Week 4 of the NFL season is here, and with it comes another full slate of betting opportunities.
From divisional rivalries to another Monday Night Football doubleheader, we’ve broken down every game on the schedule with our best NFL picks against the spread.
Whether you’re looking for sharp edges, potential upsets, or just a little action to sweat on Sunday, here’s how we see each matchup shaking out.
Week 4 NFL picks against the spread
| Matchup | Pick |
|---|---|
 Seahawks vs  Cardinals |
(+1.5) |
 Vikings vs  Steelers |
(+2.5) |
 Titans vs  Texans |
(-7.5) |
 Panthers vs  Patriots |
(-5.5) |
 Chargers vs  Giants |
(-6.5) |
 Saints vs  Bills |
(+16.5) |
 Eagles vs  Buccaneers |
(-3.5) |
 Commanders vs  Falcons |
(+2.5) |
 Browns vs  Lions |
(+8.5) |
 Colts vs  Rams |
(-3.5) |
 Jaguars vs  49ers |
(+3.5) |
 Bears vs  Raiders |
(+1.5) |
 Ravens vs  Chiefs |
(+2.5) |
 Packers vs  Cowboys |
(-6.5) |
 Jets vs  Dolphins |
(+2.5) |
 Bengals vs  Broncos |
(-7) |
Lines courtesy of FanDuel as of 9-23.
Expert Week 4 NFL ATS picks
Seahawks vs. Cardinals: Seahawks (+1.5)
We were on the Cardinals last week vs. the 49ers, and we were lucky to get the cover at +1.5. The Cardinals couldn't muster up anything offensively, and the loss of James Conner will hurt their run game. The Seahawks 'got right' vs. the lowly Saints, and I believe they're the right side in this TNF match.
Vikings vs. Steelers: Steelers (+2.5)
I trusted Jake Browning in his first full start on the road. That was a mistake. I will not do the same for Carson Wentz, even if the game is in Dublin. The Steelers defense will shut the door, and Aaron Rodgers will deliver another solid performance.
Titans vs. Texans: Texans (-7.5)
The Titans have a bad rookie QB in Cam Ward, a head coach who will likely be shown the door this year, and a Bottom 5 defense. If the Texans can't get in the win column here in a big way, then so be it.
Panthers vs. Patriots: Patriots (-5.5)
The Carolina Panthers won 30-0 last week vs. the Atlanta Falcons. If, for a second, you think they are now a good team. Please, do not bet on this game.
Chargers vs. Giants: Chargers (-6.5)
Russell Wilson, Jaxson Dart, hell, even Kirby Smart. It doesn't matter... the Chargers cover this one easily.
Saints vs. Bills: Saints (+16.5)
I've picked the Saints in each of the last two weeks, and we are 1-1 ATS doing so. This is a massive number, and with the Bills hosting SNF against the Patriots next week, the backdoor is wide open.
Eagles vs. Buccaneers: Eagles (-3.5)
Mike Evans will miss some time with an injury. That is an evergreen statement. You know what else is evergreen? The Eagles' ability to win close games and cover spreads.
Commanders vs. Falcons: Falcons (+2.5)
I wholeheartedly believe the Falcons are not as bad as they appeared to be last week. That was a tough spot for them coming off a prime-time win vs. the Vikings. Now, with a week to stew, I say we get their best effort in an upset win vs. the Commanders.
Browns vs. Lions: Browns (+8.5)
The Lions are coming off a back-and-forth win vs. the Baltimore Ravens, and now get to host the lowly Browns. Just like last week, the Cleveland defense can be the difference maker, and at +8.5, that's too many points.
Colts vs. Rams: Rams (-3.5)
I'm still not sold on the Colts being good. They've beaten up on the Dolphins and Titans (barf) and should have lost to the Broncos. I'll take Sean McVay and Matthew Stafford at home.
Covers NFL betting tools
- NFL odds
- NFL picks
- NFL player props
- Super Bowl 60 odds
- Best NFL betting sites
- This week’s NFL matchups
Jaguars vs. 49ers: Jaguars (+3.5)
Trevor Lawrence vs. Mac Jones and/or Brock Purdy. Tough one, but I'll take the hook here on the field goal.
Bears vs. Raiders: Bears (+1.5)
For whatever reason (maybe Mark Davis' haircut), the Raiders are never good enough. For that reason, I will side with the Chicago Bears and an offense that looked like it had a pulse last week.
Ravens vs. Chiefs: Chiefs (+2.5)
I'm picking the Chiefs for two reasons. The Ravens' defense is extremely poor, and the Chiefs don't lose at home.
Packers vs. Cowboys: Packers (-6.5)
The Packers blew a very winnable game last week, but the Cowboys' defense stunk up the joint. Give me Micah Parsons to wreak havoc on the Dallas offensive line, and Jordan Love to drop 35+ on the Cowboys defense.
Jets vs. Dolphins: Jets (+2.5)
There is nothing in this article that says you MUST watch this game. But, if you do, you'll want to take the Jets and the points.
Bengals vs. Broncos: Broncos (-7)
There are many people concerned about the Broncos, but I'm not there yet. Anything short of a 10+ point win vs. a bad Bengals team will be an issue. This team has solid pieces in place; they just need to play a full 60-minute game.
My NFL ATS record is 25-23 this season for -0.3 units.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
