The Jacksonville Jaguars host the Carolina Panthers on Sunday afternoon to kick off the 2025 season. Both teams are coming off seasons in which they finished well under .500, but how will things shake out in Week 1?
My Panthers vs. Jaguars predictions are looking at Carolina running back Chuba Hubbard to find the end zone. Read on for the best NFL picks on Sunday, September 7.
Panthers vs Jaguars prediction
Panthers vs Jaguars Best bet: Chuba Hubbard anytime touchdown (-120)
Carolina Panthers running back Chuba Hubbard enjoyed a breakout season in 2024, accumulating 1,195 yards and 10 touchdowns in just 15 games.
He showed signs of that in the previous season with 902 yards and nine scores, and I'm expecting the upward climb to continue as the Panthers have all five of their offensive linemen back for this season.
Hubbard found the end zone in nine of 15 games last season, and the Jacksonville Jaguars were one of the worst teams in the league against the run. The Jags allowed a running back to score in 13 of their 17 games.
Hubbard will be used at the goal line and can break one off, especially against Jacksonville.
Panthers vs Jaguars same-game parlay
While Bryce Young settles into his third season in the NFL, the Panthers should look to lean on Hubbard, especially on the road, where the young quarterback has struggled.
Hubbard had 64+ yards in nine of 15 games last season, including seven games of 90 or more yards if you want to try to run up the ladder.
Even with Hubbard running wild, though, the Jaguars should be able to come out on top at home.
Panthers vs Jaguars 3-leg SGP
- Chuba Hubbard anytime touchdown
- Chuba Hubbard Over 59.5 rushing yards
- Jaguars moneyline
Our big-ticket SGP: Hunting a TD!
Travis Hunter was a unique weapon for Colorado last season, being utilized on both sides of the ball.
The Jaguars are expected to use the Heisman Trophy winner and second overall pick primarily on offense, and they should look to get him involved early in front of their home fans.
Panthers vs Jaguars 5-leg SGP
- Chuba Hubbard anytime touchdown
- Chuba Hubbard Over 59.5 rushing yards
- Jaguars moneyline
- Travis Hunter Over 47.5 receiving yards
- Travis Hunter anytime touchdown
Panthers vs Jaguars game predictions
Panthers vs Jaguars moneyline prediction
We have to lay -200 on the Jaguars, but I’m willing to do that or buy a point to get the spread down to -2.5. This could be a close game, and you don’t want to get hooked to open the season.
Panthers vs Jaguars spread prediction
Carolina struggled on the road last season, and Jacksonville has a more experienced roster across the board. I'll take the Jaguars to cover the -3.5 at home to open the season.
Panthers vs Jaguars Over/Under prediction
Neither offense is strong, both finishing in the Bottom 10 in scoring last season, but the Panthers allowed a league-high 534 points (31.4 per game), with the Jags not too far behind at 25.6 points per game. I’ll fade both offenses with the Under 47.5.
Panthers vs Jaguars odds
- Spread: Panthers +3 | Jaguars -3
- Moneyline: Panthers +125 | Jaguars -150
- Over/Under: Over 46.5 | Under 46.5
More NFL picks and odds from Covers
Panthers vs Jaguars trend to know
The Jaguars have cashed their team total Over in seven of their last nine home games (+4.80 units / 43% ROI). Find more NFL betting trends for Panthers vs. Jaguars.
How to watch Panthers vs Jaguars
| Location | EverBank Stadium, Jacksonville, FL |
| Date | Sunday, September 7, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | FOX |
Panthers vs Jaguars latest injuries
Panthers vs Jaguars weather
Monitor gametime conditions with our live NFL weather info and learn how weather impacts NFL betting.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
