Week 12 is when the NFL schedule really starts to feel like a playoff preview. Contenders are separating, longshots are desperately trying to stay alive, and every line on the board suddenly looks a little sharper.
To see how artificial intelligence stacks up against the market, we fed ChatGPT FanDuel’s latest NFL odds and instructed the large language model to pick straight-up moneyline winners.
The AI bot weighed measurable inputs like recent form, travel and rest, matchup tendencies, and situational performance before determining who will be cashing tickets.
Love it or fade it, the NFL picks are in and the receipts are ready. Let’s ride the algorithm all the way to profit!
Week 12 NFL moneyline picks
| Matchup | Pick |
|---|---|
 Bills vs  Texans |
-290 |
 Vikings vs  Packers |
-310 |
 Colts vs  Chiefs |
-186 |
 Patriots vs  Bengals |
-420 |
 Steelers vs  Bears |
+122 |
 Jets vs  Ravens |
-1150 |
 Giants vs  Lions |
-600 |
 Seahawks vs  Titans |
-1150 |
 Jaguars vs  Cardinals |
-146 |
 Browns vs  Raiders |
-205 |
 Eagles vs  Cowboys |
-174 |
 Falcons vs  Saints |
-126 |
 Buccaneers vs  Rams |
-330 |
 Panthers vs  49ers |
-340 |
Lines courtesy of FanDuel.
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Bills vs Texans: Bills (-290)
Buffalo is a 5.5-point road favorite with a total of 43.5, signaling respect for Josh Allen and a Top 5 Bills offense against Houston’s No. 1 scoring defense.
The Texans have been tough at home, but they’re still just 5-5 and have struggled to generate explosive plays consistently. In a tight, lower-total game, I lean toward the team with the better quarterback and deeper offensive toolbox. I’ll ride the Bills to grind out a road win on the moneyline.
Vikings vs Packers: Packers (-310)
Green Bay sits at 6-3-1 and is a 6.5-point home favorite over the 4-6 Vikings, with a total in the low 40s.
The Packers’ run game with Josh Jacobs and their improved defense make them better equipped for a slower-paced divisional contest at Lambeau. Minnesota’s volatility gives them upset potential, but it also produces stretches of three-and-outs that could bury them on the road.
In a colder-weather late-season game, I’ll lean on the more complete roster and back Green Bay on the moneyline.
Colts vs Chiefs: Chiefs (-186)
This is one of the more intriguing lines of the week: the 5-5 Chiefs are still 3.5-point favorites at home over the 8-2 Colts, with a total around 49.5.
Oddsmakers are telling you Arrowhead plus Patrick Mahomes still matters a lot, even in a down year. Jonathan Taylor and the Colts’ offense can absolutely keep this close, but for straight-up moneyline purposes I don’t want to fade Mahomes in a high-total home spot.
Patriots vs Bengals: Patriots (-420)
New England is laying a full touchdown on the road, with a lofty total of 50.5.
Drake Maye and a 9-2 Patriots squad face a 3-7 Bengals team with one of the league’s worst pass defenses. That combination of elite QB play against a struggling secondary is usually a recipe for chalk to cash on the moneyline. Cincinnati’s path is forcing turnovers and turning this into a track meet; I’m not banking on that. I’ll back the Patriots to handle business.
Steelers vs Bears: Steelers (+122)
Pittsburgh’s path is through defense and coaching. Their front can disrupt the Bears’ run game, force long third downs, and create short fields off sacks and turnovers. If the Steelers avoid giveaways themselves and lean on a conservative, field-position approach plus red-zone efficiency, they can grind out a low-scoring, one-score win on the road.
Jets vs Ravens: Ravens (-1150)
The Jets are 2-8 and just gave up 27 points to New England, while Baltimore is fresh off a win over Cleveland and still very live in the AFC playoff chase. In games with this kind of spread, the upset path is usually turnovers plus special-teams chaos; that’s hard to handicap into existence.
Laying that many points is scary, but for moneyline purposes, I’m comfortable backing the Ravens outright.
Giants vs Lions: Lions (-600)
Detroit is a double-digit favorite at home (around -10.5) with a total just under 50, facing a 2-9 Giants team that’s struggled to keep games competitive.
Jahmyr Gibbs and the Lions’ offense should find plenty of success against a New York defense that’s been on the field too long, too often. Upsets happen, but this is one of the clearer mismatch spots on the Week 12 slate. With Detroit fighting for NFC seeding, I’m happy to keep it simple and back the Lions straight up.
Seahawks vs Titans: Seahawks (-1150)
This is another lopsided line: Seattle is favored by 13.5 on the road with a total of 40.5 against a 1-9 Titans squad.
Jaxon Smith-Njigba and the Seahawks’ passing game have a clear advantage over a Tennessee offense that’s struggled to score and sustain drives. The low total hints at a methodical game script, but Seattle’s talent differential is substantial. Even if you’re wary of laying big points on the spread, the Seahawks are the obvious side for a moneyline parlay anchor.
Jaguars vs Cardinals: Jaguars (-146)
The 6-4 Jaguars have been inconsistent but still possess more offensive firepower than a 3-7 Cardinals team that leans heavily on Trey McBride in the passing game. If the Jags’ pass rush can disrupt Arizona’s timing, their offense should eventually create enough chunk plays to separate.
Road favorites are always a little dicey, but in this spot I’ll trust Jacksonville’s overall talent edge and back the Jags on the moneyline.
Browns vs Raiders: Raiders (-205)
This is a rock fight: Las Vegas is a small favorite (around -3.5) with a total of just 36.5, and both teams enter at 2-8 with Bottom 3 scoring offenses.
When both offenses are this limited, I often side with the home team and the more stable quarterback situation. The Raiders’ defense has also quietly kept them in games. Not exactly a marquee matchup, but for straight-up purposes I’ll ride the Silver and Black to scrape out a low-scoring win.
Eagles vs Cowboys: Eagles (-174)
The Eagles are a 3.5-point road favorite at AT&T Stadium, with a total of 47.5, one of the more competitive lines of the week.
Philly comes in at 8-2, while Dallas sits at 4-5-1 and still searching for high-end consistency on offense. The Eagles’ ability to control the trenches on both sides gives them a reliable baseline; they can win either in a shootout or a grind. That flexibility makes them a strong moneyline play, even in a hostile environment where the Cowboys often play their best.
Falcons vs Saints: Saints (-126)
The spread lists New Orleans as a 1.5-point home favorite in a game with a low total of 39.5.
With both teams under .500 (Falcons 3-7, Saints 2-8), this sets up as a classic NFC South coin flip. In toss-up divisional games, I usually defer to home field and the team less likely to implode on special teams. That nudges me onto the Saints’ side for a tight moneyline play, potentially ideal for round-robin parlays.
Buccaneers vs Rams: Rams (-330)
The Rams are sizable home favorites at SoFi, laying about 6.5 with a total near 49.5 against a 6-4 Bucs squad.
At 8-2, Los Angeles has leaned heavily on Matthew Stafford and Puka Nacua to drive one of the league’s more efficient passing attacks. Tampa Bay can score, but they’re at a disadvantage in both offensive line play and secondary depth here. Over four quarters, that’s a tough combination to overcome. I’ll back the Rams to hold serve in prime time on the moneyline.
Panthers vs 49ers: 49ers (-340)
San Francisco is a 7-point favorite with a total of 48.5, hosting a 6-5 Panthers team led by Bryce Young and Tetairoa McMillan against a 7-4 49ers squad.
Interestingly, the Niners’ pass defense has been vulnerable this year, which gives Carolina a puncher’s chance if they can protect Young. Still, the 49ers’ offensive balance and home-field advantage in a prime-time spot tilt this matchup their way. For straight-up betting, I’m siding with the more complete roster and taking San Francisco on the moneyline.
ChatGPT has gone 112-51 so far this season for +50.82 units.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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