Well, the Kansas City Chiefs are officially out of the playoffs for the first time in over a decade, and Patrick Mahomes has a torn ACL. This has shrunk their Week 16 odds from -11.5 on the look-ahead to just -4.5 against the somehow more hapless Tennessee Titans.
So, that won't exactly be a thrilling marquee matchup.
Instead, the week opens with one of the best contests of the year as the Seattle Seahawks look to enact a bit of revenge over the Los Angeles Rams on Thursday Night Football.
Week 16 also features a pair of Saturday games, with the Philadelphia Eagles (-5.5) at the Washington Commanders, followed by an NFC North showdown between the Green Bay Packers (-2.5) and Chicago Bears, in a game with serious playoff implications.
Let's gear up for the full slate with the early Week 16 odds below.
NFL odds Week 16
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 Rams@  Seahawks |
Seahawks +1.5 | Rams -116 Seahawks -102 |
45.5 |
 Eagles@  Commanders |
Commanders +5.5 | Eagles -290 Commanders +235 |
44.5 |
 Packers@  Bears |
Bears +2.5 | Packers -132 Bears +112 |
46.5 |
 Bills@  Browns |
Browns +10.5 | Bills -670 Browns +490 |
42.5 |
 Chiefs@  Titans |
Titans +4.5 | Chiefs -210 Titans +176 |
37.5 |
 Jets@  Saints |
Saints -4.5 | Jets +176 Saints -210 |
40.5 |
 Vikings@  Giants |
Giants +1.5 | Vikings -130 Giants +110 |
42.5 |
 Chargers@  Cowboys |
Cowboys -2.5 | Chargers +116 Cowboys -136 |
49.5 |
 Buccaneers@  Panthers |
Panthers +2.5 | Buccaneers -142 Panthers +120 |
45.5 |
 Bengals@  Dolphins |
Dolphins -1.5 | Bengals -104 Dolphins -112 |
50.5 |
 Jaguars@  Broncos |
Broncos -3 | Jaguars +132 Broncos -156 |
44.5 |
 Falcons@  Cardinals |
Cardinals +1.5 | Falcons -124 Cardinals +106 |
45.5 |
 Raiders@  Texans |
Texans -14.5 | Raiders +870 Texans -1500 |
37.5 |
 Steelers@  Lions |
Lions -7 | Steelers +290 Lions -360 |
50.5 |
 Patriots@  Ravens |
Ravens -2.5 | Patriots +130 Ravens -154 |
47.5 |
 49ers@  Colts |
Colts +5.5 | 49ers -290 Colts +235 |
46.5 |
Lines as of 12-14
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Rams vs Seahawks odds (Thursday, 8:15 p.m. ET, Prime Video)
Opening line
- Seahawks +1.5
- Over/Under 46.5
- View full Rams vs. Seahawks odds and matchup
- Read our Rams vs. Seahawks picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Thursday Night Football odds
Eagles vs Commanders odds (Saturday, 5:00 p.m. ET, FOX)
Opening line
- Commanders +5.5
- Over/Under 45.5
- View full Eagles vs. Commanders odds and matchup
- Read our Eagles vs. Commanders picks and predictions (coming soon)
Opening line analysis coming soon!
Packers vs Bears odds (Saturday, 8:20 p.m. ET, FOX)
Opening line
- Bears +3.5
- Over/Under 46.5
- View full Packers vs. Bears odds and matchup
- Read our Packers vs. Bears picks and predictions (coming soon)
Opening line analysis coming soon!
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Bills vs Browns odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Browns +8.5
- Over/Under 40.5
- View full Bills vs. Browns odds and matchup
- Read our Bills vs. Browns picks and predictions (coming soon)
Opening line analysis coming soon!
Chiefs vs Titans odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Titans +11.5
- Over/Under 41.5
- View full Chiefs vs. Titans odds and matchup
- Read our Chiefs vs. Titans picks and predictions (coming soon)
Opening line analysis coming soon!
Jets vs Saints odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Saints -3.5
- Over/Under 39.5
- View full Jets vs. Saints odds and matchup
- Read our Jets vs. Saints picks and predictions (coming soon)
Opening line analysis coming soon!
Covers NFL awards analysis
Vikings vs Giants odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Giants +1.5
- Over/Under 41.5
- View full Vikings vs. Giants odds and matchup
- Read our Vikings vs. Giants picks and predictions (coming soon)
Opening line analysis coming soon!
Chargers vs Cowboys odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Cowboys -3
- Over/Under 48.5
- View full Chargers vs. Cowboys odds and matchup
- Read our Chargers vs. Cowboys picks and predictions (coming soon)
Opening line analysis coming soon!
Buccaneers vs Panthers odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Panthers +1.5
- Over/Under 44.5
- View full Buccaneers vs. Panthers odds and matchup
- Read our Buccaneers vs. Panthers picks and predictions (coming soon)
Opening line analysis coming soon!
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Bengals vs Dolphins odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Dolphins +1.5
- Over/Under 49.5
- View full Bengals vs. Dolphins odds and matchup
- Read our Bengals vs. Dolphins picks and predictions (coming soon)
Opening line analysis coming soon!
Jaguars vs Broncos odds (Sunday, 4:05 p.m. ET, FOX)
Opening line
- Broncos -3
- Over/Under 43.5
- View full Jaguars vs. Broncos odds and matchup
- Read our Jaguars vs. Broncos picks and predictions (coming soon)
Opening line analysis coming soon!
Falcons vs Cardinals odds (Sunday, 4:05 p.m. ET, FOX)
Opening line
- Cardinals -1.5
- Over/Under 44.5
- View full Falcons vs. Cardinals odds and matchup
- Read our Falcons vs. Cardinals picks and predictions (coming soon)
Opening line analysis coming soon!
Raiders vs Texans odds (Sunday, 4:25 p.m. ET, CBS)
Opening line
- Texans -12.5
- Over/Under 38.5
- View full Raiders vs. Texans odds and matchup
- Read our Raiders vs. Texans picks and predictions (coming soon)
Opening line analysis coming soon!
Steelers vs Lions odds (Sunday, 4:25 p.m. ET, CBS)
Opening line
- Lions -6.5
- Over/Under 49.5
- View full Steelers vs. Lions odds and matchup
- Read our Steelers vs. Lions picks and predictions (coming soon)
Opening line analysis coming soon!
Patriots vs Ravens odds (Sunday, 8:20 p.m. ET, NBC)
Opening line
- Ravens -2.5
- Over/Under 47.5
- View full Patriots vs. Ravens odds and matchup
- Read our Patriots vs. Ravens picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Sunday Night Football odds
49ers vs Colts odds (Monday, 8:15 p.m. ET, ESPN/ABC)
Opening line
- Colts +6.5
- Over/Under 46.5
- View full 49ers vs. Colts odds and matchup
- Read our 49ers vs. Colts picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Monday Night Football odds
Best NFL bets this week
Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!
Odds are correct at the time of publishing and are subject to change.
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