The Rams and Chargers wrap up their respective preseasons at SoFi Stadium on Thursday night, with the Chargers sitting as 59% favorites at Kalshi.
Rams coach Sean McVay never plays his starters in preseason, and that won’t change here. The Chargers starters, meanwhile, will see six to nine plays.
My Rams vs. Chargers predictions and NFL picks believe a drive and change with the regulars isn’t going to be enough to tilt things the Chargers' way on August 27, so look the Rams' offense to lead the way to a win and an Over.
Rams vs Chargers prediction
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Who will win Rams vs Chargers: Rams
Prediction markets seem to be putting a great deal of weight on the news about the starters playing for the Chargers.
This will be the first time their entire offensive line has played together this preseason. That probably isn’t enough to change what we’ve seen on the field through the first two exhibition games, however.
The Los Angeles Rams have posted the highest point differential through two games, +42, without a single starter seeing the field this preseason. Only the Bills have scored more than their 54 points on offense, and only the Ravens have allowed fewer than their 12.
The Los Angeles Chargers have been outscored through two preseason games, including a 41-17 beatdown at the hands of the 49ers.
TOP PICK
Rams vs Chargers Over/Under pick: Over 37.5
Neither team has had trouble scoring.
Rams rookie Ty Simpson will likely get the start and go most of the way. The first-round draft pick appears to have lost the backup job to veteran Stetson Bennett, and McVay has hinted that Bennett may not play at all.
That’s no problem for the Rams offense, as Simpson has had the better passer rating in both games so far. He had two touchdowns and 190 yards on 21 of 25 passing in the first game, and was 8 of 12 for 73 in the second.
The Chargers have gotten 476 passing yards and 44 points from the quarterback tandem of DJ Uiagalelei and Trey Lance.
That, coupled with a defense that's allowed 48 points in two games, should help this game reach the Over.
Rams vs Chargers live odds
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How to watch Rams vs Chargers
| Location | SoFi Stadium, Inglewood, CA |
| Date | Thursday, Aug. 27, 2026 |
| Kickoff | 10 p.m. ET |
| TV | KCAL, KCBS |
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