The Jaxson Dart era begins for the New York Giants on Sunday, and he’s being thrown straight into the fire against the in-form Los Angeles Chargers.
L.A. arrives at MetLife Stadium with a 3-0 record, powered by Justin Herbert and a rock-solid defense, but my Chargers vs Giants predictions expect the visitors’ run game to join the party here.
Get the lowdown on this September 28 matchup with my free NFL picks and betting tips.
Chargers vs Giants prediction
Chargers vs Giants Best bet: Omarion Hampton Over 66.5 rushing yards (-114)
All eyes will be on Jaxson Dart this weekend as he tries to breathe life into this New York Giants season, but I’m picking another rookie to steal the headlines in this Week 4 clash.
Omarion Hampton has shown flashes of his upside through the first three games, and Sunday is set up nicely for a breakout performance. Hampton turned 19 carries into 70 yards and a TD against the Denver Broncos last weekend, and his workload is only going to climb after Najee Harris’ season-ending Achilles injury.
The hype around the Giants’ pass rush is valid, but their run defense has been a mess this year. The troubling signs were there in Week 1 as the Washington Commanders shredded New York for 220 yards and two touchdowns on the ground, and even the Kansas City Chiefs’ below-average rushing attack passed the 100-yard mark in New York last Sunday.
That should allow the Los Angeles Chargers to ease the burden on Herbert, who threw 47 passes last time out, and the visitors won’t hesitate to tilt the script towards the run, particularly if they build a lead.
Hampton said it himself, he’s ‘gotta step up’ as the head of the Chargers’ rushing attack. On Sunday, count on him to do just that, adding to the Giants’ misery.
Chargers vs Giants same-game parlay
After the SNF no-show against the Kansas City Chiefs, changes felt inevitable in New York. Still, this is a tough spot to hand Dart his debut, with the L.A. defense ranking in the Top 10 in yards allowed per game against the run and the pass.
The Under is 4-2 in the Giants’ last six outings, and the hosts have hit the 1H Team Total Under in 11 of their past 19 games.
If the Chargers blanket Malik Nabers, I have my doubts about the other New York pass-catchers getting open consistently – and that sets up the Over on Dart rushing yards as a tasty prop. The rookie QB may have no choice but to shift into scramble mode, and he showed off his athleticism in his preseason cameos.
Chargers vs Giants SGP
- Omarion Hampton Over 66.5 rushing yards
- Under 43.5
- Jackson Dart Over 34.5 rushing yards
Our big-ticket SGP: Backfields step to the front
There will surely be some easy throws built into the game plan for Dart this weekend, and Cam Skattebo should be a popular target for the new QB. Skattebo hauled in six catches for 61 yards in Week 3 against the Chiefs, and I like his path to 20+ receiving yards here. Watch for an uptick in snaps too, with backfield mate Tyrone Tracy Jr. ruled out.
Chargers vs Giants SGP
- Omarion Hampton Over 66.5 rushing yards
- Under 43.5
- Jackson Dart Over 34.5 rushing yards
- Cam Skattebo Over 18.5 receiving yards
Chargers vs Giants odds
- Spread: Chargers -6 | Giants +6
- Moneyline: Chargers -279 | Giants +235
- Over/Under: Over 45 | Under 45
More NFL picks and odds from Covers
Chargers vs Giants trend to know
The Giants are 3-7 ATS in their last 10 outings. Find more NFL betting trends for Chargers vs. Giants.
How to watch Chargers vs Giants
| Location | MetLife Stadium, East Rutherford, NJ |
| Date | Sunday, September 21, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | DAZN |
Chargers vs Giants latest injuries
Chargers vs Giants weather
Monitor gametime conditions with our live NFL weather info and learn how weather impacts NFL betting.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
