First overall pick Cam Ward gets his first taste of the NFL regular season as he leads the Tennessee Titans into Week 1 against Bo Nix and the Denver Broncos. Kickoff comes your way at 4:05 p.m. ET on FOX.
My Titans vs. Broncos predictions will focus on one of the league’s best defenses containing Ward.
Read more in my NFL picks for Sunday, September 7.
Titans vs Broncos prediction
Titans vs Broncos Best bet: Cam Ward Under 190.5 passing yards (-114)
Tennessee Titans rookie signal-caller Cam Ward has a tall task in the season opener as he heads to The Mile High City to face a Denver Broncos team that surprisingly made the playoffs in 2024. The Miami product has a big arm, and there’s a reason he went first overall. Ward is special, and he will likely have an impressive career.
However, Denver ranked seventh in the NFL last year in fewest total yards allowed. They also allowed only 32 touchdowns, which ranked second-lowest in the league behind only the Los Angeles Chargers. This secondary is elite, and Ward is still going to need time to get his feet under him and find chemistry with his wideouts.
The Broncos also have a phenomenal run defense, which means they will put more pressure on Ward. That will make it more difficult for the rookie to generate any big plays downfield.
Titans vs Broncos same-game parlay
After the Russell Wilson experiment failed, the Broncos desperately needed a QB to come in and make an immediate difference. Bo Nix did just that in ‘24 following an impressive collegiate career. The former Auburn and Oregon standout threw for 3,775 yards last season, including 29 touchdowns against 12 interceptions.
Nix cashed the Over in passing yards in his final three games of the regular season. Although the Titans do have some talent in their secondary, I’ll take Nix to feed off the home crowd and make some noise, which means including his top target, Courtland Sutton.
Sutton led Denver in ‘24 with 81 catches for 1,081 yards and a team-high eight touchdowns as well.
He’s already built impressive chemistry with Nix, and Sutton will be eager to get started on the right foot as he looks to post another 1,000-yard season and hopefully hit double digits in TDs, similar to his 2023 performance.
Titans vs Broncos 3-Leg SGP
- Cam Ward Under 190.5 passing yards (-114)
- Bo Nix Over 210.5 passing yards (-114)
- Courtland Sutton anytime touchdown (Yes: +120)
Our big-ticket SGP: Broncos Beat Titans
The Broncos were 6-2 at home last season and went 12-6 ATS overall. They’ve also covered in 15 of their last 20 games.
Titans vs Broncos 5-Leg SGP
- Cam Ward Under 190.5 passing yards (-114)
- Bo Nix Over 210.5 passing yards (-114)
- Courtland Sutton anytime touchdown (Yes: +120)
- JK Dobbins Over 43.5 rushing yards (-114)
- Denver Broncos -8.5 (-110)
Titans vs Broncos game predictions
Titans vs Broncos moneyline prediction
Denver is a heavy favorite on the moneyline. While -410 offers minimal value, I don’t see them having any issues running away with this one on home soil as the Broncos look to build on last year’s impressive campaign. The Titans aren’t exactly an elite team.
Titans vs Broncos spread prediction
The Broncos are favored by just over a touchdown. I do not see this contest being close. Nix should cook, the RB room will also be productive, and Denver’s defense should be able to contain Ward in his first game.
Titans vs Broncos Over/Under prediction
It wouldn’t surprise me if the Broncos put up points in bunches here, but I still see more value in the Under. While both teams look a lot different now, the last four meetings have cashed the Under.
Titans vs Broncos odds
- Spread: Titans +8.5 (-110) | Broncos -8.5 (-110)
- Moneyline: Titans +350 | Broncos -450
- Over/Under: Over 42.5 (-110) | Under 42.5 (-110)
More NFL picks and odds from Covers
Titans vs Broncos trend to know
The Denver Broncos have covered the Spread in 15 of their last 21 games (+8.45 Units / 37% ROI). Find more NFL betting trends for Titans vs. Broncos.
How to watch Titans vs Broncos
| Location | Mile High Stadium, Denver, CO |
| Date | Sunday, September 7, 2025 |
| Kickoff | 4:05 p.m. ET |
| TV | FOX |
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