Opening NFL Week 16 Odds and Betting Lines: Rams -1.5 on TNF

NFL Week 16 odds open with one of the best contests of the year as the Seattle Seahawks look to enact a bit of revenge over the Los Angeles Rams on Thursday Night Football.

Week 16 also features a pair of Saturday games, with the Philadelphia Eagles (-5.5) at the Washington Commanders, followed by an NFC North showdown between the Green Bay Packers (-2.5) and Chicago Bears, in a game with serious playoff implications.

Sunday night sends the New England Patriots to play the Baltimore Ravens and Monday wraps with the San Francisco 49ers facing the Indianapolis Colts and ageless QB Philip Rivers.

Let's gear up for the full slate with the early Week 16 odds below.

NFL odds Week 16

Matchup	Spread	Moneyline	Over/Under
Rams @ Seahawks	Seahawks +1.5	Rams -116 Seahawks -102	44.5
Eagles @ Commanders	Commanders +5.5	Eagles -290 Commanders  +235	44.5
Packers @ Bears	Bears +1.5	Packers -130 Bears +110	46.5
Bills @ Browns	Browns +10.5	Bills -620 Browns +460	42.5
Chiefs @ Titans	Titans +3.5	Chiefs -198 Titans +166	37.5
Jets @ Saints	Saints -4.5	Jets +176 Saints -210	40.5
Vikings @ Giants	Giants +2.5	Vikings -130 Giants +110	43.5
Chargers @ Cowboys	Cowboys -1.5	Chargers -102 Cowboys -116	49.5
Buccaneers @ Panthers	Panthers +2.5	Buccaneers -148 Panthers +126	45.5
Bengals @ Dolphins	Dolphins -1.5	Bengals +102 Dolphins -120	50.5
Jaguars @ Broncos	Broncos -3	Jaguars +138 Broncos -164	45.5
Falcons @ Cardinals	Cardinals +1.5	Falcons -130 Cardinals +110	45.5
Raiders @ Texans	Texans -14.5	Raiders +870 Texans -1500	37.5
Steelers @ Lions	Lions -7	Steelers +280 Lions -350	50.5
Patriots @ Ravens	Ravens -2.5	Patriots +130 Ravens -154	47.5
49ers @ Colts	Colts +5.5	49ers -255 Colts +210	46.5

Lines as of 12-15

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Rams vs Seahawks odds (Thursday, 8:15 p.m. ET, Prime Video)

Opening line

• Seahawks +1.5
• Over/Under 46.5
• View full Rams vs. Seahawks odds and matchup
• Read our Rams vs. Seahawks picks and predictions (coming soon)

Los Angeles opened as a 1.5-point road favorite for this Thursday showdown in the NFC West. The Rams could be without WR Davante Adams, who left Week 15 with a hamstring injury. The Over/Under opened at 46.5 points and quickly slimmed to 44.5 O/U. The extended forecast for Lumen Field is calling for rain and wind gusts up to 20 mph on TNF.

Also see: full Thursday Night Football odds

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Eagles vs Commanders odds (Saturday, 5:00 p.m. ET, FOX)

Opening line

• Commanders +5.5
• Over/Under 44.5
• View full Eagles vs. Commanders odds and matchup
• Read our Eagles vs. Commanders picks and predictions (coming soon)

Philadelphia opened as a 5.5-point road chalk in Washington and some books are up to the key number of six. The Eagles hope to get OT Lane Johnson and DT Jalen Carter back in the trenches for Week 16 but the short week for this Saturday game makes it a smaller window for recovery. This total hit the board at 44.5 points.

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Packers vs Bears odds (Saturday, 8:20 p.m. ET, FOX)

Opening line

• Bears +2.5
• Over/Under 45.5
• View full Packers vs. Bears odds and matchup
• Read our Packers vs. Bears picks and predictions (coming soon)

The Packers are in rough shape for this Saturday game, having lost star pass rusher Micah Parsons to a torn ACL. Additionally, WR1 Christian Watson is questionable after leaving Week 15’s loss at Denver with a rib injury. Green Bay opened as a 2.5-point favorite in Chicago, but those ailments have knocked this spread down to -1.5. The Over/Under opened at 45.5 and jumped to 46.5 points.

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Bills vs Browns odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Browns +10.5
• Over/Under 41.5
• View full Bills vs. Browns odds and matchup
• Read our Bills vs. Browns picks and predictions (coming soon)

After a crazy comeback win at New England, the Bills stay on the road as 10.5-point favorites at Cleveland in Week 16. Some books have dropped this line to Buffalo -10. You’ll want to keep an eye on the status of the Browns’ offensive line, which has multiple starters missing time. This Over/Under opened at 41.5 and has bounced as high as 43.5 before coming back to 42.5.

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Chiefs vs Titans odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Titans +4.5
• Over/Under 38.5
• View full Chiefs vs. Titans odds and matchup
• Read our Chiefs vs. Titans picks and predictions (coming soon)

Patrick Mahomes’ torn ACL was salt in the wound for the Chiefs in Week 15, with Kansas City’s loss to L.A. officially eliminating the defending AFC champs from the playoffs. With backup QB Gardner Minshew under center, the Chiefs opened as 4.5-point favorites at Tennessee and have slimmed to -3.5 overnight (the look-ahead was KC -11.5 before Week 15). The Titans have multiple holes in the secondary, losing three safeties to injury on Sunday. The total hit the board at 38.5 and dropped to 37.5 O/U.

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Jets vs Saints odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Saints -4.5
• Over/Under 39.5
• View full Jets vs. Saints odds and matchup
• Read our Jets vs. Saints picks and predictions (coming soon)

The Saints are marching with back-to-back wins and open as 4.5-point home favorites versus the Jets in Week 16. New Orleans could be down its top two running backs for Week 16, with both Alvin Kamara and Devin Neal dealing with injuries. This total opened at 39.5 and is up to 40.5 points.

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Vikings vs Giants odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Giants +2.5
• Over/Under 44.5
• View full Vikings vs. Giants odds and matchup
• Read our Vikings vs. Giants picks and predictions (coming soon)

The Vikings are riding high off a big road win at Dallas on Sunday night and bring a two-game run to MetLife Stadium. They opened at -2.5, and vig on the Vikes is climbing, indicating a move to a field goal later in the week. This total opened at 44.5 and is down to 43.5 points.

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Chargers vs Cowboys odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Cowboys -1.5
• Over/Under 49.5
• View full Chargers vs. Cowboys odds and matchup
• Read our Chargers vs. Cowboys picks and predictions (coming soon)

The Chargers knocked Kansas City out of playoff contention in a big Week 15 win and now travel to Dallas in Week 16. This spread has bounced around, opening with L.A. as a 1.5-point underdog, then jumping the fence to Bolts -1.5 before coming back to the original line. This Over/Under opened at 49.5.   

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Buccaneers vs Panthers odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Panthers +2.5
• Over/Under 45.5
• View full Buccaneers vs. Panthers odds and matchup
• Read our Buccaneers vs. Panthers picks and predictions (coming soon)

Week 16 presents a huge game in the NFC South, with the Buccaneers visiting the Panthers in a battle atop the division. Tampa Bay has had a mini-bye after losing to Atlanta last Thursday and opened as a 2.5-point road chalk with vig trending toward a move to -3. This total opened at 45.5 points, and we’re seeing juice on the Over hint at a possible rise in the number later in the week. 

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Bengals vs Dolphins odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Dolphins +1.5
• Over/Under 50.5
• View full Bengals vs. Dolphins odds and matchup
• Read our Bengals vs. Dolphins picks and predictions (coming soon)

The Dolphins opened as 1.5-point home underdogs after a rough showing on Monday night. Miami couldn’t get going in the cold at Pittsburgh but comes home to face the Bengals, who were shutout in Week 15. This total opened at 50.5 points.

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Jaguars vs Broncos odds (Sunday, 4:05 p.m. ET, FOX)

Opening line

• Broncos -3
• Over/Under 43.5
• View full Jaguars vs. Broncos odds and matchup
• Read our Jaguars vs. Broncos picks and predictions (coming soon)

This could be a possible AFC postseason preview with the Jaguars and Broncos destined for the tournament. Denver opened as a 2.5-point favorite after beating the Packers in Week 15, and that spread is up to a field goal. This total opened at 43.5 and has quickly risen to 45.5 points with overnight action on the Over. 

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Falcons vs Cardinals odds (Sunday, 4:05 p.m. ET, FOX)

Opening line

• Cardinals -1.5
• Over/Under 45.5
• View full Falcons vs. Cardinals odds and matchup
• Read our Falcons vs. Cardinals picks and predictions (coming soon)

The Falcons are rested off a mini-bye, following their impressive offensive showing last Thursday. Atlanta hit the board as a 1.5-point road underdog, but money on the visitor has pushed this spread over the fence to Falcons -1.5. The Cardinals have ailments all over the offense, with missing pieces in pass protection and RB Bam Knight leaving Week 15’s loss to Houston with an ankle injury. The total opened at 45.5 and climbed to 46.5 O/U. 

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Raiders vs Texans odds (Sunday, 4:25 p.m. ET, CBS)

Opening line

• Texans -14.5
• Over/Under 37.5
• View full Raiders vs. Texans odds and matchup
• Read our Raiders vs. Texans picks and predictions (coming soon)

The Texans are rolling toward a spot in the playoffs and welcome the Raiders to NRG Stadium in Week 16, laying more than a touchdown as 14.5-point faves. Las Vegas could have backup QB Kenny Pickett back under center this Sunday. The Over/Under opened at 37.5 points. 

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Steelers vs Lions odds (Sunday, 4:25 p.m. ET, CBS)

Opening line

• Lions -6.5
• Over/Under 50.5
• View full Steelers vs. Lions odds and matchup
• Read our Steelers vs. Lions picks and predictions (coming soon)

Pittsburgh picked up a big win on Monday and now travel to Detroit as 6.5-point road underdogs. The Over/Under total hit the board at 50.5 and has jumped through the key number of 51 to 51.5 O/U.

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Patriots vs Ravens odds (Sunday, 8:20 p.m. ET, NBC)

Opening line

• Ravens -2.5
• Over/Under 47.5
• View full Patriots vs. Ravens odds and matchup
• Read our Patriots vs. Ravens picks and predictions (coming soon)

The Patriots have to refocus after blowing a 21-0 lead to Buffalo this weekend. They hit the road as 2.5-point underdogs at Baltimore on Sunday Night Football. This Over/Under number hit the board at 47.5 points. 

Also see: full Sunday Night Football odds

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49ers vs Colts odds (Monday, 8:15 p.m. ET, ESPN/ABC)

Opening line

• Colts +5.5
• Over/Under 46.5
• View full 49ers vs. Colts odds and matchup
• Read our 49ers vs. Colts picks and predictions (coming soon)

Philip Rivers made believers out of football fans with his surprisingly serviceable effort in Indianapolis' loss at Seattle. The Colts return home, getting +5.5 against the 49ers on Monday Night Football in Week 16. We’re seeing vig on San Francisco -5.5 shorten, which could indicate a move toward the home side. The total opened at 46.5 points. 

Also see: full Monday Night Football odds

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