The Cleveland Browns upset the Green Bay Packers 13-10 last week, but now must go on the road to face the vaunted Detroit Lions at Ford Field.
Of course, the Lions are coming off a big 38-30 win in Baltimore on Monday Night Football.
My Browns vs. Lions predictions expect Detroit to limit Cleveland’s offense on Sunday afternoon.
Read on for my NFL picks for Saturday, September 28.
Browns vs Lions prediction
Browns vs Lions Best bet: Browns Under 16.5 Points (-105)
The Cleveland Browns have scored 16, 17, and 13 points in their three games thus far, and I’m a bit surprised to see this line at 16.5 rather than closer to 13.5.
The Browns were held to Under 16.5 points in 12 of their 17 games last season, and only went Over 16.5 points twice on the road.
While the Detroit Lions allowed Over 16.5 points in 10 of their 17 games last season and have done so in each game this year, the game script for this one should be a slower pace.
Cleveland has the best running defense in the league, limiting the likes of Josh Jacobs and Derrick Henry to 30 and 23 yards, respectively, despite getting 16 and 11 carries. The Browns have allowed a league-low 613 yards overall and just 172 on the ground.
Detroit held the Jaguars, Vikings, and Titans Under 16.5 points at home last season. I see a similar outcome on Sunday afternoon.
Browns vs Lions same-game parlay
If our best bet comes through, the Lions' should easily cover -9.5
Then we have the two Detroit running backs, Jahmyr Gibbs and David Montgomery, to score a touchdown. Each of them scored once in Week 2 and then twice last week in Baltimore.
Browns vs Lions SGP
- Cleveland Browns TT Under 16.5
- Detroit Lions -9.5
- Jahmyr Gibbs anytime touchdown
- David Montgomery anytime touchdown
Our big-ticket SGP: Juking Judkins!
We’re trying to thread the needle here by taking a Browns touchdown and Under 16.5 points, and I’m going with Quinshon Judkins. He leads the Browns with 155 rushing yards on 28 carries and has a touchdown this year.
Browns vs Lions SGP
- Cleveland Browns TT Under 16.5
- Detroit Lions -9.5
- Jahmyr Gibbs anytime touchdown
- David Montgomery anytime touchdown
- Quinshon Judkins anytime touchdown
Browns vs Lions odds
- Spread: Browns +8.5 (-105) | Lions -8.5 (-115)
- Moneyline: Browns +375 | Lions -500
- Over/Under: Over 45.5 (-110) | Under 45.5 (-110)
More NFL picks and odds from Covers
Browns vs Lions trend to know
The Detroit Lions have covered the Spread in 13 of their last 22 games (+4.00 Units / 16% ROI). Find more NFL betting trends for Browns vs. Lions.
How to watch Browns vs Lions
| Location | Ford Field, Detroit, MI |
| Date | Sunday, September 21, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | FOX |
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