Depending on the results of the Saturday games, the 11-4 Jacksonville Jaguars could be playing for the division title in Lucas Oil Stadium against the reeling 8-7 Indianapolis Colts on Sunday, December 28
My Jaguars vs. Colts predictions and NFL picks expect Jacksonville to take advantage and score at will against its division rival.
Jaguars vs Colts prediction
Jaguars vs Colts Best bet: Jaguars team total Over 27.5 (-104)
These two met three weeks ago in Florida, with the Jacksonville Jaguars winning 36-19. That was the game in which Daniel Jones, who was already badly hurt, had his season ended. However, it was more the Indianapolis Colts' defense that led to the loss.
The Jaguars scored 28 points in the first half — 14 off two turnovers — and also had two long drives that resulted in touchdowns.
Since their bye week in Week 8, the Jags have averaged 33.0 points per game. That includes scoring 34 on the Broncos, 35 on the Chargers, and 29 on the Texans.
The Jaguars are 12-3 on their team total Over this year, the best record in the NFL in that category. They're especially good on the road, with a 7-0 record on the team total Over. A major reason has been Trevor Lawrence's play.
T-Law has 14 touchdowns and no picks in his last four games, and Jacksonville is 8-for-11 in converting red zone possessions into TDs in their previous two outings.
The Colts have allowed 48 and 36 points in two of their last three games, and the Jags have a ton to play for here.
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Jaguars vs Colts same-game parlay
Jakobi Meyers scored a touchdown in three straight games after getting into the Jags offense, including one against the Colts last time out.
Brenton Strange has at least three catches in four of five games, and Indianapolis has struggled with tight ends recently.
Jaguars vs Colts SGP
- Jaguars team total Over 27.5
- Jakobi Meyers anytime touchdown
- Brenton Strange Over 2.5 catches
Our big-ticket SGP: Taylor turned down
Jacksonville hasn't allowed a single player to reach 75 rushing yards all season, and Jonathan Taylor won't change that.
Jaguars vs Colts SGP
- Jaguars team total Over 27.5
- Jakobi Meyers anytime touchdown
- Brenton Strange Over 2.5 catches
- Jonathan Taylor Under 73.5 rushing yards
Jaguars vs Colts odds
- Spread: Jaguars -5.5 | Colts +5.5
- Moneyline: Jaguars -260 | Colts +215
- Over/Under: Over 48.5 | Under 48.5
More NFL picks and odds from Covers
Jaguars vs Colts trend to know
The Jacksonville Jaguars have hit the team total Over in 15 of their last 20 games. Find more NFL betting trends for Jaguars vs. Colts.
How to watch Jaguars vs Colts
| Location | Lucas Oil Stadium, Indianapolis, IN |
| Date | Sunday, December 28, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | FOX |
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