The holiday season has arrived, and the upcoming schedule treats us to three Christmas games... albeit some slightly muddled matchups.
Headlined by the Chicago Bears facing the San Francisco 49ers in a marquee Sunday Night showdown, I’ve got you covered with my favorite NFL picks for the entire Week 17 slate.
Week 17 NFL moneyline picks
| Matchup | Pick |
|---|---|
 Cowboys vs  Commanders |
-330 |
 Lions vs  Vikings |
-290 |
 Broncos vs  Chiefs |
-1100 |
 Texans vs  Chargers |
+110 |
 Ravens vs  Packers |
-136 |
 Cardinals vs  Bengals |
-375 |
 Seahawks vs  Panthers |
-360 |
 Jaguars vs  Colts |
-300 |
 Patriots vs  Jets |
-1100 |
 Steelers vs  Browns |
-190 |
 Saints vs  Titans |
-158 |
 Buccaneers vs  Dolphins |
-245 |
 Giants vs  Raiders |
-120 |
 Eagles vs  Bills |
-136 |
 Bears vs  49ers |
+146 |
 Rams vs  Falcons |
-520 |
Lines courtesy of FanDuel as of 12-23.
Enjoying Covers content? Add us as a preferred source on your Google account
Expert Week 17 NFL moneyline picks
Cowboys vs. Commanders: Cowboys (-330)
First, Jayden Daniels was shut down for the remainder of the season. Now, Marcus Mariota is questionable for Thursday’s divisional showdown with a hand injury.
We’re in 2025, and journeyman quarterback Josh Johnson is set to start a Christmas game. Good luck keeping pace with the Dallas Cowboys’ elite offense in Landover.
Lions vs. Vikings: Lions (-290)
The Detroit Lions' playoff chances are now extremely slim after failing to top Pittsburgh in Week 15, while the Minnesota Vikings will start QB3 Max Brosmer after J.J. McCarthy suffered yet another injury.
The Lions will take this dud of a matchup — one that looked like it would’ve carried high stakes when the schedule first rolled out.
Broncos vs. Chiefs: Broncos (-1100)
You wanted Patrick Mahomes for Christmas... Santa brought Chris Oladokun instead.
The Denver Broncos get back in the win column at Arrowhead.
Texans vs. Chargers: Texans (+110)
The Houston Texans dominated last year’s Wild Card matchup, prevailing 32–12 as 2.5-point underdogs, and I like their No. 1 defense to feast against an undermanned Los Angeles Chargers offensive line.
Houston makes it eight straight wins on Sunday.
Ravens vs. Packers: Packers (-136)
The Baltimore Ravens are allergic to hanging onto double-digit leads under John Harbaugh.
While the Green Bay Packers are fresh off blowing one of their own, Malik Willis showed he can fill in admirably for Jordan Love.
The same can’t be said for Tyler “Snoop" Huntley, as the Ravens offense repeatedly stalled out after Lamar Jackson left SNF with a back injury.
Packers prevail at Lambeau.
Cardinals vs. Bengals: Bengals (-375)
Joe Burrow looked like the Joe Burrow of old against Miami last week.
Going against an even more favorable matchup in Week 16, I expect the Cincinnati Bengals to put up video-game numbers on offense against the Arizona Cardinals.
Meanwhile, Jacoby Brissett will continue his routine of attempting 40+ passes, with his team falling short in the process.
Seahawks vs. Panthers: Seahawks (-360)
Seattle Seahawks fans are on cloud nine after the team’s biggest win of the season, erasing a 30–14 fourth-quarter deficit against the Rams to claim (for now) the No. 1 seed in the NFC.
Although the Carolina Panthers are enjoying a magical season themselves, Seattle boasts the league’s best point differential and holds the upper hand on both sides of the ball.
Jaguars vs. Colts: Jaguars (-300)
So much for making fun of Liam Coen during the offseason.
The quarterback guru has Trevor Lawrence playing the best football of his career over the past month, and the Jacksonville Jaguars will keep it rolling against an Indianapolis Colts team that couldn't force a single punt in its latest loss to the 49ers.
Patriots vs. Jets: Patriots (-1100)
Not only are the New England Patriots fresh off a prime-time win in Baltimore, but they continue to play better on the road, boasting a 7–0 record away from Foxborough.
Drake Maye is coming off his first 300-yard passing performance of the season, and a layup matchup in the Meadowlands will further bolster New England’s bid for the AFC East crown.
Steelers vs. Browns: Steelers (-190)
Aaron Rodgers sports a 106.7 passer rating over his last three starts, and Mike Tomlin has added another winning season to his resume.
Just like their Week 6 battle, the Pittsburgh Steelers are set for another double-digit win over the reeling Cleveland Browns, whose only silver lining is Myles Garrett being just one sack shy of the single-season record.
Covers NFL betting tools
- NFL odds
- NFL picks
- NFL player props
- Super Bowl 60 odds
- Best NFL betting sites
- This week’s NFL matchups
Saints vs. Titans: Saints (-158)
The New Orleans Saints have enjoyed a bit of a second-half surge with Tyler Shough at the helm, winning three straight.
Shough has steadily improved as the season has progressed, while NOLA’s defense has quietly been stingy, ranking Top 5 in third-down percentage and Top 10 in total yards allowed per game.
While Cam Ward is coming off an impressive performance himself, New Orleans’ defense will loom large in Nashville.
Buccaneers vs. Dolphins: Buccaneers (-245)
The Quinn Ewers experiment didn’t go well for the Miami Dolphins last week, with the rookie pivot turning the ball over twice.
Although the Tampa Bay Buccaneers have been dreadful down the stretch, they still control their own destiny in the NFC South.
With one team highly motivated for a dub, I’ll take Baker Mayfield & Co. to prevail, as a loss could prove costly for Todd Bowles’ job security.
Giants vs. Raiders: Raiders (-120)
If you’re a fan of either of these teams, you desperately want to lose in hopes of grabbing the No. 1 overall pick.
That said, the New York Giants remain winless on the road, and the Las Vegas Raiders showed some fight in their latest game against Houston, highlighted by Ashton Jeanty coming off his best game of the season.
I’ll take Vegas to win in the Black Hole.
Eagles vs. Bills: Bills (-136)
Although the Philadelphia Eagles should have their way on the ground, the same can be said for the Buffalo Bills, with James Cook leading the league in rushing yards.
Add in Josh Allen playing at an MVP level, and Buffalo’s 6-1 record at Highmark Stadium should send the Mafia home happy.
Bears vs. 49ers: Bears (+146)
The Chicago Bears have had an extra two days to rest and prepare for this Sunday Night Football showdown in Santa Clara, so I’ll ride with them as short road dogs.
Philip Rivers recently picked apart the San Francisco 49ers defense, and their lack of a pass rush will come back to haunt them against Caleb Williams.
Rams vs. Falcons: Rams (-520)
The Los Angeles Rams completely fell apart in the fourth quarter against Seattle, but Sean McVay will have his team ready to respond against the Atlanta Falcons.
Los Angeles continues to feature the league’s best offense, and it should be rolling from the jump against a Falcons team that has battled inconsistency all season long.
My NFL moneyline record is 151-89 this season for +0.03 units.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
