49ers 3rd NFC West12-5

Colts 3rd AFC South8-9

8:15PM ET Dec 22, 2025

49ers @ Colts Odds

Game Odds

Game Odds San Francisco 49ers vs. Indianapolis Colts
	Spread	Total	Moneyline
Sports.OddsComparison.BettingLines.Models.BettingSide.SpreadBettingSideVm San Francisco	-4.0 -110	o45.5 -122	-218
Sports.OddsComparison.BettingLines.Models.BettingSide.SpreadBettingSideVm Indianapolis	+4.5 -115	u57.5 -110	+185

Spread

Game Odds San Francisco 49ers vs. Indianapolis Colts
	SF	IND
	-4.0 -110	+4.5 -115

Odds Comparison

ALL BOOKS	SF	IND
DraftKings logo	-4.5 -105	+4.5 -115
bet365 logo	-4.0 -110	+7.5 -120
FanDuel logo	-4.5 -108	+4.5 -118
BetMGM logo	-4.5 -105	+4.5 -115
Caesars logo	-4.5 -105	+4.5 -115

Total

Game Odds vs.
	OVER	UNDER
	o45.5 -122	u57.5 -110

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o45.5 -122	u45.5 -109
bet365 logo	o57.5 -120	u57.5 -110
FanDuel logo	o46.5 -108	u46.5 -118
BetMGM logo	o46.5 -110	u46.5 -110
Caesars logo	o46.5 -110	u46.5 -110

Moneyline

Game Odds San Francisco 49ers vs. Indianapolis Colts
	SF	IND
	-218	+185

Odds Comparison

ALL BOOKS	SF	IND
DraftKings logo	-225	+185
bet365 logo	-225	+185
FanDuel logo	-220	+184
BetMGM logo	-220	+185
Caesars logo	-218	+181

Passing Yards

Brock Purdy Projection 267.11

Game Odds vs.
OVER	UNDER
o243.5 -110	u248.5 -112

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o248.5 -111	u248.5 -113
bet365 logo	o243.5 -110	u243.5 -110
FanDuel logo	o248.5 -112	u248.5 -112
BetMGM logo	o245.5 -115	u245.5 -115
Caesars logo	o247.5 -130	u247.5 -102

Philip Rivers Projection 244.66

Game Odds vs.
OVER	UNDER
o160.5 -135	u168.5 -112

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o165.5 -112	u165.5 -112
bet365 logo	o162.5 -110	u162.5 -110
FanDuel logo	o168.5 -112	u168.5 -112
BetMGM logo	o160.5 -135	u160.5 +100
Caesars logo	o166.5 -122	u166.5 -110

Rushing Yards

Jonathan Taylor Projection 98.45

Game Odds vs.
OVER	UNDER
o100.5 -112	u104.5 -110

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o100.5 -113	u100.5 -111
bet365 logo	o104.5 -110	u104.5 -110
FanDuel logo	o100.5 -112	u100.5 -112
BetMGM logo	o104.5 -115	u103.5 -115
Caesars logo	o100.5 -121	u100.5 -108

Christian McCaffrey Projection 61.46

Game Odds vs.
OVER	UNDER
o61.5 -112	u63.5 -115

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o62.5 -113	u62.5 -111
bet365 logo	o62.5 -120	u62.5 +100
FanDuel logo	o61.5 -112	u61.5 -112
BetMGM logo	o63.5 -115	u63.5 -115
Caesars logo	o62.5 -121	u62.5 -112

Brock Purdy Projection 18.52

Game Odds vs.
OVER	UNDER
o9.5 -135	u12.5 -111

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o12.5 -113	u12.5 -111
bet365 logo	o11.5 -110	u11.5 -110
FanDuel logo	o11.5 -112	u11.5 -112
BetMGM logo	o9.5 -135	u9.5 +105
Caesars logo	o11.5 -137	u11.5 +105

Brian Robinson Jr.

Game Odds vs.
OVER	UNDER
o21.5 -118	u24.5 -108

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o24.5 -116	u24.5 -108
bet365 logo	o22.5 -110	u22.5 -110
FanDuel logo	o24.5 -114	u24.5 -112
BetMGM logo	o21.5 -118	u21.5 -110
Caesars logo	o24.5 -112	u24.5 -118

Game Odds vs.
OVER	UNDER
o0.5 +219	u0.5 -155

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o0.5 +219	u0.5 -283
bet365 logo	o0.5 +205	u0.5 -250
FanDuel logo	o0.5 +200	u0.5 -280
BetMGM logo	o0.5 +115	u0.5 -155
Caesars logo	-	-

Game Odds vs.
OVER	UNDER
o10.5 -105	u10.5 -109

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o10.5 -115	u10.5 -109
bet365 logo	o10.5 -105	u10.5 -115
FanDuel logo	o10.5 -112	u10.5 -112
BetMGM logo	o10.5 -105	u10.5 -125
Caesars logo	o10.5 -117	u10.5 -114

Receiving Yards

Receptions Made

Rushing Attempts

Passing Attempts

Passing Completions

Interceptions Thrown

Rush and Rec Yards

Passing and Rushing Yards

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