The NFC South-leading Carolina Panthers host the NFC West-leading Seattle Seahawks, with both teams clinging to one-game divisional leads and looking to clinch.
The Panthers have alternated wins and losses, straight up and ATS, for the last nine weeks. They’re on schedule for a loss this week if the pattern continues. Seattle has won five straight but is just 2-3 ATS over that span.
Seattle has the best record in the conference, while the Panthers hover just over .500. My Seahawks at Panthers predictions and NFL picks look for Seattle to cover as a road favorite.
Kickoff is set for 1:00 p.m. ET from Bank of America Stadium in Charlotte.
Seahawks vs Panthers prediction
Seahawks vs Panthers Best bet: Seahawks -7.5 (-102)
The Carolina Panthers have been winning by the skin of their teeth. After a 30-point victory over Atlanta for their first win, Carolina has earned its next seven wins by a total of 25 points, six of them by a field goal.
As a result, the Panthers have a negative point differential of 50 points. No other team with a point differential that low has more than six wins, and every other playoff contender has a positive differential.
The Seattle Seahawks, on the other hand, have a 12-3 record, and their point differential of +164 leads the NFL. Seattle has topped 30 points in five of its last eight games and three of the last four road games.
The Seahawks also have one of the league’s best defenses. They rank No. 2 in scoring defense, first in Football Outsiders’ DVOA and second in yardage.
Seattle also has an outstanding special teams unit. Kicker Jason Myers leads the league in field goals, and over their winning streak, the Seahawks have had game-breaking kickoff and punt return scores.
The Panthers are getting healthier. Starting tackle Ikem Ekwonu, corner Jaycee Horn and backup players Cam Jackson, Cade Mays and David Moore have missed time recently, but they were all listed as full participation on the most recent injury report.
Seattle played last Thursday night, giving the Seahawks a few extra days to heal up as well, so both teams should be at relatively full strength considering it’s a late-season matchup.
Seattle should be able to keep the train rolling against a team that has had a successful season thanks in large part to luck, clutch play and mirrors.
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Seahawks vs Panthers same-game parlay
The Panthers have gone under in three of their last four, including the last two weeks. They’re weekly script generally calls for a low-scoring grind-it-out game.
Seattle has an offense capable of putting up points, but the Seahawks’ defense prevents totals from getting too high. Prior to last Thursday’s shootout with the Rams, Seattle had given up a total of 25 points in the three previous games.
The Panthers’ run defense is No. 19 in yardage, No. 25 in scoring and No. 23 in average gain. Zach Charbonnet has found the end zone in three of the last four games despite getting 15 or fewer carries every week.
Seahawks vs Panthers SGP
- Seahawks -7.5
- Under 42.5
- Zach Charbonnet anytime touchdown
Our big-ticket SGP: Darnold motivated by facing former team
Bryce Young has had a breakout year, leading a number of late comebacks and setting the team’s single-game passing record. Most games, however, he’s a game manager. He’s been below 193 yards three of the last four weeks.
Tetairoa McMillan has had big plays as a rookie, but he hasn’t been consistent. He’s made only 11 catches on 23 targets over the last four games and has been under 42 yards three of last four weeks.
Sam Darnold is facing his old team, and he’s had 30 or more pass attempts each of the last three weeks.
Seahawks vs Panthers SGP
- Zach Charbonnet anytime touchdown
- Bryce Young Under 193.5 passing yards
- Tetairoa McMillan Under 53.5 receiving yards
- Sam Darnold Over 28.5 passing attempts
Seahawks vs Panthers odds
- Spread: Seattle +1.5 (-120) | Carolina -1.5 (-102)
- Moneyline: Seattle -102 | Carolina -116
- Over/Under: Over 48.5 (-118) | Under 48.5 (-104)
More NFL picks and odds from Covers
Seahawks vs Panthers trend to know
The Seattle Seahawks have hit the Moneyline in 15 of their last 20 games. Find more NFL betting trends for Seahawks vs. Panthers.
How to watch Seahawks vs Panthers
| Location | Bank of America Stadium, Charlotte, NC |
| Date | Sunday, December 28, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | CBS |
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