but the visiting Jags are well-positioned to make noise on the road.
Check out my full spread breakdown and free NFL picks for Sunday below.
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Jaguars vs Broncos prediction: Jaguars +2.5
The standard of opposition wasn’t the best for the Jacksonville Jaguars last time out, but their offense dominated the Browns. The good news is that Trevor Lawrence is continuing to play at the level we saw in his first year under Liam Coen in 2025. He threw four touchdown passes in that win, but this week we’ll see the running back group take more responsibility, something we saw the Chiefs rely on when beating the Denver Broncos on MNF.
That defeat was an ominous warning for new offensive coordinator Davis Webb, and he needs to change things fast. The Broncos' offense ran the fewest plays in Week 1 with 47 and had the second-lowest air yards total at just 92, in addition to the lowest aDOT at 3.3.
COVERS INTEL: The Jaguars are 5-0 ATS in their last five meetings in Denver.
Jaguars vs Broncos combo
I’m so bullish on the Jaguars that in the combo, I want to include them on the moneyline and not just with the points. We saw how Kenneth Walker caused havoc for the Broncos' defense, racking up 173 yards on the ground, and Bhayshul Tuten can be encouraged by that given his tackle-breaking ability. Tuten led the Jags' backfield in the opener, outcarrying Chris Rodriguez 15 to 6 despite only having marginally more snaps, 48% to 41%. He did more with those opportunities, forcing five missed tackles.
Jaylen Waddle’s first game for the Broncos was about as bad as he could have hoped, catching just one of three targets for two yards. However, leading the Broncos with an 82% route participation rate is surely an indicator that he’ll continue to see volume, which should lead to more production.
Jaguars vs Broncos combo
- Jaguars moneyline
- Bhayshul Tuten Over 51.5 rushing yards
- Jaylen Waddle Over 50.5 receiving yards
Jaguars vs Broncos touchdown scorer: Bhayshul Tuten
I’m back at the well with Tuten here. While Rodriguez led the Jags in red-zone carries last week, it really can’t be overstated how much more dangerous Tuten looked with the ball in his hands. We might still see Rodriguez doing goal-line work, but with his speed, agility, and elite tackle-breaking skills, it’s Tuten who is more likely to find the end zone. Don’t forget that this Broncos defense gave up two touchdowns to Kenneth Walker this past Monday.
Jaguars vs Broncos player prop: Parker Washington Over 4.5 receptions
Lawrence has some real weapons at his disposal now, but Parker Washington is arguably the team’s WR1, as he started this season as well as he finished the last. He caught five of six targets for 83 yards in that game and has now recorded five or more catches in five straight games. His 29% target share is an indicator of how essential he is to the offense and is more than double the share of any other pass catcher.
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Jaguars vs Broncos odds
For help understanding probabilities, see our odds calculator.
- Spread: Jaguars +2.5 | Broncos -2.5
- Over/Under: Over 45.5 (51%) | Under 45.5 (50%)
- Moneyline: Jaguars 42% | Broncos 58%
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Jaguars vs Broncos weather
A chance of thunderstorms could be an issue given that Mile High isn’t a dome, while the 8 mph winds are among the highest across Sunday’s slate of games.
Check out our NFL weather page for up-to-date info on every matchup.
Jaguars vs Broncos trend to know
The Jaguars are 9-1 ATS in their past 10 games overall, dating back to last season. Find more NFL betting trends for Jaguars vs. Broncos.
How to watch Jaguars vs Broncos
| Location | Empower Field at Mile High, Denver, Colo. |
| Date | Sunday, Sept. 20, 2026 |
| Kickoff | 4:05 p.m. ET |
| TV | CBS |
Jaguars vs Broncos latest injuries
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