The Tennessee Titans open the home portion of their 2025 season against the Los Angeles Rams on Sunday afternoon.
My Rams vs. Titans predictions are looking at Los Angeles running back Kyren Williams to find the end zone.
Read on for the best NFL picks on Sunday, September 14.
Rams vs Titans prediction
Rams vs Titans Best bet: Kyren Williams anytime touchdown (-180)
The Los Angeles Rams stayed true to their name last season, ramming the ball down the throats of their opposition to the tune of 16 touchdowns by running back Kyren Williams.
Williams scored 14 of those on the ground with two more through the air for as many scores as games played last season.
Williams was consistent in finding the end zone as well, scoring a touchdown in 12 of 16 regular-season contests and then one in two postseason games. He kept that up in Week 1 by scoring the Rams’ first touchdown of the game.
The Tennessee Titans allowed a rushing touchdown to J.K. Dobbins last week, which isn’t anything new for them. Tennessee saw running backs score against it in 12 of 17 games last season.
We’re paying a bit of juice here for Williams to score at -180, but that implies a probability of 64.29% when the running back has scored in 14 of his last 19 (73.68%) games.
Rams vs Titans same-game parlay
The Titans allowed a combined 133 yards on 22 carries to running backs RJ Harvey and J.K. Dobbins last week.
While Williams only recorded 66 yards on the ground in the season opener, the Rams should be able to build a lead and let their back do some work in the second half, and cover the spread to boot.
Rams vs Titans SGP
- Kyren Williams anytime touchdown (-180)
- Kyren Williams Over 75.5 rushing yards (-114)
- Los Angeles Rams -5.5 (-115)
Our big-ticket SGP: Adams to the House!
Davante Adams only had four catches in his Rams debut, but he was targeted eight times. Los Angeles should be looking to get its offseason acquisition the ball once again with a chance to score.
Rams vs Titans SGP
- Kyren Williams anytime touchdown (-180)
- Kyren Williams Over 75.5 rushing yards (-114)
- Davante Adams anytime touchdown (+150)
- Davante Adams Over 5.5 receptions (+134)
- Los Angeles Rams -5.5 (-115)
Rams vs Titans odds
- Spread: Rams -5.5 (-105) | Titans +5.5 (-115)
- Moneyline: Rams -235 | Titans +195
- Over/Under: Over 45.5 (-110) | Under 45.5 (-110)
More NFL picks and odds from Covers
Rams vs Titans trend to know
The Los Angeles Rams have covered the Spread in 15 of their last 22 games (+7.35 Units / 30% ROI). Find more NFL betting trends for Rams vs. Titans.
How to watch Rams vs Titans
| Location | Nissan Stadium, Nashville, TN |
| Date | Sunday, September 14, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | CBS |
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